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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthoic acid
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Accession:CHEBI:25483 term browser browse the term
Definition:An aromatic carboxylic acid that consists of a naphthalene skeleton substituted by one or more carboxy groups.
Synonyms:exact_synonym: naphthalenecarboxylic acid
 related_synonym: Formula=C11H8O2
 cyclic_relationship: is_conjugate_acid_of CHEBI:25482



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1,4-dihydroxy-2-naphthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:27837168 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
1-hydroxy-2-naphthoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:27837168 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [1-hydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein] CTD PMID:21667204 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein] CTD PMID:21667204 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:21667204 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:21667204 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:21667204 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of NFKBIA protein] CTD PMID:21667204 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:21667204 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:21667204 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 1-hydroxy-2-naphthoic acid analog inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein] CTD PMID:21667204 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
3-Hydroxy-2-naphthoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 3-hydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
adapalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule increases expression ISO Adapalene results in increased expression of CD1D protein CTD PMID:17518990 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Adapalene results in increased expression of CRABP2 mRNA CTD PMID:8396608 PMID:9990415 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Il10 interleukin 10 decreases expression ISO Adapalene results in decreased expression of IL10 protein CTD PMID:17518990 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Rarg retinoic acid receptor, gamma affects response to substance ISO RARG protein affects the susceptibility to Adapalene CTD PMID:9990413 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Adapalene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Adapalene results in decreased expression of TLR2 protein CTD PMID:17518990 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
Oxantel pamoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO oxantel pamoate binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
pamoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions ISO pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO pamoic acid binds to and results in increased activity of GPR35 protein; pamoic acid promotes the reaction [ARRB2 protein binds to GPR35 protein] CTD PMID:20826425 NCBI chr 9:93,526,691...93,539,302
Ensembl chr 9:93,527,127...93,539,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:20826425 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein; Pertussis Toxin inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [pamoic acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:20826425 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
Salmeterol xinafoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO [Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; Salmeterol Xinafoate binds to and results in decreased activity of ADRB1 protein; Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB1 protein] CTD PMID:14730417 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
decreases expression
increases phosphorylation
ISO
EXP
[Salmeterol Xinafoate binds to ADRB2 protein] which results in increased expression of CFTR protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein; Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Salmeterol Xinafoate results in decreased expression of ADRB2 protein
Salmeterol Xinafoate results in increased phosphorylation of ADRB2 protein
[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein
CTD PMID:10516654 PMID:12621035 PMID:14722251 PMID:14730417 PMID:16474418 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Salmeterol Xinafoate binds to and results in decreased activity of ADRB3 protein] which results in decreased abundance of Cyclic AMP; Salmeterol Xinafoate binds to and results in decreased activity of ADRB3 protein; Salmeterol Xinafoate inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Salmeterol Xinafoate results in decreased expression of BCL2 mRNA; Salmeterol Xinafoate results in decreased expression of BCL2 protein CTD PMID:14687023 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP3 protein CTD PMID:15536434 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased activity of CASP8 protein CTD PMID:15536434 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Salmeterol Xinafoate inhibits the reaction [RELA protein binds to CCL11 promoter]; Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]] CTD PMID:15531761 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:15531761 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases expression
