PARATHYROID HORMONE SIGNALING PATHWAY (PW:0001135)

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Description

The signaling initiated by the parathyroid hormone (PTH) plays a central role in calcium (Ca2+) and phosphate homeostasis. In response to low Ca2+, the hormone is secreted from the parathyroid glands; high Ca2+ levels activate the Ca2+ sensing receptor whose signaling inhibits its secretion. In the kidney, PTH regulates Ca2+ and phosphate reabsorption: specifically, it increases Ca2+ reabsorption leading to increased release of the metal into the circulation; it diminishes phosphate absorption

Pathway Diagram:

Ariadne Genomics Inc. Pth --+> Ca2+ reabsorption Pth ---> anabolic, catabolic effects on bone phosphate reabsoprtion activation of adenylyl cyclases/increased cAMP --+> protein kinase A (PKA) signaling pathway cAMP increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway IP3 DAG Slc34a1 phosphate transport pathway anabolic, catabolic effects on bone Pth1r partners G protein mediated signaling pathway via Galphas family ---> activation of adenylyl cyclases/increased cAMP Arrb1 ---- Pth1r Arrb2 ---- Pth1r Arrb1 Adrbk1 Pth1r ---- Pth1r partners Pth1r ---- Slc9a3r2 Slc9a3r2 Ezr ---- Pth1r Ezr Ezr ---- Slc9a3r1 Pth1r ---- Slc9a3r1 Slc9a3r1 calcium signaling pathway via the calcium-sensing receptor ---| Pth protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphaq family activation of adenylyl cyclases/increased cAMP protein kinase C (PKC) signaling pathway Adrbk1 ---| Pth1r Arrb2 Ca2+ G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Pth ---- Pth1r Ca2+ --+> Pth calcium signaling pathway via the calcium-sensing receptor Ca2+ --+> calcium signaling pathway via the calcium-sensing receptor increased DAG/IP3 via PLC activation Pth ---| phosphate reabsoprtion Pth ---| phosphate transport pathway Pth Ca2+ reabsorption Slc34a1 ---- Slc9a3r1 Pth1r --+> G protein mediated signaling pathway via Galphas family Pth1r Pth1r --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphas family
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Genes in Pathway:

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parathyroid hormone signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207469
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207469
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:7207465
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207470
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7207455
RGD:7207470
RGD:7207465
G Pth1r parathyroid hormone 1 receptor JBrowse link 8 118,984,531 119,012,803 RGD:7207455
RGD:7207470
RGD:7207469
RGD:7207465
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:7207465
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:7207465

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupPth1r partners

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the parathyroid hormone signaling pathway
Phenotype Annotations Associated with Genes in the parathyroid hormone signaling pathway

References Associated with the parathyroid hormone signaling pathway:

Ontology Path Diagram:

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