Raf1 (Raf-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Raf1 (Raf-1 proto-oncogene, serine/threonine kinase) Chinchilla lanigera
Analyze
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
RGD ID: 8850973
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); ATP binding (ortholog); INVOLVED IN cell differentiation (ortholog); death-inducing signaling complex assembly (ortholog); ERBB2-ERBB3 signaling pathway (ortholog); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Cardiomegaly (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: RAF proto-oncogene serine/threonine-protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,025,932 - 18,049,723 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,980,956 - 18,049,723 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Raf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,025,932 - 18,049,723 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,980,956 - 18,049,723 (+)NCBIChiLan1.0ChiLan1.0
RAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,583,601 - 12,664,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,582,101 - 12,664,201 (-)EnsemblGRCh38hg38GRCh38
GRCh37312,625,100 - 12,705,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,600,108 - 12,680,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34312,600,107 - 12,680,678NCBI
Celera312,563,426 - 12,643,994 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,559,317 - 12,640,382 (-)NCBIHuRef
CHM1_1312,575,179 - 12,655,743 (-)NCBICHM1_1
T2T-CHM13v2.0312,582,405 - 12,665,632 (-)NCBIT2T-CHM13v2.0
Raf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,595,530 - 115,653,596 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,595,028 - 115,653,596 (-)EnsemblGRCm39 Ensembl
GRCm386115,618,569 - 115,676,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,618,067 - 115,676,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,568,591 - 115,626,653 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,584,216 - 115,642,122 (-)NCBIMGSCv36mm8
Celera6117,458,696 - 117,516,733 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.62NCBI
Raf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84150,352,158 - 150,412,813 (-)NCBIGRCr8
mRatBN7.24148,679,534 - 148,740,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,679,530 - 148,740,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,903,973 - 154,964,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,687,056 - 150,747,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04149,310,879 - 149,371,650 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,532,040 - 147,592,769 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,819,148 - 210,878,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,752,583 - 151,775,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,997,425 - 152,020,450 (-)NCBI
Celera4137,570,499 - 137,631,125 (-)NCBICelera
Cytogenetic Map4q42NCBI
RAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,570,434 - 12,649,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,575,188 - 12,654,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,510,084 - 12,590,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,853,415 - 12,932,871 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,853,415 - 12,932,871 (-)Ensemblpanpan1.1panPan2
RAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,892,839 - 5,972,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl205,921,827 - 6,000,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBIUU_Cfam_GSD_1.0
Raf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,795,336 - 17,819,736 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,051,205 - 1,117,096 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,089,979 - 1,114,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,580,812 - 68,657,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,581,128 - 68,657,911 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,848,344 - 75,927,158 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,560,270 - 48,643,537 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,561,161 - 48,618,020 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041117,857,289 - 117,941,171 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Raf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624872204,357 - 269,135 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624872204,357 - 284,487 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000015120   ⟹   ENSCLAP00000014961
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542918,025,932 - 18,049,723 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000015121   ⟹   ENSCLAP00000014962
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542918,028,467 - 18,049,009 (+)Ensembl
RefSeq Acc Id: XM_005387107   ⟹   XP_005387164
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542918,025,931 - 18,049,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387108   ⟹   XP_005387165
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542917,980,956 - 18,049,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005387109   ⟹   XP_005387166
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542918,025,932 - 18,049,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013515404   ⟹   XP_013370858
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542918,003,505 - 18,049,723 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013515405   ⟹   XP_013370859
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542918,007,347 - 18,049,723 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005387165   ⟸   XM_005387108
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387164   ⟸   XM_005387107
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005387166   ⟸   XM_005387109
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VL96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370858   ⟸   XM_013515404
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370859   ⟸   XM_013515405
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VFT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000014961   ⟸   ENSCLAT00000015120
RefSeq Acc Id: ENSCLAP00000014962   ⟸   ENSCLAT00000015121
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010316 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015120 ENTREZGENE
  ENSCLAT00000015120.1 UniProtKB/TrEMBL
  ENSCLAT00000015121 ENTREZGENE
  ENSCLAT00000015121.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Raf1 ENTREZGENE
PANTHER RAF PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A8C2VFT9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VL96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Raf1  Raf-1 proto-oncogene, serine/threonine kinase    v-raf-1 murine leukemia viral oncogene homolog 1  Symbol and/or name change 5135510 APPROVED