Abcc3 (ATP binding cassette subfamily C member 3) - Rat Genome Database

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Gene: Abcc3 (ATP binding cassette subfamily C member 3) Rattus norvegicus
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Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
RGD ID: 71101
Description: Enables ABC-type bile acid transporter activity. Involved in several processes, including bile acid and bile salt transport; response to estradiol; and response to tetrachloromethane. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of bilirubin metabolic disorder (multiple); cholestasis; hyperprolactinemia; kidney disease (multiple); and liver disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; MLP-2; Mlp2; MRP-like protein 2; Mrp3; multidrug resistance protein 3; multidrug resistance-associated protein 3; organic anion transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1079,793,583 - 79,839,494 (-)EnsemblGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)Ensemblrn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+/-)-Aegeline  (ISO)
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Epidiosbulbin E acetate  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetaminophen O-beta-D-glucosiduronic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
amikacin  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (EXP)
antimonite  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
azathioprine  (EXP)
Azoxymethane  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[b]fluorene  (EXP)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
brequinar  (ISO)
bromobenzene  (EXP)
buserelin  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcein am  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefalotin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysin  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clothianidin  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
Diglycolic acid  (EXP,ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
diosgenin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
doxycycline  (EXP)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (EXP,ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
etoposide  (ISO)
felbamate  (EXP)
fenofibrate  (EXP)
fentin chloride  (EXP)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP,ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geneticin  (ISO)
genistein  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyburide  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
GW 4064  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
inulin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (EXP,ISO)
lead(0)  (ISO)
leukotriene C4  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (ISO)
macitentan  (ISO)
Meclizine  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methylarsonic acid  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
metyrapone  (ISO)
mifepristone  (ISO)
MK 571  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzoylglycine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
naloxone  (EXP)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nickel sulfate  (ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nocodazole  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
parthenolide  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (ISO)
physcion  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (EXP,ISO)
pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (ISO)
prochloraz  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (EXP,ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
spironolactone  (EXP,ISO)
stilbene oxide  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
theophylline  (ISO)
thiacloprid  (EXP,ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thiram  (ISO)
ticlopidine  (EXP,ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
vincristine  (ISO)
yohimbine  (ISO)
zafirlukast  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basal plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IBA,IDA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Akita H, etal., Pharm Res. 2002 Jan;19(1):34-41.
2. Manifestation of multidrug resistance protein 3 (MRP3) in liver and kidney cells in cholestasis: effects of hyperprolactinemia. Aleksandrova MI, etal., Bull Exp Biol Med. 2013 Feb;154(4):508-11.
3. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
4. Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. Bodo A, etal., J Biol Chem 2003 Jun 27;278(26):23529-37.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
8. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Hardwick RN, etal., Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23.
9. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
10. ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). Hirohashi T, etal., J Biol Chem. 2000 Jan 28;275(4):2905-10. doi: 10.1074/jbc.275.4.2905.
11. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75.
12. Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3. Kobayashi K, etal., Pharmacogenet Genomics. 2008 Sep;18(9):823-33. doi: 10.1097/FPC.0b013e328306e9ae.
13. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Konig J, etal., Hepatology 1999 Apr;29(4):1156-63.
14. Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. Konig J, etal., Int J Cancer. 2005 Jun 20;115(3):359-67.
15. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
16. Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Li T, etal., Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G602-10.
17. Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. Lickteig AJ, etal., Drug Metab Dispos. 2007 Oct;35(10):1970-8. Epub 2007 Jul 19.
18. Gender differences in mRNA expression of ATP-binding cassette efflux and bile acid transporters in kidney, liver, and intestine of 5/6 nephrectomized rats. Lu H and Klaassen C, Drug Metab Dispos. 2008 Jan;36(1):16-23. Epub 2007 Sep 12.
19. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
20. Induction of drug metabolism enzymes and transporters by oltipraz in rats. Merrell MD, etal., J Biochem Mol Toxicol. 2008;22(2):128-35.
21. Gene Data Set MGD Curation, June 12, 2002
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats. Muguruma M, etal., Arch Toxicol. 2008 Jul 22.
24. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Tienilic acid enhances hyperbilirubinemia in Eisai hyperbilirubinuria rats through hepatic multidrug resistance-associated protein 3 and heme oxygenase-1 induction. Nishiya T, etal., Toxicol Sci. 2006 Jun;91(2):651-9. Epub 2006 Mar 16.
27. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Okumura H, etal., Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3.
28. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte. Ortiz DF, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):G1493-500.
29. Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats. Petrovic V, etal., Drug Metab Dispos. 2008 Sep;36(9):1944-50. Epub 2008 May 27.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Rost D, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G720-6.
36. Ethynylestradiol increases expression and activity of rat liver MRP3. Ruiz ML, etal., Drug Metab Dispos. 2006 Jun;34(6):1030-4. Epub 2006 Mar 22.
37. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
38. Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats. Villanueva SS, etal., Drug Metab Dispos. 2008 Mar;36(3):475-80. Epub 2007 Dec 20.
39. Differential Expression of Ion Channels and Transporters During Hepatocellular Carcinoma Development. Zuniga-Garcia V, etal., Dig Dis Sci. 2015 Aug;60(8):2373-83. doi: 10.1007/s10620-015-3633-9. Epub 2015 Apr 5.
Additional References at PubMed
PMID:11846400   PMID:12951053   PMID:14724430   PMID:14981926   PMID:16946557   PMID:19334674   PMID:22015764   PMID:23077105   PMID:25931508   PMID:26337276  


Genomics

Comparative Map Data
Abcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81079,793,571 - 79,839,528 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1079,793,583 - 79,839,494 (-)EnsemblGRCr8
mRatBN7.21079,296,681 - 79,342,749 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1083,901,889 - 83,947,612 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01083,400,010 - 83,445,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01078,914,311 - 78,960,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)Ensemblrn6Rnor6.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
ABCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,634,881 - 50,692,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,634,609 - 50,692,631 (+)Ensemblhg38GRCh38
GRCh371748,712,242 - 48,769,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,067,227 - 46,124,062 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341746,067,226 - 46,124,061NCBI
Celera1745,173,593 - 45,230,401 (+)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1744,080,218 - 44,136,477 (+)NCBIHuRef
CHM1_11748,776,209 - 48,833,053 (+)NCBICHM1_1
T2T-CHM13v2.01751,502,046 - 51,559,449 (+)NCBIT2T-CHM13v2.0
Abcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,234,121 - 94,283,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,234,121 - 94,283,823 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381194,343,295 - 94,393,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,343,295 - 94,392,997 (-)Ensemblmm10GRCm38
MGSCv371194,204,609 - 94,254,290 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361194,159,385 - 94,209,066 (-)NCBIMGSCv36mm8
Celera11103,962,067 - 104,011,589 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1158.9NCBI
Abcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,087,570 - 11,130,482 (-)Ensembl
ChiLan1.0NW_00495545111,087,246 - 11,130,108 (-)NCBIChiLan1.0ChiLan1.0
ABCC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,826,417 - 66,883,666 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,633,385 - 71,690,669 (+)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1749,603,268 - 49,659,318 (+)EnsemblpanPan2panpan1.1
ABCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl927,345,878 - 27,390,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,040,445 - 11,086,566 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,920,821 - 26,979,602 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11226,920,764 - 26,978,389 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,060,930 - 27,117,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,646,316 - 42,703,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1642,646,812 - 42,702,852 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607713,362,436 - 13,419,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,516,224 - 6,557,892 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247956,516,384 - 6,558,332 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1951,148,823 - 51,193,924 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcc3
1166 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:133
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000003977, ENSRNOT00000051497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH136767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,296,715 - 79,296,805 (+)MAPPERmRatBN7.2
Rnor_6.01082,047,331 - 82,047,420NCBIRnor6.0
Rnor_5.01081,879,510 - 81,879,599UniSTSRnor5.0
RGSC_v3.41082,986,575 - 82,986,664UniSTSRGSC3.4
Celera1078,085,522 - 78,085,611UniSTS
RH 3.4 Map10720.4UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 87 59 6 351 187 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY039030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003977   ⟹   ENSRNOP00000003977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,793,583 - 79,824,492 (-)Ensembl
mRatBN7.2 Ensembl1079,296,693 - 79,327,604 (-)Ensembl
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051497   ⟹   ENSRNOP00000041502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,793,583 - 79,824,492 (-)Ensembl
mRatBN7.2 Ensembl1079,296,693 - 79,327,604 (-)Ensembl
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079711   ⟹   ENSRNOP00000073075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,074,211 - 82,117,109 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085451   ⟹   ENSRNOP00000069018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,793,583 - 79,839,484 (-)Ensembl
