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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3increases activityISOABCC3 (Homo sapiens)6480464CTDRifampin results in increased activity of ABCC3 proteinPMID:14570758
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDRifampin results in increased expression of ABCC3 mRNAPMID:14570758 PMID:16837569 PMID:19041851 PMID:20832446 PMID:27199754
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTD[Rifampin co-treated with ABCC2 gene mutant form] results in increased expression of ABCC3 protein; [Rifampin results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; Rifampin inhibits the reaction [Decitabine results in increased expression of ABCC3 mRNA]PMID:14570758 PMID:16952291 PMID:23137910
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