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The kallikrein-kinin (KKS) cascade pathway generates the active kinin peptides. Kinin signaling plays important roles in the cardiovascular, renal, respiratory and nervous systems. It elicits vasodilator, inflammatory and pain responses and it exert both proliferating and anti-proliferating effects. The active kinin peptides bradykinin (BK), kallidin (KD) and their C-terminal processed des-Arg-metabolites signal via two G-protein coupled (GPCR) receptors, known as B1R and B2R, encoded by Bdkrb1

Pathway Diagram:

Elsevier Inc. des-Arg-kinins ---> vasodilation vasodilation des-Arg-kinins des-Arg-kinins ---> heart function Ca2+ --+> NO Ca2+ --+> arachidonic acid protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway G protein mediated signaling pathway via Galphaq family --+> DAG G protein mediated signaling pathway via Galphaq family --+> IP3 IP3 Ca2+ calcium/calcium-mediated signaling pathway G protein mediated signaling pathway via Galphaq family G protein mediated signaling pathway via Galphai family BK Arrb2 ---- Bdkrb2 GRK4 ---> Bdkrb2 GRK4 heart function perception of pain BK ---> kidney function IP3 --+> Ca2+ DAG --+> protein kinase C (PKC) signaling pathway Arrb1 ---- Bdkrb2 Arrb1 Arrb2 Bdkrb2 ---- KD Bdkrb1 ---- des-Arg-kinins Bdkrb2 ---- BK kidney function Bdkrb1 Bdkrb2 KD ---> perception of pain Ca2+ --+> protein kinase C (PKC) signaling pathway KD DAG arachidonic acid NO calcium transport pathway protein kinase C (PKC) signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway kallikrein-kinin cascade pathway G protein independent events

Genes in Pathway:

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kinin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:7411621
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:7411621
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:7401223
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:7401223
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:7401225
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:7401223

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinBKbradykinin generated via the kallikrein-kinin pathway
ProteinKDkallidin generated via the kallikrein-kinin pathway
Proteindes-Arg-kininthe kinins further derived from BK and KD in the kallikrein-kinin pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the kinin signaling pathway
Disease TermsGene Symbols
Acquired AngioedemaKng2
Acute Kidney InjuryBdkrb2 , Kng2
Amphetamine-Related DisordersArrb2
Angina, UnstableBdkrb1
Angioedemas, HereditaryKng2
Arrhythmias, CardiacKng2
Arteriovenous FistulaArrb1 , Arrb2
Arthritis, ExperimentalArrb1 , Arrb2 , Kng2
Arthritis, RheumatoidBdkrb2
Branched-Chain Ketoacid Dehydrogenase Kinase DeficiencyKng2
Chemical and Drug Induced Liver InjuryKng2
CoughBdkrb2 , Kng2
Death, Sudden, CardiacKng2
Diabetes ComplicationsBdkrb1 , Bdkrb2
Diabetes Mellitus, ExperimentalBdkrb1 , Bdkrb2
Diabetic AngiopathiesBdkrb1
Diabetic NephropathiesBdkrb2 , Kng2
Diabetic NeuropathiesBdkrb1
Diabetic RetinopathyBdkrb1 , Bdkrb2
Drug EruptionsKng2
EdemaBdkrb1 , Kng2
EosinophiliaBdkrb2 , Kng2
EpilepsyBdkrb1 , Bdkrb2
Epilepsy, Temporal LobeBdkrb1 , Bdkrb2
Extravasation of Diagnostic and Therapeutic MaterialsBdkrb2 , Kng2
Flaujeac Factor DeficiencyKng2
Glomerulosclerosis, Focal SegmentalBdkrb1
Heart FailureArrb1
HyperalgesiaBdkrb1 , Bdkrb2 , Kng2
HyperemiaBdkrb2 , Kng2
HypertensionBdkrb1 , Bdkrb2 , Kng2
Hypertension, EssentialGrk4
Hypertension, PortalBdkrb2
Hypertension, PulmonaryBdkrb2
Hypertrophy, Left VentricularBdkrb1 , Bdkrb2
HypotensionBdkrb2 , Kng2
InflammationBdkrb1 , Bdkrb2
Insulin ResistanceBdkrb1
Kidney Failure, ChronicBdkrb1
Kidney Reperfusion InjuryBdkrb1
Leukemia, Myeloid, AcuteBdkrb1 , Bdkrb2
Liver CirrhosisArrb1
Liver Cirrhosis, ExperimentalArrb2 , Kng2
Liver Neoplasms, ExperimentalArrb2
Lung DiseasesBdkrb2
Mammary Neoplasms, AnimalKng2
Microvascular AnginaBdkrb1 , Bdkrb2
Myocardial InfarctionBdkrb1 , Bdkrb2
Myocardial Reperfusion InjuryKng2
PainBdkrb1 , Bdkrb2 , Kng2
PleurisyBdkrb1 , Bdkrb2
Primary MyelofibrosisBdkrb1 , Bdkrb2
Pulmonary Disease, Chronic ObstructiveBdkrb2
Pulmonary FibrosisBdkrb1
Purpura, Schoenlein-HenochKng2
Renal FibrosisBdkrb1
RhinitisBdkrb1 , Bdkrb2
Sciatic NeuropathyBdkrb1 , Bdkrb2
Thrombocythemia, EssentialBdkrb1 , Bdkrb2
Urinary Bladder, OveractiveBdkrb1
Vascular System InjuriesBdkrb1 , Bdkrb2
Venous ThromboembolismKng2
Vitreoretinopathy, ProliferativeKng2
Pathway Annotations Associated with Genes in the kinin signaling pathway
Phenotype Annotations Associated with Genes in the kinin signaling pathway

References Associated with the kinin signaling pathway:

Ontology Path Diagram:

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