mRatBN7.2 Ensembl1079,296,693 - 79,342,595 (-)Ensembl
Rnor_6.0 Ensembl1082,050,695 - 82,116,679 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149960   ⟹   ENSRNOP00000104971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,798,518 - 79,839,494 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160334   ⟹   ENSRNOP00000110987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1079,793,583 - 79,839,484 (-)Ensembl
RefSeq Acc Id: NM_080581   ⟹   NP_542148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,583 - 79,839,484 (-)NCBI
mRatBN7.21079,296,693 - 79,342,595 (-)NCBI
Rnor_6.01082,047,308 - 82,116,669 (-)NCBI
Rnor_5.01081,879,487 - 81,880,151 (-)NCBI
Rnor_5.01081,896,621 - 81,938,192 (-)NCBI
RGSC_v3.41082,986,552 - 83,030,799 (-)RGD
Celera1078,085,499 - 78,131,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596968   ⟹   XP_017452457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,561 - 79,342,748 (-)NCBI
Rnor_6.01082,083,094 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596970   ⟹   XP_017452459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,792 - 79,342,748 (-)NCBI
Rnor_6.01082,083,332 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596971   ⟹   XP_017452460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,787 - 79,342,748 (-)NCBI
Rnor_6.01082,083,314 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085087   ⟹   XP_038941015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,571 - 79,820,659 (-)NCBI
mRatBN7.21079,296,681 - 79,323,774 (-)NCBI
RefSeq Acc Id: XM_063268341   ⟹   XP_063124411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,793,571 - 79,822,897 (-)NCBI
RefSeq Acc Id: XR_001840004
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,803,037 - 79,839,528 (-)NCBI
mRatBN7.21079,306,149 - 79,342,748 (-)NCBI
Rnor_6.01082,078,648 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489679
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,916 - 79,342,749 (-)NCBI
RefSeq Acc Id: XR_005489680
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
mRatBN7.21079,310,889 - 79,342,748 (-)NCBI
RefSeq Acc Id: XR_010055119
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
RefSeq Acc Id: XR_010055120
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
RefSeq Acc Id: XR_010055121
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81079,807,717 - 79,839,528 (-)NCBI
RefSeq Acc Id: NP_542148   ⟸   NM_080581
- UniProtKB: O88563 (UniProtKB/Swiss-Prot),   O88270 (UniProtKB/Swiss-Prot),   A0A0G2JU97 (UniProtKB/TrEMBL),   A6HI45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452457   ⟸   XM_017596968
- Peptide Label: isoform X2
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452460   ⟸   XM_017596971
- Peptide Label: isoform X3
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452459   ⟸   XM_017596970
- Peptide Label: isoform X3
- UniProtKB: A6HI46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073075   ⟸   ENSRNOT00000079711
Ensembl Acc Id: ENSRNOP00000069018   ⟸   ENSRNOT00000085451
Ensembl Acc Id: ENSRNOP00000041502   ⟸   ENSRNOT00000051497
Ensembl Acc Id: ENSRNOP00000003977   ⟸   ENSRNOT00000003977
RefSeq Acc Id: XP_038941015   ⟸   XM_039085087
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124411   ⟸   XM_063268341
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000110987   ⟸   ENSRNOT00000160334
Ensembl Acc Id: ENSRNOP00000104971   ⟸   ENSRNOT00000149960
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88563-F1-model_v2 AlphaFold O88563 1-1522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697603
Promoter ID:EPDNEW_R8126
Type:initiation region
Name:Abcc3_1
Description:ATP binding cassette subfamily C member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,116,680 - 82,116,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71101 AgrOrtholog
BioCyc Gene G2FUF-23623 BioCyc
Ensembl Genes ENSRNOG00000002948 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085451 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  Multidrug-R_assoc UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  TMD0_ABC UniProtKB/Swiss-Prot
KEGG Report rno:140668 UniProtKB/Swiss-Prot
NCBI Gene 140668 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 3 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
  TMD0_ABC UniProtKB/Swiss-Prot
PharmGKB ABCC3 RGD
PhenoGen Abcc3 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002948 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A0G2JU97 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJ98_RAT UniProtKB/TrEMBL
  A0ABK0LZ61_RAT UniProtKB/TrEMBL
  A6HI45 ENTREZGENE, UniProtKB/TrEMBL
  A6HI46 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF64_RAT UniProtKB/TrEMBL
  F1LMJ7_RAT UniProtKB/TrEMBL
  MRP3_RAT UniProtKB/Swiss-Prot
  O88270 ENTREZGENE
  O88563 ENTREZGENE
UniProt Secondary O88270 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Abcc3  ATP binding cassette subfamily C member 3  Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may act as an inducible transporter in the biliary and intestinal excretion of organic anions 724707
gene_regulation upregulated in hepatocytes during liver regeneration after 90% but not after 70% partial hepatectomy 1304286