Arrb2 (arrestin, beta 2) - Rat Genome Database

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Gene: Arrb2 (arrestin, beta 2) Rattus norvegicus
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Symbol: Arrb2
Name: arrestin, beta 2
RGD ID: 2157
Description: Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including positive regulation of transport; regulation of apoptotic process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density. Biomarker of several diseases, including alcohol dependence; brain infarction; drug psychosis; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human ARRB2 (arrestin beta 2); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arrestin beta-2; BARRES; beta-arrestin-2; MGC105502
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Arrb2-ps  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,645,539 - 55,653,485 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,645,357 - 55,653,487 (+)EnsemblGRCr8
mRatBN7.21055,146,887 - 55,154,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,146,818 - 55,154,850 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,825,196 - 59,833,080 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,313,709 - 59,321,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,812,911 - 54,820,795 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)Ensemblrn6Rnor6.0
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,285,120 - 54,301,063 (+)NCBICelera
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-arachidonoylglycerol  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
acetamide  (EXP)
acrolein  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alprenolol  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
antirheumatic drug  (ISO)
ATP  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
caffeine  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chrysin  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dobutamine  (ISO)
dopamine  (ISO)
Endomorphin-2  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etonitazene  (EXP)
fentanyl  (EXP,ISO)
fenthion  (ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
gentamycin  (EXP)
hydromorphone  (EXP)
ICI 118551  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
leukotriene D4  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
pamoic acid  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
propranolol  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
S-nitroso-L-cysteine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
cell chemotaxis  (ISO)
chemokine-mediated signaling pathway  (ISO)
circadian rhythm  (IEP)
desensitization of G protein-coupled receptor signaling pathway  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
endocytosis  (IDA,IEA)
follicle-stimulating hormone signaling pathway  (IDA,IEA)
G protein-coupled receptor internalization  (IBA,ISO)
G protein-coupled receptor signaling pathway  (IDA)
modulation of chemical synaptic transmission  (IBA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of GTPase activity  (IDA)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of opioid receptor signaling pathway  (IDA)
negative regulation of protein ubiquitination  (IMP)
negative regulation of release of cytochrome c from mitochondria  (IMP)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of calcium ion transport  (IMP)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of epithelial cell apoptotic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA,IMP,ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of opioid receptor signaling pathway  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP,ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of receptor internalization  (IMP,ISO)
positive regulation of synaptic transmission, dopaminergic  (ISO)
postsynaptic signal transduction  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein transport  (IEA)
protein ubiquitination  (ISO)
receptor internalization  (ISO)
regulation of G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of protein ubiquitination  (IEA)
response to morphine  (IEA,IEP)
sensory perception  (IEA)
sensory perception of pain  (IBA)
signal transduction  (IEA)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. Ahn S, etal., J Biol Chem. 2009 Mar 27;284(13):8855-65. Epub 2009 Jan 26.
2. Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. Attramadal H, etal., J Biol Chem 1992 Sep 5;267(25):17882-90.
3. β-arrestin 2 stimulates degradation of HIF-1α and modulates tumor progression of glioblastoma. Bae WY, etal., Cell Death Differ. 2021 Nov;28(11):3092-3104. doi: 10.1038/s41418-021-00802-2. Epub 2021 May 18.
4. Beta-arrestins: multifunctional cellular mediators. Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22.
5. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Beaulieu JM, etal., Cell. 2005 Jul 29;122(2):261-73.
7. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Beaulieu JM, etal., Cell. 2008 Jan 11;132(1):125-36. doi: 10.1016/j.cell.2007.11.041.
8. Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions. Bhattacharya A, etal., J Neurochem. 2010 Feb;112(3):723-32. Epub 2009 Nov 16.
9. Modulation of voluntary ethanol consumption by beta-arrestin 2. Björk K, etal., FASEB J. 2008 Jul;22(7):2552-60. doi: 10.1096/fj.07-102442. Epub 2008 Mar 26.
10. beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Boularan C, etal., Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18061-6. Epub 2007 Nov 5.
11. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
12. Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension. Chen W, etal., Int J Biol Sci. 2014 Mar 15;10(4):386-95. doi: 10.7150/ijbs.8081. eCollection 2014.
