CALCIUM SIGNALING PATHWAY VIA THE CALCIUM-SENSING RECEPTOR (PW:0001141)

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Description

Calcium (Ca2+) signaling via the calcium-sensing receptor (Casr) exerts important roles in calcium homeostasis; it inhibits the secretion of parathyroid hormone (PTH) in parathyroid glands and regulates calcium absorption and water balance in the kidney, the two tissues where the receptor is most abundantly expressed. The function of Casr is also important for the proper functioning of cells involved in bone remodeling and of many types of neural cells, among others. In addition to Ca2+, the re

Pathway Diagram:

Ariadne Genomics Inc. Arrb2 Arrb1 G protein mediated signaling pathway via Galphai family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway DAG IP3 Flna Rhoa increased DAG/IP3 via PLC activation Arrb2 ---- Casr Arrb1 ---- Casr Casr ---| parathyroid hormone signaling pathway Casr ---| PTH secretion Ca absoprtion, water balance calcimimetics ---- Casr calcilytics ---- Casr calcimimetics --+> Casr calcilytics ---| Casr Ca2+ ---- Casr G protein mediated signaling pathway via Galphaq family ---> increased DAG/IP3 via PLC activation Casr ---- Casr binding partners Casr ---> Ca absoprtion, water balance Casr --+> G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphaq family --+> Rho/Rac/Cdc42 mediated signaling pathway G protein mediated signaling pathway via Galpha12/Galpha13 family --+> Rho/Rac/Cdc42 mediated signaling pathway inhibition of adenylyl cyclases/decreased cAMP G protein mediated signaling pathway via Galphai family ---> inhibition of adenylyl cyclases/decreased cAMP RGS proteins ---| G protein mediated signaling pathway via Galphai family Arrb1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Arrb2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr RGS proteins ---| G protein mediated signaling pathway via Galphaq family RGS proteins ---| G protein mediated signaling pathway via Galpha12/Galpha13 family Casr ---- Flna G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galpha12/Galpha13 family Rho/Rac/Cdc42 mediated signaling pathway protein kinase C (PKC) signaling pathway parathyroid hormone signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway Casr binding partners GRKs RGS proteins receptor desensitization PTH secretion calcimimetics calcilytics Ca2+ Casr --+> G protein mediated signaling pathway via Galphai family Casr --+> G protein mediated signaling pathway via Galpha12/Galpha13 family G protein mediated signaling pathway via Galphaq family --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway increased DAG/IP3 via PLC activation --+> protein kinase C (PKC) signaling pathway GRKs ---| Casr
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Genes in Pathway:

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calcium signaling pathway via the calcium-sensing receptor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7207059
RGD:7207060
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7207059
RGD:7207060
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:7207059
RGD:7207060
RGD:7207227
G Flna filamin A JBrowse link X 156,460,785 156,487,245 RGD:7207227
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:7207060
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:7207060
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:7207060
G Rgs12 regulator of G-protein signaling 12 JBrowse link 14 80,975,239 81,069,519 RGD:7207227
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:7207227
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:7207227
G Rgs5 regulator of G-protein signaling 5 JBrowse link 13 87,966,820 88,002,831 RGD:7207228
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:7207227

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassGRKsG-protein coupled kinases
Gene GroupCasr binding partnersOther proteins interacting with Casr
Functional ClassRGS proteinsRegulators of G-protein signaling

