PARATHYROID HORMONE SIGNALING PATHWAY (PW:0001135)

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Description

The signaling initiated by the parathyroid hormone (PTH) plays a central role in calcium (Ca2+) and phosphate homeostasis. In response to low Ca2+, the hormone is secreted from the parathyroid glands; high Ca2+ levels activate the Ca2+ sensing receptor whose signaling inhibits its secretion. In the kidney, PTH regulates Ca2+ and phosphate reabsorption: specifically, it increases Ca2+ reabsorption leading to increased release of the metal into the circulation; it diminishes phosphate absorption

Pathway Diagram:

Ariadne Genomics Inc. Pth --+> Ca2+ reabsorption Pth ---> anabolic, catabolic effects on bone phosphate reabsoprtion activation of adenylyl cyclases/increased cAMP --+> protein kinase A (PKA) signaling pathway cAMP increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway IP3 DAG Slc34a1 phosphate transport pathway anabolic, catabolic effects on bone Pth1r partners G protein mediated signaling pathway via Galphas family ---> activation of adenylyl cyclases/increased cAMP Arrb1 ---- Pth1r Arrb2 ---- Pth1r Arrb1 Adrbk1 Pth1r ---- Pth1r partners Pth1r ---- Slc9a3r2 Slc9a3r2 Ezr ---- Pth1r Ezr Ezr ---- Slc9a3r1 Pth1r ---- Slc9a3r1 Slc9a3r1 calcium signaling pathway via the calcium-sensing receptor ---| Pth protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphaq family activation of adenylyl cyclases/increased cAMP protein kinase C (PKC) signaling pathway Adrbk1 ---| Pth1r Arrb2 Ca2+ G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Pth ---- Pth1r Ca2+ --+> Pth calcium signaling pathway via the calcium-sensing receptor Ca2+ --+> calcium signaling pathway via the calcium-sensing receptor increased DAG/IP3 via PLC activation Pth ---| phosphate reabsoprtion Pth ---| phosphate transport pathway Pth Ca2+ reabsorption Slc34a1 ---- Slc9a3r1 Pth1r --+> G protein mediated signaling pathway via Galphas family Pth1r Pth1r --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphas family
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Genes in Pathway:

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parathyroid hormone signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207469
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207469
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:7207465
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207470
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7207455
RGD:7207470
RGD:7207465
G Pth1r parathyroid hormone 1 receptor JBrowse link 8 118,984,531 119,012,803 RGD:7207455
RGD:7207470
RGD:7207469
RGD:7207465
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:7207465
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:7207465

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupPth1r partners

Pathway Gene Annotations

Disease Annotations Associated with Genes in the parathyroid hormone signaling pathway
Disease TermsGene Symbols
AlbuminuriaPth
Amphetamine-Related DisordersArrb2
AnemiaPth
Aortic Valve, Calcification ofPth
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2
Arthritis, RheumatoidGrk2
Atrial FibrillationPth
Basal Cell Nevus SyndromePth
Bone Diseases, EndocrinePth
Bone ResorptionPth
CarcinomaEzr
Carcinoma, Ductal, BreastSlc9a3r1
CardiomegalyGrk2
CardiomyopathiesGrk2
Cardiovascular DiseasesGrk2
Chondrodysplasia, Blomstrand TypePth1r
ColitisArrb1
Congenital AbnormalitiesGrk2
Coronary Artery DiseasePth
Dermatitis, Allergic ContactGrk2
Diabetes Mellitus, Type 1Pth
Diabetes Mellitus, Type 2Pth
Diabetic NephropathiesPth
Eiken Skeletal DysplasiaPth1r
Embryo LossGrk2
Failure of Tooth Eruption, PrimaryPth1r
Fractures, BonePth
Gastritis, AtrophicPth
Heart FailureArrb1 , Grk2 , Pth
HypercalcemiaPth , Pth1r
HypercalciuriaPth
Hypercalciuric Hypocalcemia, FamilialPth
HyperglycemiaGrk2
HyperostosisPth
HyperparathyroidismPth1r
Hyperparathyroidism, PrimaryPth
Hyperparathyroidism, SecondaryPth
HyperphosphatemiaPth
HypertensionGrk2 , Pth , Slc9a3r1 , Slc9a3r2
Hypertension, PortalGrk2
Hypertrophy, Left VentricularGrk2 , Pth
HypocalcemiaPth
Hypoparathyroidism Familial IsolatedPth
Hypoparathyroidism, Autosomal RecessivePth
Hypophosphatemic Rickets with Hypercalciuria, HereditaryPth
Insulin ResistanceGrk2
Jansen Type Metaphyseal ChondrodysplasiaPth1r
Kidney Failure, ChronicPth
Liver CirrhosisArrb1
Liver Cirrhosis, ExperimentalArrb2 , Ezr , Grk2
Liver Neoplasms, ExperimentalArrb2
Lung DiseasesPth1r
Mammary Neoplasms, AnimalEzr
Mammary Neoplasms, ExperimentalEzr
Neoplasm MetastasisEzr
NephrocalcinosisPth
NephrolithiasisPth
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2Slc9a3r1
OsteoarthritisEzr
OsteochondrodysplasiasPth1r
OsteoporosisPth
Osteoporosis, PostmenopausalPth
OsteosarcomaPth
Otitis MediaPth
Parathyroid NeoplasmsPth
Parkinson DiseaseGrk2
PhosphaturiaPth
Prostatic NeoplasmsEzr
Renal Insufficiency, ChronicPth
Renal OsteodystrophyPth
RicketsPth , Pth1r
SepsisGrk2
Smith-Magenis SyndromeSlc9a3r1
StrokePth
Tibial FracturesPth
UremiaPth
Vascular CalcificationPth
Pathway Annotations Associated with Genes in the parathyroid hormone signaling pathway

References Associated with the parathyroid hormone signaling pathway:

Ontology Path Diagram:

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