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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1affects expressionISORaf1 (Mus musculus)6480464CTDAcetaminophen affects the expression of RAF1 mRNAPMID:17562736
Raf1decreases expressionISORAF1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of RAF1 mRNAPMID:25704631
Raf1increases phosphorylationISORaf1 (Mus musculus)6480464CTDAcetaminophen results in increased phosphorylation of RAF1 proteinPMID:27720869
Raf1increases phosphorylationISORAF1 (Homo sapiens)6480464CTDAcetaminophen results in increased phosphorylation of RAF1 proteinPMID:27720869
Raf1multiple interactionsISORaf1 (Mus musculus)6480464CTDcaffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]PMID:27720869
Raf1multiple interactionsISORAF1 (Homo sapiens)6480464CTDcaffeic acid inhibits the reaction [Acetaminophen results in increased phosphorylation of RAF1 protein]PMID:27720869
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