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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3decreases methylationISOABCC3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ABCC3 3' UTRPMID:27901495
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ABCC3 mRNAPMID:16545412 PMID:20106945 PMID:21632981 PMID:22316170
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ABCC3 mRNAPMID:32417428
Abcc3increases methylationISOABCC3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ABCC3 promoterPMID:27901495
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