Raf1 (Raf-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Raf1 (Raf-1 proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
RGD ID: 3531
Description: Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-RAF; cRaf; Murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); proto-oncogene c-RAF; RAF proto-oncogene serine/threonine-protein kinase; raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-leukemia viral oncogene 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,352,158 - 150,412,813 (-)NCBIGRCr8
mRatBN7.24148,679,534 - 148,740,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,679,530 - 148,740,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,903,973 - 154,964,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,687,056 - 150,747,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,310,879 - 149,371,650 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,532,040 - 147,592,769 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,819,148 - 210,878,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,752,583 - 151,775,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,997,425 - 152,020,450 (-)NCBI
Celera4137,570,499 - 137,631,125 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chaetoglobosin A  (EXP)
choline  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cruentaren A  (ISO)
curcumin  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dabrafenib  (ISO)
decabromodiphenyl ether  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
Dephostatin  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
Dictamnine  (ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
eckol  (ISO)
emodin  (EXP,ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ferrostatin-1  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
Goe 6976  (EXP)
GW 1929  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (ISO)
indole-3-methanol  (EXP)
lapatinib  (ISO)
lead diacetate  (ISO)
letrozole  (ISO)
lipopolysaccharide  (EXP)
lipoteichoic acid  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
maneb  (ISO)
mangiferin  (ISO)
manumycin A  (EXP)
melatonin  (ISO)
metformin  (ISO)
Methanandamide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
morphine  (EXP,ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimodipine  (ISO)
nitric oxide  (EXP)
okadaic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
Parthenin  (ISO)
PD173074  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perillyl alcohol  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
PhIP  (ISO)
phloretin  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
quinomethionate  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
Salvianolic acid A  (ISO)
semilicoisoflavone B  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
SR 144528  (ISO)
streptozocin  (EXP)
styrene  (ISO)
SU6656  (ISO)
tanespimycin  (ISO)
Tautomycin  (ISO)
testosterone  (EXP,ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
cell differentiation  (ISO)
chromatin remodeling  (IEA)
death-inducing signaling complex assembly  (IEA,ISO)
ERBB2-ERBB3 signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
face development  (IEA,ISO)
heart development  (IEP)
insulin receptor signaling pathway  (IEA,ISO)
insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intermediate filament cytoskeleton organization  (IEA,ISO)
intracellular glucose homeostasis  (ISO)
intracellular signal transduction  (TAS)
MAPK cascade  (IBA,IDA,IEA,IMP)
myelination  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of protein-containing complex assembly  (IEA,ISO)
neurotrophin TRK receptor signaling pathway  (IEA,ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein phosphorylation  (IDA,IMP,TAS)
response to hypoxia  (IDA)
response to muscle stretch  (IEA,ISO)
Schwann cell development  (IEA,ISO)
signal transduction  (IEA)
somatic stem cell population maintenance  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
type B pancreatic cell proliferation  (IEA,ISO)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (IBA,IEA,ISO,TAS)
Golgi apparatus  (IEA,ISO)
mitochondrion  (IBA)
nucleus  (IEA)
plasma membrane  (IDA,IEA,ISO)
pseudopodium  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (IEA,ISO)
Fc gamma receptor mediated signaling pathway  (IEA)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway  (IEA,ISO)
insulin-like growth factor signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (ISO)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
platelet-derived growth factor signaling pathway   (ISO)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IMP,ISO,TAS)
tuberculosis pathway  (IEA)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of Raf in vascular protection from distinct apoptotic stimuli. Alavi A, etal., Science 2003 Jul 4;301(5629):94-6.
2. Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity. Chan EY, etal., Mol Carcinog 2002 Apr;33(4):189-97.
3. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. DeFea KA, etal., J Cell Biol. 2000 Mar 20;148(6):1267-81.
4. Endothelial ERK signaling controls lymphatic fate specification. Deng Y, etal., J Clin Invest. 2013 Mar;123(3):1202-15. doi: 10.1172/JCI63034. Epub 2013 Feb 8.