13. Cone arrestin identified by targeting expression of a functional family. Craft CM, etal., J Biol Chem 1994 Feb 11;269(6):4613-9.
14. Gender related alterations of beta-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058.
15. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
16. Differential regulation of beta-arrestin 1 and beta-arrestin 2 gene expression in rat brain by morphine. Fan XL, etal., Neuroscience. 2003;117(2):383-9. doi: 10.1016/s0306-4522(02)00930-2.
17. Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009.
18. c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization. Fessart D, etal., Mol Endocrinol. 2005 Feb;19(2):491-503. Epub 2004 Oct 21.
19. Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Gurevich EV, etal., Neuroscience. 2002;109(3):421-36.
23. Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons. Haberstock-Debic H, etal., J Neurosci. 2005 Aug 24;25(34):7847-57.
24. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79.
25. Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis. Hennenberg M, etal., Eur J Clin Invest. 2009 Oct;39(10):906-13. Epub 2009 Jun 12.
26. Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg M, etal., Hepatology. 2007 Feb;45(2):495-506.
27. Partial purification of a bone-resorbing factor elaborated from human allogeneic cultures. Horton JE, etal., Cell Immunol 1979 Mar 1;43(1):1-10.
28. β-Arrestin 2 (ARRB2) Polymorphism is Associated With Adverse Consequences of Chronic Heroin Use. Karavidha KK, etal., Am J Addict. 2021 Jul;30(4):351-357. doi: 10.1111/ajad.13150. Epub 2021 Mar 30.
29. Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats. Khan MS, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):85-94. Epub 2010 Dec 15.
30. Differential regulation of endosomal GPCR/ß-arrestin complexes and trafficking by MAPK. Khoury E, etal., J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.
31. Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. Kim J, etal., J Biol Chem. 2009 May 1;284(18):11953-62. Epub 2009 Mar 2.
32. PAF enhances MMP-2 production in rat aortic VSMCs via a beta-arrestin2-dependent ERK signaling pathway. Kim YH, etal., J Lipid Res. 2013 Oct;54(10):2678-86. doi: 10.1194/jlr.M037176. Epub 2013 Aug 2.
33. Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. Kyoi S, etal., Circ J. 2003 Aug;67(8):725-7.
34. Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. Li JB, etal., J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):877-85. doi: 10.1007/s11596-013-1215-7. Epub 2013 Dec 13.
35. Improvement of morphine-mediated analgesia by inhibition of β-arrestin2 expression in mice periaqueductal gray matter. Li Y, etal., Int J Mol Sci. 2009 Mar;10(3):954-63. doi: 10.3390/ijms10030954. Epub 2009 Mar 5.
36. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
37. Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons. Macey TA, etal., Mol Pharmacol. 2004 Dec;66(6):1635-42. Epub 2004 Sep 10.
38. G protein-coupled receptor kinase 2 and beta-arrestins are recruited to FSH receptor in stimulated rat primary Sertoli cells. Marion S, etal., J Endocrinol. 2006 Aug;190(2):341-50.
39. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. McDonald PH, etal., Science. 2000 Nov 24;290(5496):1574-7.
40. Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. McLennan GP, etal., J Neurochem. 2008 Dec;107(6):1753-65. doi: 10.1111/j.1471-4159.2008.05745.x. Epub 2008 Nov 10.
41. Disrupted circadian expression of β-arrestin 2 affects reward-related µ-opioid receptor function in alcohol dependence. Meinhardt MW, etal., J Neurochem. 2022 Feb;160(4):454-468. doi: 10.1111/jnc.15559. Epub 2022 Jan 4.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. Molla-Herman A, etal., PLoS One. 2008;3(11):e3728. Epub 2008 Nov 14.
44. G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Morris GE, etal., Cardiovasc Res. 2011 Jan 1;89(1):193-203. Epub 2010 Aug 12.
45. G protein-coupled receptor kinase 6/beta-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. Oda Y, etal., J Psychopharmacol. 2015 Dec;29(12):1308-13. doi: 10.1177/0269881115593903. Epub 2015 Jul 14.