Pathway Gene Annotations

Disease Annotations Associated with Genes in the calcium signaling pathway via the calcium-sensing receptor
Disease TermsGene Symbols
Abnormalities, Drug-InducedRhoa
Adenocarcinoma of LungRhoa
AlbuminuriaCasr
Amphetamine-Related DisordersArrb2
AnoxiaCasr
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2
Arthritis, RheumatoidGrk2
AsthmaRhoa
AtherosclerosisCasr
Bipolar DisorderGrk3
Brain InjuriesRhoa
Breast NeoplasmsFlna , Rgs2 , Rhoa
CarcinomaRhoa
Carcinoma, Squamous Cell of Head and NeckRhoa
Cardiac Valvular Dysplasia, X-LinkedFlna
CardiomegalyGrk2 , Grk3 , Rhoa
CardiomyopathiesCasr , Grk2
Cardiovascular DiseasesGrk2
Cleft PalateFlna
ColitisArrb1
Colorectal NeoplasmsRhoa
Congenital AbnormalitiesGrk2
Congenital Idiopathic Intestinal PseudoobstructionFlna
CraniosynostosesFlna
Dermatitis, Allergic ContactGrk2
Diabetes Mellitus, ExperimentalCasr , Rhoa
Diabetic CardiomyopathiesCasr
Disease Models, AnimalRhoa
Embryo LossGrk2
Encephalomyelitis, Autoimmune, ExperimentalRhoa
EndometriosisRgs4
EpilepsyFlna
Epilepsy, Idiopathic GeneralizedCasr
Fetal Alcohol SyndromeRhoa
FibrosisRhoa
Frontometaphyseal DysplasiaFlna
Glomerulonephritis, MembranousRhoa
Hearing Loss, ConductiveFlna
Heart FailureArrb1 , Grk2
Hernias, Diaphragmatic, CongenitalRhoa
Heterotopia, Periventricular, Ehlers-Danlos VariantFlna
HypercalcemiaCasr
HypercalciuriaCasr
Hypercalciuric HypercalcemiaCasr
Hypercalciuric Hypocalcemia, FamilialCasr
HyperglycemiaGrk2
HyperparathyroidismCasr
Hyperparathyroidism, Neonatal Severe PrimaryCasr
Hyperparathyroidism, PrimaryCasr
Hyperparathyroidism, SecondaryCasr
HypertensionGrk2 , Rgs2 , Rgs5 , Rhoa
Hypertension, EssentialGrk4 , Rgs5
Hypertension, PortalGrk2
Hypertension, PulmonaryCasr , Rhoa
Hypertrophy, Left VentricularGrk2 , Rhoa
HypocalcemiaCasr
Hypocalcemia, Autosomal Dominant, with Bartter SyndromeCasr
Hypocalciuric Hypercalcemia, Familial, Type 1Casr
HypoparathyroidismCasr
Hypoparathyroidism Familial IsolatedCasr
HypothyroidismGrk3
Immunoblastic LymphadenopathyRhoa
Insulin ResistanceGrk2
Intellectual DisabilityCasr
Intestinal Pseudo-ObstructionFlna
Kidney Failure, ChronicCasr
Leukemia, Myeloid, AcuteRgs2
Liver CirrhosisArrb1
Liver Cirrhosis, ExperimentalArrb2 , Flna , Grk2 , Rgs2 , Rgs5 , Rhoa
Liver Neoplasms, ExperimentalArrb2
Lymphatic MetastasisRhoa
Lymphoma, Non-HodgkinRhoa
Lymphoma, T-CellRhoa
Lymphoma, T-Cell, CutaneousRhoa
Lymphoma, T-Cell, PeripheralRhoa
Malformations of Cortical Development, Group IIFlna
Mitral Valve ProlapseFlna
Multiple SclerosisRhoa
Myocardial InfarctionCasr
Myocardial Reperfusion InjuryCasr , Rhoa
Neoplasm InvasivenessRhoa
Neoplasm MetastasisRhoa
Neoplasms, Germ Cell and EmbryonalRhoa
NephrolithiasisCasr
Nephrolithiasis, Calcium OxalateCasr
Neuritis, Autoimmune, ExperimentalRhoa
ObesityRhoa
Opitz-Kaveggia SyndromeFlna
Optic Nerve InjuriesRhoa
OsteochondrodysplasiasFlna
Oto-Palato-Digital Syndrome Type 1Flna
Oto-Palato-Digital Syndrome, Type 2Flna
Otopalatodigital Spectrum DisorderFlna
Ovarian NeoplasmsRhoa
Parkinson DiseaseGrk2 , Grk3
Parkinson Disease, SecondaryRgs2
