Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) - Rat Genome Database

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Gene: Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) Chinchilla lanigera
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Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
RGD ID: 8961332
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (ortholog); insulin receptor substrate binding (ortholog); INVOLVED IN angiogenesis involved in wound healing (ortholog); embryonic cleavage (ortholog); endothelial cell proliferation (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); diffuse large B-cell lymphoma (ortholog); endometrial cancer (ortholog); FOUND IN brush border membrane (ortholog); intracellular membrane-bounded organelle (ortholog); midbody (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501259,645 - 379,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pik3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501259,645 - 379,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBIChiLan1.0ChiLan1.0
PIK3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383138,652,698 - 138,834,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3138,652,698 - 138,834,928 (-)EnsemblGRCh38hg38GRCh38
GRCh373138,371,540 - 138,553,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,856,921 - 139,960,875 (-)NCBINCBI36Build 36hg18NCBI36
Build 343139,856,928 - 139,960,883NCBI
Celera3136,799,538 - 136,904,134 (-)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,746,166 - 135,853,444 (-)NCBIHuRef
CHM1_13138,335,402 - 138,442,207 (-)NCBICHM1_1
T2T-CHM13v2.03141,393,413 - 141,575,643 (-)NCBIT2T-CHM13v2.0
Pik3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,920,455 - 99,022,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl998,918,707 - 99,022,674 (-)EnsemblGRCm39 Ensembl
GRCm38999,038,402 - 99,140,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,036,654 - 99,140,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv37998,938,821 - 99,040,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36998,847,754 - 98,949,439 (-)NCBIMGSCv36mm8
Celera998,576,088 - 98,662,033 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.41NCBI
Pik3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,474,017 - 108,579,140 (-)NCBIGRCr8
mRatBN7.2899,594,600 - 99,699,772 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,594,644 - 99,699,663 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8105,261,003 - 105,332,672 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,460,307 - 103,531,975 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,302,802 - 101,374,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Celera899,000,434 - 99,072,100 (-)NCBICelera
Cytogenetic Map8q31NCBI
PIK3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22136,561,870 - 136,744,097 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13136,566,598 - 136,748,779 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,685,120 - 135,867,096 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13143,288,563 - 143,431,314 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3143,288,563 - 143,431,314 (-)Ensemblpanpan1.1panPan2
PIK3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,832,661 - 34,955,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,836,540 - 34,993,939 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2334,826,488 - 35,032,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02335,375,472 - 35,581,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2335,378,018 - 35,581,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12335,056,048 - 35,262,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02335,121,991 - 35,327,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02335,371,974 - 35,577,846 (-)NCBIUU_Cfam_GSD_1.0
Pik3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560274,167,334 - 74,302,042 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540907,112 - 1,041,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936540907,118 - 1,041,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,425,835 - 79,610,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11379,427,033 - 79,610,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21387,042,709 - 87,067,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,705,585 - 51,885,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1551,775,733 - 51,889,238 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604124,691,992 - 24,889,924 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473015,226,379 - 15,355,857 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473015,226,786 - 15,399,097 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000005497   ⟹   ENSCLAP00000005401
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955501259,645 - 284,998 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000005498   ⟹   ENSCLAP00000005402
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955501282,672 - 379,909 (+)Ensembl
RefSeq Acc Id: XM_013505790   ⟹   XP_013361244
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013361244 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005401.1
  ENSCLAP00000005402
  ENSCLAP00000005402.1
RefSeq Acc Id: XP_013361244   ⟸   XM_013505790
- UniProtKB: A0A8C2UTR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000005401   ⟸   ENSCLAT00000005497
RefSeq Acc Id: ENSCLAP00000005402   ⟸   ENSCLAT00000005498

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003835 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005497.1 UniProtKB/TrEMBL
  ENSCLAT00000005498 ENTREZGENE
  ENSCLAT00000005498.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.10.20.770 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K-type_C2_dom UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Pik3cb ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM UniProtKB/TrEMBL
  PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
PROSITE C2_PI3K UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UTR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UZF9_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta  Symbol and/or name change 5135510 APPROVED