46. β-Arrestin2 influences the response to methadone in opioid-dependent patients. Oneda B, etal., Pharmacogenomics J. 2011 Aug;11(4):258-66. doi: 10.1038/tpj.2010.37. Epub 2010 Jun 1.
47. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Perry SJ, etal., Science 2002 Oct 25;298(5594):834-6.
48. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. ¿-arrestin 1 (ARRDC1) and ß-arrestins cooperate to mediate Notch degradation in mammals. Puca L, etal., J Cell Sci. 2013 Oct 1;126(Pt 19):4457-68. doi: 10.1242/jcs.130500. Epub 2013 Jul 25.
52. GOA pipeline RGD automated data pipeline
53. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
54. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
55. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
56. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
57. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22.
58. Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50. Stanasila L, etal., Mol Pharmacol. 2008 Sep;74(3):562-73. Epub 2008 Jun 3.
59. Beta-arrestins 1 and 2 are associated with nicotine dependence in European American smokers. Sun D, etal., Mol Psychiatry. 2008 Apr;13(4):398-406. doi: 10.1038/sj.mp.4002036. Epub 2007 Jun 19.
60. Arrb2 causes hepatic lipid metabolism disorder via AMPK pathway based on metabolomics in alcoholic fatty liver. Sun YY, etal.
61. Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. Terrillon S, etal., Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1548-53. doi: 10.1073/pnas.0305322101. Epub 2004 Feb 2.
62. Biased agonism of the calcium-sensing receptor. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
63. {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism. Tzingounis AV, etal., Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21028-33. Epub 2010 Nov 15.
64. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
65. β-arrestin2 functions as a key regulator in the sympathetic-triggered immunodepression after stroke. Wang H, etal., J Neuroinflammation. 2018 Apr 10;15(1):102. doi: 10.1186/s12974-018-1142-4.
66. A G protein-coupled receptor kinase induces Xenopus oocyte maturation. Wang J and Liu XJ, J Biol Chem 2003 May 2;278(18):15809-14. Epub 2003 Feb 24.
67. The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony. Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19.
68. Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. Wang T, etal., J Hypertens. 2017 Mar;35(3):538-545. doi: 10.1097/HJH.0000000000001179.
69. Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Wang WY, etal., Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. Epub 2015 Nov 24.
70. ß-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis. Wang Y, etal., Am J Physiol Renal Physiol. 2017 Jul 1;313(1):F1-F8. doi: 10.1152/ajprenal.00588.2016. Epub 2017 Mar 8.
71. ß-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling. Wang Y, etal., Cardiovasc Res. 2017 Nov 1;113(13):1615-1626. doi: 10.1093/cvr/cvx147.
72. Antinociceptive potentiation and attenuation of tolerance by intrathecal {beta}-arrestin 2 small interfering RNA in rats. Yang CH, etal., Br J Anaesth. 2011 Nov;107(5):774-81. Epub 2011 Sep 17.
73. The contribution of rare and common variants in 30 genes to risk nicotine dependence. Yang J, etal., Mol Psychiatry. 2015 Nov;20(11):1467-78. doi: 10.1038/mp.2014.156. Epub 2014 Dec 2.
74. Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3.
75. Role of ssarrestins in bradykinin B2 receptor-mediated signalling. Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.
76. Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. Zoudilova M, etal., J Biol Chem. 2007 Jul 13;282(28):20634-46. Epub 2007 May 11.
