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MC1568 - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:MC1568
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Accession:CHEBI:140475 term browser browse the term
Definition:A hydroxamic acid that is N-methylpyrrole which is substituted at positions 2 and 5 by 3-(hydroxyamino)-3-oxoprop-1-en-1-yl and 3-(m-fluorophenyl)-3-oxoprop-1-en-1-yl groups, respectively. It is a potent and selective inhibitor of class II (IIa) histone deacetylase (HDAC II).
Synonyms:exact_synonym: 3-{5-[3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl]-1-methyl-1H-pyrrol-2-yl}-N-hydroxyacrylamide
 related_synonym: Formula=C17H15FN2O3;   InChI=1S/C17H15FN2O3/c1-20-14(5-6-15(20)8-10-17(22)19-23)7-9-16(21)12-3-2-4-13(18)11-12/h2-11,23H,1H3,(H,19,22);   InChIKey=QQDIFLSJMFDTCQ-UHFFFAOYSA-N;   MC-1568;   SMILES=N1(C(=CC=C1C(=C(C(C2=CC(=CC=C2)F)=O)[H])[H])C(=C(C(=O)NO)[H])[H])C
 xref: CAS:852475-26-4
 xref_mesh: MESH:C577554
 xref: PMID:15857140;   PMID:23176534;   PMID:24450497;   PMID:27103167;   PMID:27660204;   PMID:27739328;   PMID:28732762;   PMID:29401190;   PMID:29412739;   PMID:29482060;   Reaxys:26700969

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MC1568 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP
ISO 		MC1568 inhibits the reaction [Thimerosal results in increased cleavage of and results in increased activity of CASP3 protein]
MC1568 inhibits the reaction [entinostat results in increased activity of CASP3 protein] 		CTD PMID:25068794 PMID:27660204 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased expression of CD69 protein] CTD PMID:24200994 NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions EXP
ISO 		MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein] CTD PMID:27660204 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Ifng interferon gamma multiple interactions ISO MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased secretion of IFNG protein] CTD PMID:24200994 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased secretion of IL2 protein] CTD PMID:24200994 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO MC1568 inhibits the reaction [enterotoxin B, staphylococcal results in increased secretion of IL6 protein] CTD PMID:24200994 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ngb neuroglobin increases expression
multiple interactions 		ISO MC1568 results in increased expression of NGB mRNA
MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NGB mRNA] 		CTD PMID:25068794 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:106,744,378...106,749,830 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO MC1568 results in increased expression of PTGS2 mRNA
MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PTGS2 mRNA]; MC1568 promotes the reaction [SP3 protein binds to PTGS2 promoter] 		CTD PMID:25068794 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases expression 		ISO MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to NGB promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [SP3 protein binds to PTGS2 promoter]]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]; MC1568 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]; MC1568 promotes the reaction [SP3 protein binds to PTGS2 promoter]
MC1568 results in increased expression of SP3 protein 		CTD PMID:25068794 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO MC1568 promotes the reaction [enterotoxin B, staphylococcal results in increased secretion of TNF protein] CTD PMID:24200994 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    chemical entity 19885
      atom 19885
        nonmetal atom 19809
          carbon atom 19760
            organic molecular entity 19760
              olefinic compound 16967
                enone 9983
                  MC1568 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17545
                                            carboxamide 17545
                                              hydroxamic acid 6342
                                                MC1568 10
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