Periventricular Nodular HeterotopiaFlna
Phyllodes TumorFlna
Prostatic NeoplasmsCasr
ProteinuriaRhoa
RicketsCasr
SchizophreniaRgs12 , Rgs4
SepsisGrk2
Stomach NeoplasmsRgs2 , Rhoa
Terminal Osseous DysplasiaFlna
Tuberous SclerosisFlna
Urinary Bladder NeoplasmsRhoa
Urologic NeoplasmsRhoa
Pathway Annotations Associated with Genes in the calcium signaling pathway via the calcium-sensing receptor
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2 , Rgs2 , Rgs4
angiotensin II signaling pathway via AT1 receptorArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2
calcium signaling pathway via the calcium-sensing receptorArrb1 , Arrb2 , Casr , Flna , Grk2 , Grk3 , Grk4 , Rgs12 , Rgs2 , Rgs4 , Rgs5 , Rhoa
chemokine mediated signaling pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk4 , Rhoa
colorectal cancer pathwayRhoa
corticotropin-releasing hormone signaling pathwayArrb1 , Arrb2 , Grk3
dopamine signaling pathway via D1 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2 , Rgs4
dopamine signaling pathway via D2 family of receptorsArrb1 , Arrb2 , Grk2 , Grk3 , Rgs2 , Rgs4
E-cadherin signaling pathwayCasr , Rhoa
eicosanoid signaling pathwayArrb2 , Grk2 , Grk3 , Rhoa
endocytosis pathwayArrb1 , Arrb2 , Grk2 , Grk3 , Grk4 , Rhoa
endothelin signaling pathwayRhoa
ephrin - ephrin receptor bidirectional signaling axisRhoa
epinephrine signaling pathway via adrenergic receptor betaArrb1 , Arrb2 , Grk2
G protein mediated signaling pathway via Galpha12/Galpha13 familyCasr , Rgs12
G protein mediated signaling pathway via Galphai familyCasr , Rgs2 , Rgs4 , Rgs5
G protein mediated signaling pathway via Galphaq familyCasr , Rgs2 , Rgs4 , Rgs5
G protein mediated signaling pathway via Galphas familyGrk2 , Grk3 , Rgs2 , Rgs4
glutamate signaling pathwayGrk2 , Grk3
Hedgehog signaling pathwayArrb2 , Grk2
integrin mediated signaling pathwayFlna
interleukin-2 signaling pathwayRhoa
kinin signaling pathwayArrb1 , Arrb2 , Grk4
mitogen activated protein kinase signaling pathwayArrb1 , Arrb2 , Flna
mTOR signaling pathwayRhoa
Mycobacterium tuberculosis infection pathwayRhoa
N-cadherin signaling pathwayRhoa
neurotrophic factor signaling pathwayRhoa
nuclear factor kappa B signaling pathwayArrb2
parathyroid hormone signaling pathwayArrb1 , Arrb2 , Grk2
phosphatidylinositol 3-kinase class I signaling pathwayRhoa
platelet-derived growth factor signaling pathwayRhoa
Rho/Rac/Cdc42 mediated signaling pathwayFlna , Rhoa
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa
T cell receptor signaling pathwayRhoa
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Rhoa
transforming growth factor-beta superfamily mediated signaling pathwayRhoa
vascular endothelial growth factor signaling pathwayRhoa
visual phototransduction pathwayArrb1 , Arrb2
Wnt signaling pathwayRhoa
Wnt signaling, non-canonical pathwayArrb2 , Flna , Rhoa
Wnt signaling, the planar cell polarity pathwayRhoa

References Associated with the calcium signaling pathway via the calcium-sensing receptor:

Ontology Path Diagram:

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