5. Raf kinase activation of adenylyl cyclases: isoform-selective regulation. Ding Q, etal., Mol Pharmacol. 2004 Oct;66(4):921-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK. Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
9. Gene Data File Integration of LocusLink data, October 12, 2001
10. Rat c-raf oncogene activation by a rearrangement that produces a fused protein. Ishikawa F, etal., Mol Cell Biol 1987 Mar;7(3):1226-32.
11. Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy. Kanwar M and Kowluru RA, Microvasc Res. 2008 Nov;76(3):189-93. Epub 2008 Apr 25.
12. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
13. Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. Kobayashi T, etal., Hum Mutat. 2010 Mar;31(3):284-94. doi: 10.1002/humu.21187.
14. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
15. Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas. McFarlin DR, etal., Carcinogenesis 2003 Jan;24(1):99-105.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Raf-1 expression may influence progression to androgen insensitive prostate cancer. Mukherjee R, etal., Prostate. 2005 Jun 15;64(1):101-7. doi: 10.1002/pros.20211.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Pal A, etal., Int J Oncol. 2005 Apr;26(4):1087-91.
21. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Pandit B, etal., Nat Genet. 2007 Aug;39(8):1007-12. Epub 2007 Jul 1.
22. Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine. Pei J, etal., Anticancer Drugs. 2004 Mar;15(3):243-53.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Razzaque MA, etal., Nat Genet. 2007 Aug;39(8):1013-7. Epub 2007 Jul 1.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
31. Regulation and role of Raf-1/B-Raf heterodimerization. Rushworth LK, etal., Mol Cell Biol. 2006 Mar;26(6):2262-72.
32. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
33. Hypoxia and hypoxia/reoxygenation activate Raf-1, mitogen-activated protein kinase kinase, mitogen-activated protein kinases, and S6 kinase in cultured rat cardiac myocytes. Seko Y, etal., Circ Res. 1996 Jan;78(1):82-90.
34. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Shu FJ, etal., Cell Signal. 2010 Mar;22(3):366-76. doi: 10.1016/j.cellsig.2009.10.005. Epub .
35. Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats. Silverman JA, etal., Mol Carcinog. 1990;3(6):379-86.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. Trakul N, etal., J Biol Chem. 2005 Jul 1;280(26):24931-40. Epub 2005 May 10.
39. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, etal., PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25.
40. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
41. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
42. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. Wu X, etal., J Clin Invest. 2011 Mar;121(3):1009-25. doi: 10.1172/JCI44929. Epub 2011 Feb 21.
43. Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Wu X, etal., Mol Cell Biol. 2012 Oct;32(19):3872-90. doi: 10.1128/MCB.00751-12. Epub 2012 Jul 23.
44. Insulin enhances growth hormone induction of the MEK/ERK signaling pathway. Xu J, etal., J Biol Chem. 2006 Jan 13;281(2):982-92. Epub 2005 Nov 4.
45. Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning. Xuan YT, etal., Circulation. 2005 Sep 27;112(13):1971-8. Epub 2005 Sep 19.
