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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:flucythrinate
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Accession:CHEBI:34763 term browser browse the term
Definition:An organofluorine acaricide that has formula C26H23F2NO4.
Synonyms:exact_synonym: cyano(3-phenoxyphenyl)methyl (2S)-2-[4-(difluoromethoxy)phenyl]-3-methylbutanoate
 related_synonym: (+-)-cyano-(3-phenoxyphenyl)methyl (+)-4-(difluoromethoxy)-alpha-(1-methylethyl)benzeneacetate;   Formula=C26H23F2NO4;   InChI=1S/C26H23F2NO4/c1-17(2)24(18-11-13-21(14-12-18)32-26(27)28)25(30)33-23(16-29)19-7-6-10-22(15-19)31-20-8-4-3-5-9-20/h3-15,17,23-24,26H,1-2H3/t23?,24-/m0/s1;   InChIKey=GBIHOLCMZGAKNG-CGAIIQECSA-N;   SMILES=CC(C)[C@H](C(=O)OC(C#N)c1cccc(Oc2ccccc2)c1)c1ccc(OC(F)F)cc1
 xref: CAS:70124-77-5;   KEGG:C14524
 xref_mesh: MESH:C027975
 xref: PPDB:329


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flucythrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Dihydrotestosterone inhibits the reaction [flucythrinate results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects binding EXP flucythrinate binds to CYP3A4 protein CTD PMID:32278787 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G ESR1 estrogen receptor 1 increases activity EXP flucythrinate results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G MMP9 matrix metallopeptidase 9 affects binding EXP flucythrinate binds to MMP9 protein CTD PMID:32278787 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP
ISO		 flucythrinate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G RORA RAR related orphan receptor A affects binding EXP flucythrinate binds to RORA protein CTD PMID:32278787 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G VDR vitamin D receptor affects binding EXP flucythrinate binds to VDR protein CTD PMID:32278787 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26092
    role 26008
      application 25227
        agrochemical 18134
          flucythrinate 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 26092
    subatomic particle 26067
      composite particle 26067
        hadron 26067
          baryon 26067
            nucleon 26067
              atomic nucleus 26067
                atom 26067
                  main group element atom 25894
                    p-block element atom 25894
                      carbon group element atom 25481
                        carbon atom 25440
                          organic molecular entity 25440
                            heteroorganic entity 24812
                              organochalcogen compound 24421
                                organooxygen compound 24101
                                  carbon oxoacid 22781
                                    carboxylic acid 22761
                                      monocarboxylic acid 21764
                                        fatty acid 19106
                                          short-chain fatty acid 18001
                                            fatty acid 4:0 8289
                                              butyric acid 6790
                                                methylbutyric acid 2455
                                                  isovaleric acid 1683
                                                    2-(4-hydroxyphenyl)-3-methylbutyric acid 8
                                                      flucythrinate 8
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