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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]PMID:18708364
Raf1decreases expressionISORAF1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of RAF1 proteinPMID:18089832
Raf1multiple interactionsISORaf1 (Mus musculus)6480464CTDresveratrol inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]PMID:24333336
Raf1multiple interactionsISORAF1 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl promotes the reaction [[AHR protein binds to ARNT protein] which binds to RAF1 promoter]]; resveratrol inhibits the reaction [Paclitaxel results in increased phosphorylation of RAF1 protein]PMID:12510025 PMID:18708364
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