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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-phenylpropionic acid
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Accession:CHEBI:28631 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid substituted at position 3 by a phenyl group.
Synonyms:related_synonym: 3-Phenyl-propionic acid;   3-Phenylpropanoic acid;   3-Phenylpropionsaeure;   3PP;   Formula=C9H10O2;   HYDROCINNAMIC ACID;   Hydrozimtsaeure;   InChI=1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11);   InChIKey=XMIIGOLPHOKFCH-UHFFFAOYSA-N;   Phenylpropanoate;   SMILES=OC(=O)CCc1ccccc1;   benzenepropanoic acid;   benzenepropionic acid;   benzylacetic acid;   beta-phenylpropionic acid;   dihydrocinnamic acid
 alt_id: CHEBI:26002;   CHEBI:26005;   CHEBI:43112;   CHEBI:8103
 xref: Beilstein:907515;   CAS:501-52-0;   DrugBank:DB02024;   ECMDB:ECMDB00764;   Gmelin:102198;   HMDB:HMDB0000764;   KEGG:C05629
 xref_mesh: MESH:C035253
 xref: MetaCyc:3-PHENYLPROPIONATE;   PDBeChem:HCI;   PMID:18062653;   PMID:20972783;   PMID:23470767;   PMID:24216280;   Reaxys:907515;   Wikipedia:Phenylpropanoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:51057


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3-phenylpropionic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO 3-phenylpropionic acid binds to and results in increased activity of HCAR2 protein CTD PMID:31378678 NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO 3-phenylpropionic acid results in decreased expression of PTGS2 protein CTD PMID:16177193 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of 3-phenylpropionic acid
[TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 3-phenylpropionic acid CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 3-phenylpropionic acid CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
3-(3,4-dihydroxyphenyl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO 3,4-dihydroxyphenylpropionic acid binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid
[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
nandrolone phenpropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects localization		 ISO nandrolone phenpropionate binds to and results in increased activity of AR protein
nandrolone phenpropionate affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antifungal agent 16834
            3-phenylpropionic acid 7
              2-aminobenzoylacetic acid 0
              3-(2,5-dimethoxyphenyl)propanoic acid 0
              3-(3,4-dihydroxyphenyl)propanoic acid + 2
              3-(p-nitrophenyl)propanoic acid 0
              3-hydroxy-3-phenylpropionic acid + 0
              3-phenylbutyric acid 0
              3-phenylpropanoyl-CoA 0
              3-phenylpropionate ester + 1
              methyl 3-phenylpropanoate 0
              propyl dihydroferulate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        fatty acid 16792
                                          saturated fatty acid 16519
                                            propionic acid 3800
                                              3-phenylpropionic acid 7
                                                2-aminobenzoylacetic acid 0
                                                3-(2,5-dimethoxyphenyl)propanoic acid 0
                                                3-(3,4-dihydroxyphenyl)propanoic acid + 2
                                                3-(p-nitrophenyl)propanoic acid 0
                                                3-hydroxy-3-phenylpropionic acid + 0
                                                3-phenylbutyric acid 0
                                                3-phenylpropanoyl-CoA 0
                                                3-phenylpropionate ester + 1
                                                methyl 3-phenylpropanoate 0
                                                propyl dihydroferulate 0
paths to the root