ISO [Salmeterol Xinafoate binds to ADRB2 protein] which results in increased expression of CFTR protein; Salmeterol Xinafoate promotes the reaction [CFTR protein binds to SLC9A3R1 protein]
Salmeterol Xinafoate results in increased expression of CFTR protein
CTD PMID:12621035 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Salmeterol Xinafoate inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of CSF2 protein] CTD PMID:9344832 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Salmeterol Xinafoate results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of DUSP1 mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of DUSP1 mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr10:16,680,489...16,683,276 JBrowse link
G H4f16 H4 histone 16 multiple interactions ISO Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased acetylation of H4-16 protein] CTD PMID:15531761
G Il1b interleukin 1 beta multiple interactions ISO [TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate] CTD PMID:20061444 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Salmeterol Xinafoate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:16980553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16980553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in decreased phosphorylation of NFKBIA protein CTD PMID:15536434 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization
ISO [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; Salmeterol Xinafoate affects the localization of and results in increased activity of NR3C1 protein; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]
Salmeterol Xinafoate affects the localization of NR3C1 protein
CTD PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]] CTD PMID:15531761 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Salmeterol Xinafoate results in increased expression of PPARGC1A mRNA CTD PMID:17446185 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Salmeterol Xinafoate inhibits the reaction [RELA protein binds to CCL11 promoter] CTD PMID:15531761 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Salmeterol Xinafoate results in decreased expression of RNASE2 protein CTD PMID:12166584 NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479
JBrowse link
G Rnase3 ribonuclease A family member 3 multiple interactions
decreases expression
ISO [Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]
Salmeterol Xinafoate results in decreased expression of RNASE3 protein
CTD PMID:10573242 PMID:15025036 NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake ISO SLC22A3 protein results in increased uptake of Salmeterol Xinafoate CTD PMID:17920670 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 multiple interactions ISO Salmeterol Xinafoate promotes the reaction [CFTR protein binds to SLC9A3R1 protein] CTD PMID:12621035 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions ISO [Fluticasone co-treated with Salmeterol Xinafoate] results in increased expression of SLPI mRNA; Salmeterol Xinafoate promotes the reaction [Fluticasone results in increased expression of SLPI mRNA] CTD PMID:15860753 PMID:15862954 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased acetylation of H4-16 protein]; Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Salmeterol Xinafoate inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]]; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL11 protein]]; Salmeterol Xinafoate promotes the reaction [15-deoxyprostaglandin J2 inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Salmeterol Xinafoate]
CTD PMID:15531761 PMID:20061444 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          molecule 19572
            cyclic compound 19379
              bicyclic compound 16961
                carbobicyclic compound 5822
                  naphthalenes 3766
                    naphthoic acid 43
                      (3'S,4'R)-3',4',5'-Trihydroxy-8-oxospiro[6,7-dihydronaphthalene-5,2'-oxolane]-2-carboxylic acid 0
                      1,2,3,4-Tetrahydro-4-oxo-1-naphthoic acid 0
                      1,4-dihydroxy-2-naphthoic acid + 4
                      1-hydroxy-2-naphthoic acid 12
                      1-naphthoic acid + 0
                      2,7-dihydroxy-5-methyl-1-naphthoic acid 0
                      2-hydroxy-5-methyl-1-naphthoic acid 0
                      2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid + 0
                      2-naphthalenecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                      2-naphthoic acid + 14
                      3-(2-Carboxyvinyl)naphthalene-2-carboxylic acid 0
                      3-Hydroxy-2-naphthoate + 1
                      3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate 0
                      3-amino-2-naphthoic acid 0
                      3-carboxy-1-[(3-carboxy-2-oxido-1-naphthalenyl)methyl]-2-naphthalenolate 2-[2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)ethyl]-N,N,1-trimethyl-6-quinolin-1-iumamine hydrate 0
                      3-hydroxy-2-naphthalenecarboxylic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester 0
                      3-hydroxy-2-naphthalenecarboxylic acid [2-(4-methyl-1-piperidinyl)-2-oxoethyl] ester 0
                      3-hydroxy-5-methyl-1-naphthoic acid 0
                      3-methoxy-2-naphthalenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] ester 0
