CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: adapalene
Accession: CHEBI:31174
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Definition: A naphthoic acid that is CD437 in which the phenolic hydroxy group has been converted to its methyl ether.
Synonyms: exact_synonym: 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid
related_synonym: 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid; Adaferin; Differine; Formula=C28H28O3; InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30); InChIKey=LZCDAPDGXCYOEH-UHFFFAOYSA-N; SMILES=C1C2(CC3CC(CC1C3)C2)C4=C(C=CC(=C4)C5=CC=C6C(=C5)C=CC(=C6)C(=O)O)OC; adapaleno; adapalenum
xref: CAS:106685-40-9; DrugBank:DB00210; Drug_Central:87; KEGG:D01112; LINCS:LSM-37048
xref_mesh: MESH:C063610
xref: PMID:11594670; PMID:12833014; PMID:25016424; PMID:26398439; PMID:26483036; Patent:EP199636; Patent:US4717720; Wikipedia:Adapalene
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Cd1d1
CD1d1 molecule
increases expression
ISO
Adapalene results in increased expression of CD1D protein
CTD
PMID:17518990
NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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Crabp2
cellular retinoic acid binding protein 2
increases expression
ISO
Adapalene results in increased expression of CRABP2 mRNA
CTD
PMID:8396608 PMID:9990415
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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Il10
interleukin 10
decreases expression
ISO
Adapalene results in decreased expression of IL10 protein
CTD
PMID:17518990
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Rarg
retinoic acid receptor, gamma
affects response to substance
ISO
RARG protein affects the susceptibility to Adapalene
CTD
PMID:9990413
NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Adapalene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tlr2
toll-like receptor 2
decreases expression
ISO
Adapalene results in decreased expression of TLR2 protein
CTD
PMID:17518990
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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