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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-(3,4-dihydroxyphenyl)propanoic acid
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Accession:CHEBI:48400 term browser browse the term
Definition:A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity.
Synonyms:related_synonym: 3,4-dihydroxy-beta-phenylpropionic acid;   3,4-dihydroxybenzenepropanoic acid;   3,4-dihydroxybenzenepropionic acid;   3,4-dihydroxydihydrocinnamic acid;   3,4-dihydroxyhydrocinnamic acid;   3,4-dihydroxyphenylpropionic acid;   3-(3,4-dihydroxyphenyl)propionic acid;   Formula=C9H10O4;   InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13);   InChIKey=DZAUWHJDUNRCTF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1ccc(O)c(O)c1;   dihydrocaffeic acid;   hydrocaffeic acid
 alt_id: CHEBI:4556
 xref: Beilstein:2213449;   CAS:1078-61-1;   Gmelin:482169;   HMDB:HMDB0000423;   KEGG:C10447;   KNApSAcK:C00002735
 xref_mesh: MESH:C000995
 xref: PMID:15607645;   PMID:22490054;   PMID:23904092;   Reaxys:2213449
 cyclic_relationship: is_conjugate_acid_of CHEBI:58744


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3-(3,4-dihydroxyphenyl)propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO 3,4-dihydroxyphenylpropionic acid binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
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G Tyr tyrosinase increases oxidation
multiple interactions
ISO TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid
[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione
CTD PMID:20685355 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      chemical role 19345
        antioxidant 14443
          3-(3,4-dihydroxyphenyl)propanoic acid 2
            N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
            dihydrocaffeoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fatty acid 16008
                                            saturated fatty acid 15984
                                              propionic acid 3687
                                                3-phenylpropionic acid 6
                                                  3-(3,4-dihydroxyphenyl)propanoic acid 2
                                                    N(1),N(8)-bis-(dihydrocaffeoyl)spermidine 0
                                                    dihydrocaffeoyl-CoA 0
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