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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1multiple interactionsEXP 6480464CTD[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of RAF1 mRNAPMID:22129741
Raf1multiple interactionsISORaf1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [NSC 680410 results in decreased expression of RAF1 protein]PMID:16481037
Raf1multiple interactionsISORAF1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [tubocapsenolide A results in increased degradation of RAF1 protein]PMID:18442981
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