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1,2-dichloroethene - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,2-dichloroethene
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Accession:CHEBI:18882 term browser browse the term
Definition:A chloroethene that has formula C2H2Cl2.
Synonyms:related_synonym: 1,2-Dichloraethen;   1,2-dichloroethylene;   Formula=C2H2Cl2;   InChI=1S/C2H2Cl2/c3-1-2-4/h1-2H;   InChIKey=KFUSEUYYWQURPO-UHFFFAOYSA-N;   SMILES=[H]C(Cl)=C([H])Cl;   acetylene dichloride
 xref: Beilstein:1719345;   CAS:540-59-0;   Gmelin:100732
 xref_mesh: MESH:C035384

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1,2-dichloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression EXP 1,2-dichloroethylene affects the expression of CYP1A1 protein CTD PMID:9493318 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
decreases activity 		EXP 1,2-dichloroethylene affects the expression of CYP1A2 protein
1,2-dichloroethylene results in decreased activity of CYP1A2 protein 		CTD PMID:9493318 PMID:9671540 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression EXP 1,2-dichloroethylene affects the expression of CYP2B1 protein CTD PMID:9493318 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression EXP 1,2-dichloroethylene affects the expression of CYP2B2 protein CTD PMID:9493318 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression
decreases activity 		EXP 1,2-dichloroethylene results in decreased expression of CYP2C11 protein
1,2-dichloroethylene results in decreased activity of CYP2C11 protein 		CTD PMID:9493318 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity EXP 1,2-dichloroethylene results in decreased activity of CYP2C6 protein CTD PMID:9671540 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
decreases expression 		ISO
EXP 		1,2-dichloroethylene inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]
1,2-dichloroethylene results in decreased activity of CYP2E1 protein
1,2-dichloroethylene results in decreased expression of CYP2E1 protein
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride] 		CTD PMID:7871537 PMID:9344893 PMID:9671540 PMID:9851676 PMID:10828257 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
decreases expression 		EXP 1,2-dichloroethylene results in decreased activity of CYP3A2 protein
1,2-dichloroethylene results in decreased expression of CYP3A2 protein 		CTD PMID:9493318 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity
decreases expression 		EXP 1,2-dichloroethylene results in decreased activity of CYP3A23-3A1 protein
1,2-dichloroethylene results in decreased expression of CYP3A23-3A1 protein 		CTD PMID:9493318 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions ISO 1,2-dichloroethylene inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased mutagenesis of PIGA gene]; 1,2-dichloroethylene inhibits the reaction [2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene] CTD PMID:32199159 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
trans-1,2-dichloroethene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 affects expression EXP 1,2-dichloroethylene affects the expression of CYP1A1 protein CTD PMID:9493318 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
decreases activity 		EXP 1,2-dichloroethylene affects the expression of CYP1A2 protein
1,2-dichloroethylene results in decreased activity of CYP1A2 protein 		CTD PMID:9493318 PMID:9671540 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression EXP 1,2-dichloroethylene affects the expression of CYP2B1 protein CTD PMID:9493318 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression EXP 1,2-dichloroethylene affects the expression of CYP2B2 protein CTD PMID:9493318 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression
decreases activity 		EXP 1,2-dichloroethylene results in decreased expression of CYP2C11 protein
1,2-dichloroethylene results in decreased activity of CYP2C11 protein 		CTD PMID:9493318 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity EXP 1,2-dichloroethylene results in decreased activity of CYP2C6 protein CTD PMID:9671540 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
decreases activity 		ISO
EXP 		1,2-dichloroethylene inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene]
1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride]
1,2-dichloroethylene results in decreased expression of CYP2E1 protein
1,2-dichloroethylene results in decreased activity of CYP2E1 protein 		CTD PMID:7871537 PMID:9344893 PMID:9671540 PMID:9851676 PMID:10828257 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
decreases expression 		EXP 1,2-dichloroethylene results in decreased activity of CYP3A2 protein
1,2-dichloroethylene results in decreased expression of CYP3A2 protein 		CTD PMID:9493318 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity
decreases expression 		EXP 1,2-dichloroethylene results in decreased activity of CYP3A23-3A1 protein
1,2-dichloroethylene results in decreased expression of CYP3A23-3A1 protein 		CTD PMID:9493318 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions ISO 1,2-dichloroethylene inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased mutagenesis of PIGA gene]; 1,2-dichloroethylene inhibits the reaction [2,3,3',4,4'-pentachlorobiphenyl results in increased mutagenesis of PIGA gene] CTD PMID:32199159 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      application 20606
        refrigerant 18695
          ethene 7819
            haloethene 7817
              chloroethenes 7817
                1,2-dichloroethene 10
                  cis-1,2-dichloroethene 0
                  trans-1,2-dichloroethene 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            organic hydride 19066
                              organic fundamental parent 19066
                                hydrocarbon 18723
                                  olefin 9059
                                    acyclic olefin 8897
                                      alkene 7976
                                        ethene 7819
                                          haloethene 7817
                                            chloroethenes 7817
                                              1,2-dichloroethene 10
                                                cis-1,2-dichloroethene 0
                                                trans-1,2-dichloroethene 10
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