RGD Reference Report - Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. - Rat Genome Database

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Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.

Authors: Vilardaga, JP  Romero, G  Friedman, PA  Gardella, TJ 
Citation: Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
RGD ID: 7207469
Pubmed: PMID:20703892   (View Abstract at PubMed)
PMCID: PMC3568769   (View Article at PubMed Central)
DOI: DOI:10.1007/s00018-010-0465-9   (Journal Full-text)

The parathyroid hormone (PTH) receptor type 1 (PTHR), a G protein-coupled receptor (GPCR), transmits signals to two hormone systems-PTH, endocrine and homeostatic, and PTH-related peptide (PTHrP), paracrine-to regulate different biological processes. PTHR responds to these hormonal stimuli by activating heterotrimeric G proteins, such as G(S) that stimulates cAMP production. It was thought that the PTHR, as for all other GPCRs, is only active and signals through G proteins on the cell membrane, and internalizes into a cell to be desensitized and eventually degraded or recycled. Recent studies with cultured cell and animal models reveal a new pathway that involves sustained cAMP signaling from intracellular domains. Not only do these studies challenge the paradigm that cAMP production triggered by activated GPCRs originates exclusively at the cell membrane but they also advance a comprehensive model to account for the functional differences between PTH and PTHrP acting through the same receptor.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Arrb1  (arrestin, beta 1)
Arrb2  (arrestin, beta 2)
Pth1r  (parathyroid hormone 1 receptor)

Genes (Mus musculus)
Arrb1  (arrestin, beta 1)
Arrb2  (arrestin, beta 2)
Pth1r  (parathyroid hormone 1 receptor)

Genes (Homo sapiens)
ARRB1  (arrestin beta 1)
ARRB2  (arrestin beta 2)
PTH1R  (parathyroid hormone 1 receptor)


Additional Information