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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620917
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Acc ID: CHEBI:65329
Term: LY294002
Definition: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Chemical ID: MESH:C085911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cbdecreases activityISOPik3cb (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CB proteinPMID:16179367
Pik3cbdecreases expressionISOPIK3CB (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of PIK3CB proteinPMID:35122754
Pik3cbincreases expressionISOPik3cb (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PIK3CB mRNAPMID:31522336
Pik3cbmultiple interactionsISOPIK3CB (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of PIK3CB protein]PMID:35122754
Pik3cbmultiple interactionsISOPik3cb (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]PMID:31522336
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