Additional References at PubMed
PMID:8026469   PMID:8307946   PMID:9551081   PMID:9560161   PMID:9679960   PMID:9765203   PMID:9852579   PMID:9931261   PMID:10329666   PMID:10407019   PMID:10644344   PMID:10704835  
PMID:11698596   PMID:12194967   PMID:12551925   PMID:12821670   PMID:12954639   PMID:14654844   PMID:14978028   PMID:15211515   PMID:15489334   PMID:15975997   PMID:16009725   PMID:16365167  
PMID:16396499   PMID:16737746   PMID:16954213   PMID:17554210   PMID:17724343   PMID:17979178   PMID:18243549   PMID:18328477   PMID:18708364   PMID:18952847   PMID:19381846   PMID:19667065  
PMID:20110729   PMID:20130576   PMID:20442316   PMID:20718739   PMID:20953701   PMID:21440552   PMID:21817126   PMID:21917714   PMID:22169110   PMID:22510884   PMID:22610096   PMID:22983684  
PMID:23022482   PMID:23509299   PMID:23611784   PMID:23928917   PMID:24885948   PMID:25367879   PMID:28057484   PMID:30140388   PMID:31521821   PMID:33424842   PMID:34229010  


Genomics

Comparative Map Data
Raf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,352,158 - 150,412,813 (-)NCBIGRCr8
mRatBN7.24148,679,534 - 148,740,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,679,530 - 148,740,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,903,973 - 154,964,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,687,056 - 150,747,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,310,879 - 149,371,650 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,532,040 - 147,592,769 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,819,148 - 210,878,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,752,583 - 151,775,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,997,425 - 152,020,450 (-)NCBI
Celera4137,570,499 - 137,631,125 (-)NCBICelera
Cytogenetic Map4q42NCBI
RAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,583,601 - 12,664,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,582,101 - 12,664,201 (-)EnsemblGRCh38hg38GRCh38
GRCh37312,625,100 - 12,705,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,600,108 - 12,680,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34312,600,107 - 12,680,678NCBI
Celera312,563,426 - 12,643,994 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,559,317 - 12,640,382 (-)NCBIHuRef
CHM1_1312,575,179 - 12,655,743 (-)NCBICHM1_1
T2T-CHM13v2.0312,582,405 - 12,665,632 (-)NCBIT2T-CHM13v2.0
Raf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,595,530 - 115,653,596 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,595,028 - 115,653,596 (-)EnsemblGRCm39 Ensembl
GRCm386115,618,569 - 115,676,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,618,067 - 115,676,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,568,591 - 115,626,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,584,216 - 115,642,122 (-)NCBIMGSCv36mm8
Celera6117,458,696 - 117,516,733 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.62NCBI
Raf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,025,932 - 18,049,723 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,980,956 - 18,049,723 (+)NCBIChiLan1.0ChiLan1.0
RAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,570,434 - 12,649,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,575,188 - 12,654,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,510,084 - 12,590,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,853,415 - 12,932,871 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,853,415 - 12,932,871 (-)Ensemblpanpan1.1panPan2
RAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,892,839 - 5,972,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl205,921,827 - 6,000,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBIUU_Cfam_GSD_1.0
Raf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,795,336 - 17,819,736 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,051,205 - 1,117,096 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,089,979 - 1,114,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,580,812 - 68,657,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,581,128 - 68,657,911 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,848,344 - 75,927,158 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,560,270 - 48,643,537 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,561,161 - 48,618,020 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041117,857,289 - 117,941,171 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Raf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624872204,357 - 269,135 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624872204,357 - 284,487 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Raf1
