Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-(3,4-dihydroxyphenyl)propanoic acid
go back to main search page
Accession:CHEBI:48400 term browser browse the term
Definition:A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity.
Synonyms:related_synonym: 3,4-dihydroxy-beta-phenylpropionic acid;   3,4-dihydroxybenzenepropanoic acid;   3,4-dihydroxybenzenepropionic acid;   3,4-dihydroxydihydrocinnamic acid;   3,4-dihydroxyhydrocinnamic acid;   3,4-dihydroxyphenylpropionic acid;   3-(3,4-dihydroxyphenyl)propionic acid;   Formula=C9H10O4;   InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13);   InChIKey=DZAUWHJDUNRCTF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1ccc(O)c(O)c1;   dihydrocaffeic acid;   hydrocaffeic acid
 alt_id: CHEBI:4556
 xref: Beilstein:2213449;   CAS:1078-61-1;   Gmelin:482169;   HMDB:HMDB0000423;   KEGG:C10447;   KNApSAcK:C00002735
 xref_mesh: MESH:C000995
 xref: PMID:15607645;   PMID:22490054;   PMID:23904092;   Reaxys:2213449
 cyclic_relationship: is_conjugate_acid_of CHEBI:58744


show annotations for term's descendants           Sort by:
3-(3,4-dihydroxyphenyl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO 3,4-dihydroxyphenylpropionic acid binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Tyr tyrosinase increases oxidation
multiple interactions		 ISO TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid
[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione		 CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        antioxidant 16120
          3-(3,4-dihydroxyphenyl)propanoic acid 2
            N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
            dihydrocaffeoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        fatty acid 16689
                                          saturated fatty acid 16375
                                            propionic acid 3806
                                              3-phenylpropionic acid 7
                                                3-(3,4-dihydroxyphenyl)propanoic acid 2
                                                  N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
                                                  dihydrocaffeoyl-CoA 0
paths to the root