                      3-methoxy-4-(2-methoxy-3-methoxycarbonyl-1-naphthalenyl)-2-naphthalenecarboxylic acid methyl ester 0
                      3-methoxy-5-methyl-1-naphthoic acid 0
                      4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid 2-[2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)ethyl]-N,N,1-trimethyl-6-quinolin-1-iumamine 0
                      4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid 3-[2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol 0
                      4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid 2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine 0
                      5-methyl-1-naphthoic acid 0
                      CD437 + 6
                      LSM-3164 0
                      LSM-36456 0
                      LSM-6048 0
                      Lithol Rubine 0
                      Oxantel pamoate 1
                      Propyl isome 0
                      Pyrvinium pamoate 0
                      Salmeterol xinafoate 28
                      adapalene 6
                      dimethyl-(2-phenoxyethyl)-(phenylmethyl)ammonium 3-hydroxy-2-naphthalenecarboxylic acid 0
                      dimethyl-(3-phenoxypropyl)-phenylammonium 3-hydroxy-2-naphthalenecarboxylic acid 0
                      naphthoate ester + 0
                      naphthoyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        aromatic carboxylic acid 11735
                                          naphthoic acid 43
                                            (3'S,4'R)-3',4',5'-Trihydroxy-8-oxospiro[6,7-dihydronaphthalene-5,2'-oxolane]-2-carboxylic acid 0
                                            1,2,3,4-Tetrahydro-4-oxo-1-naphthoic acid 0
                                            1,4-dihydroxy-2-naphthoic acid + 4
                                            1-hydroxy-2-naphthoic acid 12
                                            1-naphthoic acid + 0
                                            2,7-dihydroxy-5-methyl-1-naphthoic acid 0
                                            2-hydroxy-5-methyl-1-naphthoic acid 0
                                            2-hydroxy-7-methoxy-5-methyl-1-naphthoic acid + 0
                                            2-naphthalenecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester 0
                                            2-naphthoic acid + 14
                                            3-(2-Carboxyvinyl)naphthalene-2-carboxylic acid 0
                                            3-Hydroxy-2-naphthoate + 1
                                            3-Hydroxy-7,8-dimethoxy-6-isopropoxy-2-naphthoate 0
                                            3-amino-2-naphthoic acid 0
                                            3-carboxy-1-[(3-carboxy-2-oxido-1-naphthalenyl)methyl]-2-naphthalenolate 2-[2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)ethyl]-N,N,1-trimethyl-6-quinolin-1-iumamine hydrate 0
                                            3-hydroxy-2-naphthalenecarboxylic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester 0
                                            3-hydroxy-2-naphthalenecarboxylic acid [2-(4-methyl-1-piperidinyl)-2-oxoethyl] ester 0
                                            3-hydroxy-5-methyl-1-naphthoic acid 0
                                            3-methoxy-2-naphthalenecarboxylic acid [2-(4-morpholinyl)-2-oxoethyl] ester 0
                                            3-methoxy-4-(2-methoxy-3-methoxycarbonyl-1-naphthalenyl)-2-naphthalenecarboxylic acid methyl ester 0
                                            3-methoxy-5-methyl-1-naphthoic acid 0
                                            4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid 2-[2-(2,5-dimethyl-1-phenyl-3-pyrrolyl)ethyl]-N,N,1-trimethyl-6-quinolin-1-iumamine 0
                                            4-[(3-carboxy-2-hydroxy-1-naphthalenyl)methyl]-3-hydroxy-2-naphthalenecarboxylic acid 3-[2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol 0
                                            4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid 2-[(E)-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine 0
                                            5-methyl-1-naphthoic acid 0
                                            CD437 + 6
                                            LSM-3164 0
                                            LSM-36456 0
                                            LSM-6048 0
                                            Lithol Rubine 0
                                            Oxantel pamoate 1
                                            Propyl isome 0
                                            Pyrvinium pamoate 0
                                            Salmeterol xinafoate 28
                                            adapalene 6
                                            dimethyl-(2-phenoxyethyl)-(phenylmethyl)ammonium 3-hydroxy-2-naphthalenecarboxylic acid 0
                                            dimethyl-(3-phenoxypropyl)-phenylammonium 3-hydroxy-2-naphthalenecarboxylic acid 0
                                            naphthoate ester + 0
                                            naphthoyl group + 0
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