172 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:83
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000013831
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4148423102157580971Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
RH127364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,679,257 - 148,679,472 (+)MAPPERmRatBN7.2
Rnor_6.04147,531,764 - 147,531,978NCBIRnor6.0
Rnor_5.04210,818,872 - 210,819,086UniSTSRnor5.0
RGSC_v3.44151,752,307 - 151,752,521UniSTSRGSC3.4
Celera4137,570,223 - 137,570,437UniSTS
RH 3.4 Map15457.3UniSTS
Cytogenetic Map4q42UniSTS
RH142970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,683,589 - 148,683,722 (+)MAPPERmRatBN7.2
Rnor_6.04147,536,095 - 147,536,227NCBIRnor6.0
Rnor_5.04210,823,203 - 210,823,335UniSTSRnor5.0
RGSC_v3.44151,756,638 - 151,756,770UniSTSRGSC3.4
Celera4137,574,554 - 137,574,686UniSTS
RH 3.4 Map4952.1UniSTS
Cytogenetic Map4q42UniSTS
BI284862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,679,723 - 148,679,931 (+)MAPPERmRatBN7.2
Rnor_6.04147,532,230 - 147,532,437NCBIRnor6.0
Rnor_5.04210,819,338 - 210,819,545UniSTSRnor5.0
RGSC_v3.44151,752,773 - 151,752,980UniSTSRGSC3.4
Celera4137,570,689 - 137,570,896UniSTS
RH 3.4 Map4950.71UniSTS
Cytogenetic Map4q42UniSTS
RH139128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,683,086 - 148,683,210 (+)MAPPERmRatBN7.2
Rnor_6.04147,535,592 - 147,535,715NCBIRnor6.0
Rnor_5.04210,822,700 - 210,822,823UniSTSRnor5.0
RGSC_v3.44151,756,135 - 151,756,258UniSTSRGSC3.4
Celera4137,574,051 - 137,574,174UniSTS
RH 3.4 Map4951.41UniSTS
Cytogenetic Map4q42UniSTS
UniSTS:469819  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,679,655 - 148,680,192 (+)MAPPERmRatBN7.2
Rnor_6.04147,532,162 - 147,532,698NCBIRnor6.0
Rnor_5.04210,819,270 - 210,819,806UniSTSRnor5.0
RGSC_v3.44151,752,705 - 151,753,241UniSTSRGSC3.4
Celera4137,570,621 - 137,571,157UniSTS
Cytogenetic Map4q42UniSTS
Raf1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,694,134 - 148,694,684 (+)MAPPERmRatBN7.2
Rnor_6.04147,546,640 - 147,547,189NCBIRnor6.0
Rnor_5.04210,833,748 - 210,834,297UniSTSRnor5.0
RGSC_v3.44151,767,183 - 151,767,732UniSTSRGSC3.4
Celera4137,585,099 - 137,585,648UniSTS
Cytogenetic Map4q42UniSTS
Raf1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,680,275 - 148,680,866 (+)MAPPERmRatBN7.2
Rnor_6.04147,532,782 - 147,533,371NCBIRnor6.0
Rnor_5.04210,819,890 - 210,820,479UniSTSRnor5.0
Celera4137,571,241 - 137,571,830UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013831   ⟹   ENSRNOP00000013831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,679,530 - 148,740,210 (-)Ensembl
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105918   ⟹   ENSRNOP00000082418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,679,534 - 148,740,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109662   ⟹   ENSRNOP00000092271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,679,534 - 148,740,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119226   ⟹   ENSRNOP00000094673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,679,534 - 148,740,317 (-)Ensembl
RefSeq Acc Id: NM_012639   ⟹   NP_036771
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,158 - 150,412,813 (-)NCBI
mRatBN7.24148,679,534 - 148,740,195 (-)NCBI
Rnor_6.04147,532,040 - 147,592,699 (-)NCBI
Rnor_5.04210,819,148 - 210,878,226 (-)NCBI
RGSC_v3.44151,752,583 - 151,775,609 (-)RGD
Celera4137,570,499 - 137,631,125 (-)RGD
Sequence:
RefSeq Acc Id: XM_008763217   ⟹   XP_008761439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,412,675 (-)NCBI
mRatBN7.24148,679,541 - 148,740,265 (-)NCBI
Rnor_6.04147,532,047 - 147,592,769 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763218   ⟹   XP_008761440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,412,182 (-)NCBI
mRatBN7.24148,679,635 - 148,739,511 (-)NCBI
Rnor_6.04147,532,047 - 147,592,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107056   ⟹   XP_038962984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,412,299 (-)NCBI
mRatBN7.24148,679,635 - 148,739,684 (-)NCBI
RefSeq Acc Id: XM_039107057   ⟹   XP_038962985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,412,133 (-)NCBI
