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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71101
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc3increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of ABCC3 mRNA; Ethinyl Estradiol results in increased expression of ABCC3 proteinPMID:16105132 PMID:16554369 PMID:17686906 PMID:23146761 PMID:27765674
Abcc3multiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC3 mRNA; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein; Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]PMID:16105132 PMID:16554369 PMID:17686906
Abcc3affects expressionISOAbcc3 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of ABCC3 mRNAPMID:17555576
Abcc3increases expressionISOAbcc3 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of ABCC3 mRNAPMID:17942748 PMID:27818225
Abcc3increases uptakeISOABCC3 (Homo sapiens)6480464CTDABCC3 protein results in increased uptake of Ethinyl Estradiol metabolitePMID:14722317
Abcc3multiple interactionsISOABCC3 (Homo sapiens)6480464CTDEthinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]PMID:14722317
Abcc3multiple interactionsISOAbcc3 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCC3 mRNAPMID:17942748
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