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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3increases expressionEXP 6480464CTDUrsodeoxycholic Acid results in increased expression of ABCC3 mRNAPMID:16764892
Abcc3multiple interactionsEXP 6480464CTDUrsodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 protein]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC3 promoter]PMID:18687751 PMID:25418378
Abcc3affects expressionISOAbcc3 (Mus musculus)6480464CTDUrsodeoxycholic Acid affects the expression of ABCC3 proteinPMID:16472600
Abcc3increases expressionISOABCC3 (Homo sapiens)6480464CTDUrsodeoxycholic Acid results in increased expression of ABCC3 mRNAPMID:25055961
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDUrsodeoxycholic Acid results in increased expression of ABCC3 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC3 proteinPMID:12971955 PMID:18687751 PMID:25582706
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTDNFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 protein]PMID:18687751
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