Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) - Rat Genome Database

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Gene: Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
RGD ID: 620917
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in brush border membrane. Part of phosphatidylinositol 3-kinase complex. Used to study thrombosis. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in glioblastoma; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,6-dinitrotoluene; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: catalytic phosphatidylinositol 3-kinase beta; LOC100910021; p110beta; phosphatidylinositol 3-kinase catalytic subunit beta isoform; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; ptdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,474,017 - 108,579,140 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8108,474,019 - 108,579,331 (-)EnsemblGRCr8
mRatBN7.2899,594,600 - 99,699,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,594,644 - 99,699,663 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8105,261,003 - 105,332,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,460,307 - 103,531,975 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,302,802 - 101,374,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)Ensemblrn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera899,000,434 - 99,072,100 (-)NCBICelera
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-phellandrene  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capecitabine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
Forsythiaside  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
idelalisib  (ISO)
isoflurane  (EXP)
lead(0)  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (ISO)
methidathion  (ISO)
methylmercury(1+)  (ISO)
microcystin-LR  (ISO)
minocycline  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
pyrethrins  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
Sinomenine  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
valproic acid  (ISO)
wortmannin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway  (IEA)
apoptotic cell death pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
Entamoebiasis pathway   (IEA)
epidermal growth factor/neuregulin signaling pathway   (IEA,ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
hepatitis C pathway  (IEA)
influenza A pathway  (IEA)
inositol phosphate metabolic pathway   (IEA)
insulin signaling pathway   (IEA)
Jak-Stat signaling pathway  (IEA)
measles pathway  (IEA)
melanoma pathway   (IEA)
mTOR signaling pathway  (IEA)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
phosphatidylinositol 3-kinase class I signaling pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
small cell lung carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway   (ISO)
type 2 diabetes mellitus pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Alpini G, etal., Gastroenterology 2002 Oct;123(4):1226-37.
2. Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells. An HJ, etal., J Pathol. 2007 Jun;212(2):161-9.
3. PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. Chen H, etal., J Neurooncol. 2011 Aug;104(1):155-67. doi: 10.1007/s11060-010-0492-2. Epub 2010 Dec 29.
4. PI3K-FRAP/mTOR pathway is critical for hepatocyte proliferation whereas MEK/ERK supports both proliferation and survival. Coutant A, etal., Hepatology 2002 Nov;36(5):1079-88.
5. Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes. Crljen V, etal., Biochem J 2002 Aug 1;365(Pt 3):791-9.
6. Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors. Edgar KA, etal., Cancer Res. 2010 Feb 1;70(3):1164-72. doi: 10.1158/0008-5472.CAN-09-2525. Epub 2010 Jan 26.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
10. PI 3-kinase p110beta: a new target for antithrombotic therapy. Jackson SP, etal., Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.
11. Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor. Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25.
12. Endometrial cancer cells exhibit high expression of p110ß and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation. Karlsson T, etal., Oncotarget. 2017 Jan 17;8(3):3881-3894. doi: 10.18632/oncotarget.13989.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Kim YB, etal., Diabetes. 2002 Feb;51(2):443-8.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. Rajala RV, etal., J Biol Chem 2002 Nov 8;277(45):43319-26.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. MicroRNA126 inhibits proliferation and metastasis by targeting pik3r2 in prostate cancer. Song L, etal., Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9.
24. Survival kinase genes present prognostic significance in glioblastoma. Varghese RT, etal., Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7917.
25. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Wang YB, etal., Mol Med Rep. 2018 Nov;18(5):4259-4270. doi: 10.3892/mmr.2018.9453. Epub 2018 Sep 4.
26. PTEN-deficient cancers depend on PIK3CB. Wee S, etal., Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. doi: 10.1073/pnas.0802655105. Epub 2008 Aug 28.
27. PIK3CA and PIK3CB expression and relationship with multidrug resistance in colorectal carcinoma. Wen F, etal., Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
28. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
29. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Yan F, etal., Exp Neurol. 2017 Nov;297:92-100. doi: 10.1016/j.expneurol.2017.07.014. Epub 2017 Jul 27.
30. Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice. Yang B, etal., PLoS One. 2019 Feb 21;14(2):e0201504. doi: 10.1371/journal.pone.0201504. eCollection 2019.
31. Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. Yu WD, etal., World J Gastroenterol. 2014 Nov 21;20(43):16258-67. doi: 10.3748/wjg.v20.i43.16258.
32. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
33. Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Zhu Q, etal., Oncogene. 2008 Jul 31;27(33):4569-79. doi: 10.1038/onc.2008.91. Epub 2008 Mar 31.
Additional References at PubMed
PMID:8889548   PMID:11919689   PMID:14379171   PMID:16625210   PMID:19196950   PMID:19578070   PMID:24631588   PMID:25139353   PMID:25249570   PMID:25327288   PMID:25339672   PMID:35717938  
PMID:36739310   PMID:37338759   PMID:37815888  


Genomics

Comparative Map Data
Pik3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,474,017 - 108,579,140 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8108,474,019 - 108,579,331 (-)EnsemblGRCr8
mRatBN7.2899,594,600 - 99,699,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,594,644 - 99,699,663 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8105,261,003 - 105,332,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,460,307 - 103,531,975 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,302,802 - 101,374,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)Ensemblrn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera899,000,434 - 99,072,100 (-)NCBICelera
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Cytogenetic Map8q31NCBI
PIK3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383138,652,698 - 138,834,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3138,652,336 - 138,834,957 (-)Ensemblhg38GRCh38
GRCh373138,371,540 - 138,553,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,856,921 - 139,960,875 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343139,856,928 - 139,960,883NCBI
Celera3136,799,538 - 136,904,134 (-)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,746,166 - 135,853,444 (-)NCBIHuRef
CHM1_13138,335,402 - 138,442,207 (-)NCBICHM1_1
T2T-CHM13v2.03141,393,413 - 141,575,643 (-)NCBIT2T-CHM13v2.0
Pik3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,920,455 - 99,022,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl998,918,707 - 99,022,674 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38999,038,402 - 99,140,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,036,654 - 99,140,621 (-)Ensemblmm10GRCm38
MGSCv37998,938,821 - 99,040,630 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36998,847,754 - 98,949,439 (-)NCBIMGSCv36mm8
Celera998,576,088 - 98,662,033 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.41NCBI
Pik3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501259,645 - 379,909 (+)Ensembl
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBIChiLan1.0ChiLan1.0
PIK3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22136,561,870 - 136,744,097 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13136,566,598 - 136,748,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,685,120 - 135,867,096 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13143,288,563 - 143,431,314 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3143,288,563 - 143,431,314 (-)EnsemblpanPan2panpan1.1
PIK3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,832,661 - 34,955,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,836,540 - 34,993,939 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2334,826,488 - 35,032,061 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02335,375,472 - 35,581,398 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2335,378,018 - 35,581,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12335,056,048 - 35,262,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02335,121,991 - 35,327,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02335,371,974 - 35,577,846 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pik3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560274,167,334 - 74,302,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540907,112 - 1,041,848 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936540907,118 - 1,041,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,425,835 - 79,610,840 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11379,427,033 - 79,610,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21387,042,709 - 87,067,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,705,585 - 51,885,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1551,775,733 - 51,889,238 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604124,691,992 - 24,889,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473015,226,379 - 15,355,857 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473015,226,786 - 15,399,097 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pik3cb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1890,377,917 - 90,480,574 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pik3cb
390 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000022179