Additional References at PubMed
PMID:9767391   PMID:10617462   PMID:10644702   PMID:11130073   PMID:11171997   PMID:12477932   PMID:12582207   PMID:12958028   PMID:12958365   PMID:14769794   PMID:15125834   PMID:15218143  
PMID:15489334   PMID:15501822   PMID:15611106   PMID:15635042   PMID:15878855   PMID:16325578   PMID:16368719   PMID:16378096   PMID:16820410   PMID:16903783   PMID:17456469   PMID:17513300  
PMID:17666399   PMID:18604210   PMID:19188335   PMID:19429870   PMID:19531493   PMID:19996297   PMID:22457824   PMID:22888001   PMID:23139825   PMID:23192415   PMID:23341447   PMID:23360390  
PMID:23382074   PMID:23576578   PMID:23816471   PMID:23873795   PMID:23884833   PMID:24974728   PMID:25081544   PMID:25081814   PMID:25542150   PMID:25972452   PMID:26157145   PMID:26398586  
PMID:26531813   PMID:26545496   PMID:26839314   PMID:27007854   PMID:27431999   PMID:27523794   PMID:27922111   PMID:28339772   PMID:28391016   PMID:28888936   PMID:29510185   PMID:29515120  
PMID:29563057   PMID:31269046   PMID:31612867   PMID:31948726   PMID:32471349   PMID:32579945   PMID:33025031  


Genomics

Comparative Map Data
Arrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,645,539 - 55,653,485 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,645,357 - 55,653,487 (+)EnsemblGRCr8
mRatBN7.21055,146,887 - 55,154,854 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,146,818 - 55,154,850 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,825,196 - 59,833,080 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,313,709 - 59,321,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,812,911 - 54,820,795 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)Ensemblrn6Rnor6.0
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,285,120 - 54,301,063 (+)NCBICelera
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Cytogenetic Map10q24NCBI
ARRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,710,632 - 4,721,497 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,710,393 - 4,721,500 (+)Ensemblhg38GRCh38
GRCh37174,613,927 - 4,624,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
T2T-CHM13v2.0174,600,371 - 4,611,146 (+)NCBIT2T-CHM13v2.0
Arrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,323,051 - 70,331,654 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,323,461 - 70,331,654 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381170,432,485 - 70,440,828 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,432,635 - 70,440,828 (+)Ensemblmm10GRCm38
MGSCv371170,246,155 - 70,254,176 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361170,248,893 - 70,257,018 (+)NCBIMGSCv36mm8
Celera1177,978,619 - 77,986,640 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Arrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,110,003 - 10,123,022 (+)Ensembl
ChiLan1.0NW_00495546710,109,985 - 10,118,687 (+)NCBIChiLan1.0ChiLan1.0
ARRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,328,333 - 12,339,069 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,296,695 - 14,307,332 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,757,048 - 4,767,517 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)EnsemblpanPan2panpan1.1
ARRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,831,208 - 31,838,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,829,864 - 31,839,454 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha531,968,270 - 31,977,918 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0531,934,052 - 31,943,706 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,934,872 - 31,943,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,900,361 - 31,910,009 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,860,046 - 31,869,691 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,036,284 - 32,045,935 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,719,545 - 52,727,921 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366773,172,925 - 3,181,520 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366773,173,054 - 3,181,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,161,778 - 52,170,342 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,280,938 - 54,286,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,191,040 - 4,202,382 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,191,172 - 4,202,385 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605917,439,881 - 17,451,765 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,568,198 - 8,577,914 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247868,568,102 - 8,576,445 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arrb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1950,043,684 - 50,051,664 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arrb2
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:54
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000026207
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF051457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000026207   ⟹   ENSRNOP00000026207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,645,430 - 55,653,483 (+)Ensembl
mRatBN7.2 Ensembl1055,146,818 - 55,154,850 (+)Ensembl
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108666   ⟹   ENSRNOP00000095625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,648,613 - 55,653,484 (+)Ensembl
