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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCC3 mRNAPMID:33387578
Abcc3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCC3 mRNAPMID:21215274 PMID:32109520
Abcc3affects expressionISOAbcc3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ABCC3 mRNAPMID:18343893 PMID:20702594 PMID:21570461
Abcc3decreases expressionISOAbcc3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ABCC3 mRNAPMID:16120747
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCC3 mRNAPMID:19619570 PMID:20106945 PMID:21632981 PMID:25803276 PMID:27450509
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ABCC3 mRNAPMID:15833929 PMID:18796159 PMID:20005886 PMID:21095216 PMID:22496397 PMID:23994337 PMID:24713691
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC3 mRNAPMID:19619570
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTD[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC3 mRNA; [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of ABCC3 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCC3 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCC3 mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ABCC3 mRNA]PMID:15833929 PMID:17627975 PMID:17942748 PMID:22496397 PMID:28433925
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