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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monobenzone
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Accession:CHEBI:34380 term browser browse the term
Definition:The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.
Synonyms:related_synonym: 4-(Benzyloxyl)phenol;   4-(Phenylmethoxy)phenol;   4-Benzyloxy-phenol;   4-Benzyloxyphenol;   Formula=C13H12O2;   Hydroquinone benzyl ether;   Hydroquinone monobenzyl ether;   InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2;   InChIKey=VYQNWZOUAUKGHI-UHFFFAOYSA-N;   MONOBENZYL ETHER OF HYDROQUINONE;   Monobenzyl hydroquinone;   SMILES=OC1=CC=C(OCC2=CC=CC=C2)C=C1;   monobenzona;   monobenzonum;   p-(Benzyloxy)phenol;   p-Hydroxyphenyl benzyl ether
 alt_id: CHEBI:428158
 xref: CAS:103-16-2;   DrugBank:DB00600;   Drug_Central:1834;   KEGG:C14244;   KEGG:D05072;   LINCS:LSM-5642
 xref_mesh: MESH:C006429
 xref: PMID:14843106;   PMID:20498710;   PMID:21326294;   PMID:21566576;   PMID:21689385;   PMID:32785935;   Patent:EP0175701;   Patent:WO8504101;   Reaxys:1958305;   Wikipedia:Monobenzone


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monobenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP monobenzone binds to AFP protein CTD PMID:23013281 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ar androgen receptor affects binding EXP monobenzone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO monobenzone results in increased activity of NR1I2 protein
[monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO monobenzone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO monobenzone affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      chemical role 19460
        antioxidant 16146
          hydroquinone 1003
            monobenzone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic aromatic compound 19371
                                  phenols 18660
                                    benzenediols 9150
                                      benzenediol 1170
                                        hydroquinone 1003
                                          monobenzone 6
paths to the root