mRatBN7.24148,679,635 - 148,739,574 (-)NCBI
RefSeq Acc Id: XM_063285558   ⟹   XP_063141628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,412,299 (-)NCBI
RefSeq Acc Id: XM_063285559   ⟹   XP_063141629
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,375,542 (-)NCBI
RefSeq Acc Id: XM_063285560   ⟹   XP_063141630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84150,352,165 - 150,375,542 (-)NCBI
RefSeq Acc Id: NP_036771   ⟸   NM_012639
- UniProtKB: P11345 (UniProtKB/Swiss-Prot),   A6IKZ0 (UniProtKB/TrEMBL),   A0A8L2Q6F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761439   ⟸   XM_008763217
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWZ7 (UniProtKB/TrEMBL),   A0A8L2Q6F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761440   ⟸   XM_008763218
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWZ7 (UniProtKB/TrEMBL),   A0A8L2Q6F4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013831   ⟸   ENSRNOT00000013831
RefSeq Acc Id: XP_038962984   ⟸   XM_039107056
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZWZ7 (UniProtKB/TrEMBL),   A0A8L2Q6F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962985   ⟸   XM_039107057
- Peptide Label: isoform X2
- UniProtKB: P11345 (UniProtKB/Swiss-Prot),   A6IKZ0 (UniProtKB/TrEMBL),   A0A8L2Q6F4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094673   ⟸   ENSRNOT00000119226
Ensembl Acc Id: ENSRNOP00000082418   ⟸   ENSRNOT00000105918
Ensembl Acc Id: ENSRNOP00000092271   ⟸   ENSRNOT00000109662
RefSeq Acc Id: XP_063141628   ⟸   XM_063285558
- Peptide Label: isoform X2
- UniProtKB: P11345 (UniProtKB/Swiss-Prot),   A6IKZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141630   ⟸   XM_063285560
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141629   ⟸   XM_063285559
- Peptide Label: isoform X3
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11345-F1-model_v2 AlphaFold P11345 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693324
Promoter ID:EPDNEW_R3849
Type:initiation region
Name:Raf1_1
Description:Raf-1 proto-oncogene, serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,592,708 - 147,592,768EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3531 AgrOrtholog
BioCyc Gene G2FUF-43318 BioCyc
Ensembl Genes ENSRNOG00000010153 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009196 UniProtKB/Swiss-Prot
  ENSRNOG00060026872 UniProtKB/Swiss-Prot
  ENSRNOG00065031890 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013831.7 UniProtKB/TrEMBL
  ENSRNOT00000105918.1 UniProtKB/TrEMBL
  ENSRNOT00000109662.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119226.1 UniProtKB/TrEMBL
  ENSRNOT00055015599 UniProtKB/Swiss-Prot
  ENSRNOT00060046681 UniProtKB/Swiss-Prot
  ENSRNOT00065054973 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599540 IMAGE-MGC_LOAD
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_protein_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72519 IMAGE-MGC_LOAD
NCBI Gene 24703 ENTREZGENE
PANTHER RAF PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RAF1 RGD
PhenoGen Raf1 PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010153 RatGTEx
  ENSRNOG00055009196 RatGTEx
  ENSRNOG00060026872 RatGTEx
  ENSRNOG00065031890 RatGTEx
SMART RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216965
UniProt A0A8I5ZWZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALJ3_RAT UniProtKB/TrEMBL
  A0A8L2Q6F4 ENTREZGENE, UniProtKB/TrEMBL
  A6IKZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6IKZ2_RAT UniProtKB/TrEMBL
  P11345 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Raf1  Raf-1 proto-oncogene, serine/threonine kinase  Raf1  v-raf-leukemia viral oncogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Raf1  v-raf-leukemia viral oncogene 1  Raf1  v-raf-1 murine leukemia viral oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Raf1  v-raf-1 murine leukemia viral oncogene homolog 1    murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)  Name updated 1299863 APPROVED
2002-06-10 Raf1  v-raf-1 murine leukemia viral oncogene homolog 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates Map2k1 and Mek2 70317
gene_function phosphorylates Map2k1 and Mek2 70441
gene_process may activate Mapk1 and Mapk3 in fetal heart development 70317
gene_process may activate Mapk1 and Mapk3 in fetal heart development 70441