mRatBN7.2 Ensembl1055,146,962 - 55,154,850 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133479   ⟹   ENSRNOP00000102697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,645,611 - 55,653,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162402   ⟹   ENSRNOP00000103308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,645,460 - 55,653,484 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171242   ⟹   ENSRNOP00000103352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,645,357 - 55,653,487 (+)Ensembl
RefSeq Acc Id: NM_012911   ⟹   NP_037043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,602 - 55,653,485 (+)NCBI
mRatBN7.21055,146,967 - 55,154,850 (+)NCBI
Rnor_6.01057,040,252 - 57,048,045 (+)NCBI
Rnor_5.01056,797,489 - 56,805,282 (+)NCBI
RGSC_v3.41057,244,071 - 57,284,166 (+)RGD
Celera1054,285,120 - 54,301,063 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085267   ⟹   XP_038941195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,569 - 55,653,485 (+)NCBI
mRatBN7.21055,146,918 - 55,154,854 (+)NCBI
RefSeq Acc Id: XM_039085269   ⟹   XP_038941197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,566 - 55,653,485 (+)NCBI
mRatBN7.21055,146,914 - 55,154,854 (+)NCBI
RefSeq Acc Id: XM_063268459   ⟹   XP_063124529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,653,485 (+)NCBI
RefSeq Acc Id: XM_063268460   ⟹   XP_063124530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,653,485 (+)NCBI
RefSeq Acc Id: XM_063268461   ⟹   XP_063124531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,653,120 (+)NCBI
RefSeq Acc Id: XM_063268462   ⟹   XP_063124532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,569 - 55,653,485 (+)NCBI
RefSeq Acc Id: XM_063268463   ⟹   XP_063124533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,653,485 (+)NCBI
RefSeq Acc Id: XM_063268464   ⟹   XP_063124534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,652,732 (+)NCBI
RefSeq Acc Id: XR_005489692
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,653,062 (+)NCBI
mRatBN7.21055,146,888 - 55,154,431 (+)NCBI
RefSeq Acc Id: XR_010055130
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,645,539 - 55,651,557 (+)NCBI
RefSeq Acc Id: NP_037043   ⟸   NM_012911
- UniProtKB: P29067 (UniProtKB/Swiss-Prot),   A6HG47 (UniProtKB/TrEMBL),   A0A8L2QE39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026207   ⟸   ENSRNOT00000026207
RefSeq Acc Id: XP_038941197   ⟸   XM_039085269
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038941195   ⟸   XM_039085267
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QE39 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095625   ⟸   ENSRNOT00000108666
RefSeq Acc Id: XP_063124530   ⟸   XM_063268460
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QE39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124533   ⟸   XM_063268463
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QE39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124529   ⟸   XM_063268459
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QE39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124531   ⟸   XM_063268461
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QE39 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124534   ⟸   XM_063268464
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063124532   ⟸   XM_063268462
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000103308   ⟸   ENSRNOT00000162402
Ensembl Acc Id: ENSRNOP00000103352   ⟸   ENSRNOT00000171242
Ensembl Acc Id: ENSRNOP00000102697   ⟸   ENSRNOT00000133479
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29067-F1-model_v2 AlphaFold P29067 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697358
Promoter ID:EPDNEW_R7881
Type:initiation region
Name:Arrb2_1
Description:arrestin, beta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01057,040,245 - 57,040,305EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2157 AgrOrtholog
BioCyc Gene G2FUF-24462 BioCyc
Ensembl Genes ENSRNOG00000019308 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026207 ENTREZGENE
  ENSRNOT00000108666 ENTREZGENE
  ENSRNOT00000133479 ENTREZGENE
  ENSRNOT00000162402 ENTREZGENE
  ENSRNOT00000171242 ENTREZGENE
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
  2.60.40.840 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7311618 IMAGE-MGC_LOAD
InterPro Arrestin UniProtKB/Swiss-Prot
  Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_CS UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:25388 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105502 IMAGE-MGC_LOAD
NCBI Gene 25388 ENTREZGENE
PANTHER BETA-ARRESTIN-2 UniProtKB/Swiss-Prot
  PTHR11792 UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Arrb2 PhenoGen
PRINTS ARRESTIN UniProtKB/Swiss-Prot
PROSITE ARRESTINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019308 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
UniProt A0A8I6APG4_RAT UniProtKB/TrEMBL
  A0A8L2QE39 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L2A2_RAT UniProtKB/TrEMBL
  A0ABK0LNI3_RAT UniProtKB/TrEMBL
  A0ABK0LQB3_RAT UniProtKB/TrEMBL
  A6HG47 ENTREZGENE, UniProtKB/TrEMBL
  ARRB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Arrb2  Arrestin, beta 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to postsynaptic sites 631708
gene_expression expressed in neuronal tissues and in the spleen 631708
gene_function multivalent adaptor protein 631708
gene_function multivalent adaptor protein 631798
gene_homology has 78% amino acid identity with beta-arrestin1 631708
gene_process involved in desensitization of the 2-adrenergic receptor and in the recruitment of a variety of cytosolic proteins to their sites of action at the plasma membrane 631798
gene_process may work with beta ARK to regulate G protein-coupled neurotransmitter receptors 631708