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW523465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ202622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV762942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV765206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022179   ⟹   ENSRNOP00000022179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8108,474,019 - 108,565,110 (-)Ensembl
mRatBN7.2 Ensembl899,594,644 - 99,699,549 (-)Ensembl
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000039271   ⟹   ENSRNOP00000035786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl8106,863,494 - 106,870,994 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112462   ⟹   ENSRNOP00000089360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl899,663,541 - 99,699,663 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000154056   ⟹   ENSRNOP00000111949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8108,474,019 - 108,579,331 (-)Ensembl
RefSeq Acc Id: NM_053481   ⟹   NP_445933
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,017 - 108,545,708 (-)NCBI
mRatBN7.2899,594,642 - 99,666,336 (-)NCBI
Rnor_6.08107,275,881 - 107,347,573 (-)NCBI
Rnor_5.08106,700,158 - 106,788,063 (-)NCBI
RGSC_v3.48103,886,682 - 103,957,112 (-)RGD
Celera899,000,434 - 99,072,100 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595943   ⟹   XP_017451432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,140 (-)NCBI
mRatBN7.2899,594,600 - 99,699,772 (-)NCBI
Rnor_6.08107,275,849 - 107,381,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595946   ⟹   XP_017451435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,138 (-)NCBI
mRatBN7.2899,594,600 - 99,699,770 (-)NCBI
Rnor_6.08107,275,849 - 107,381,088 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595947   ⟹   XP_017451436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,578,750 (-)NCBI
mRatBN7.2899,594,600 - 99,699,387 (-)NCBI
Rnor_6.08107,275,849 - 107,380,798 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005487938
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,579,140 (-)NCBI
mRatBN7.2899,594,600 - 99,699,772 (-)NCBI
RefSeq Acc Id: XR_010054039
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,474,025 - 108,578,750 (-)NCBI
RefSeq Acc Id: NP_445933   ⟸   NM_053481
- UniProtKB: Q9Z1L0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017451432   ⟸   XM_017595943
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451435   ⟸   XM_017595946
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451436   ⟸   XM_017595947
- Peptide Label: isoform X1
- UniProtKB: G3V839 (UniProtKB/TrEMBL),   A6I2C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022179   ⟸   ENSRNOT00000022179
Ensembl Acc Id: ENSRNOP00000035786   ⟸   ENSRNOT00000039271
Ensembl Acc Id: ENSRNOP00000089360   ⟸   ENSRNOT00000112462
Ensembl Acc Id: ENSRNOP00000111949   ⟸   ENSRNOT00000154056
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0T1-F1-model_v2 AlphaFold F1M0T1 1-237 view protein structure
AF-Q9Z1L0-F1-model_v2 AlphaFold Q9Z1L0 1-1070 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696208
Promoter ID:EPDNEW_R6732
Type:multiple initiation site
Name:Pik3cb_1
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunitbeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08107,380,849 - 107,380,909EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620917 AgrOrtholog
BioCyc Gene G2FUF-29405 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000016384 Ensembl, ENTREZGENE
  ENSRNOG00000023622 Ensembl
Ensembl Transcript ENSRNOT00000022179 ENTREZGENE
  ENSRNOT00000154056 ENTREZGENE
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.10.20.770 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot
  PI3Kbeta_dom UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:85243 UniProtKB/Swiss-Prot
NCBI Gene 85243 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PhenoGen Pik3cb PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_ABD UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_RBD UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016384 RatGTEx
  ENSRNOG00000023622 RatGTEx
SMART PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_p85B UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
  PI3Kc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0ABK0M7S3_RAT UniProtKB/TrEMBL
  A6I2C5 ENTREZGENE, UniProtKB/TrEMBL
  G3V839 ENTREZGENE, UniProtKB/TrEMBL
  PK3CB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  LOC100910021  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like  Data merged from RGD:6500836 737654 PROVISIONAL
2012-10-10 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  Pik3cb  phosphoinositide-3-kinase, catalytic, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910021  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Pik3cb  phosphoinositide-3-kinase, catalytic, beta polypeptide  Pik3cb  phosphatidylinositol 3-kinase, catalytic, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Pik3cb  phosphatidylinositol 3-kinase, catalytic, beta polypeptide    phosphatidylinositol 3-kinase, catalytic subunit, beta isoform  Name updated 1299863 APPROVED
2002-08-07 Pik3cb  phosphatidylinositol 3-kinase, catalytic subunit, beta isoform      Symbol and Name status set to provisional 70820 PROVISIONAL