Bak1 (BCL2-antagonist/killer 1) - Rat Genome Database

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Gene: Bak1 (BCL2-antagonist/killer 1) Rattus norvegicus
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Symbol: Bak1
Name: BCL2-antagonist/killer 1
RGD ID: 621635
Description: Enables several functions, including heat shock protein binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in several processes, including positive regulation of release of cytochrome c from mitochondria; release of cytochrome c from mitochondria; and response to hydrogen peroxide. Located in cytoplasm. Biomarker of intermittent claudication. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1); PARTICIPATES IN intrinsic apoptotic pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bak; bcl-2 homologous antagonist/killer; MGC108627
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,102,334 - 5,111,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl205,102,335 - 5,110,974 (-)EnsemblGRCr8
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,826,258 - 5,834,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,188,000 - 5,196,555 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,666,112 - 5,674,701 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)Ensemblrn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,681,267 - 6,689,805 (-)NCBICelera
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-methoxy-17beta-estradiol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylthioamphetamine  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
alantolactone  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucan  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brusatol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (EXP,ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chrysophanol  (ISO)
cisplatin  (ISO)
coenzyme Q10  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
cucurbitacin B  (ISO)
curcumin  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP)
deguelin  (ISO)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dioscin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (EXP,ISO)
epichlorohydrin  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
farnesol  (ISO)
farrerol  (ISO)
fisetin  (ISO)
flavonoids  (ISO)
flufenamic acid  (ISO)
flufenoxuron  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gefitinib  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (EXP,ISO)
hyperforin  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
levamisole  (ISO)
LGK974  (ISO)
Licochalcone A  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
Luteolin 7-methyl ether  (EXP)
lycopene  (ISO)
Maduramicin  (ISO)
maneb  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
minocycline  (EXP)
Mitotane  (EXP)
MK-2206  (ISO)
morphine  (ISO)
mycophenolic acid  (ISO)
Myrtucommulone A  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
navitoclax  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
niclosamide  (ISO)
nimesulide  (EXP,ISO)
NORCANTHARIDIN  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
osthole  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perifosine  (ISO)
perillyl alcohol  (ISO)
PF-3758309  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinostrobin  (ISO)
platycodin D  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
promethazine  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulindac  (ISO)
sulindac sulfide  (EXP)
sulindac sulfone  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
taiwanin C  (ISO)
tamibarotene  (ISO)
TEMPO  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
trichostatin A  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
venetoclax  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
xanthohumol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
apoptotic process  (IEA,ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic signaling pathway  (IEA,ISO)
B cell apoptotic process  (ISO)
B cell homeostasis  (ISO)
B cell negative selection  (ISO)
blood vessel remodeling  (ISO)
cell population proliferation  (ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to UV  (IEA,ISO)
endocrine pancreas development  (IEP)
endoplasmic reticulum calcium ion homeostasis  (IEA)
establishment of localization in cell  (IEA)
establishment or maintenance of transmembrane electrochemical gradient  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
fibroblast apoptotic process  (ISO)
homeostasis of number of cells  (ISO)
intrinsic apoptotic signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
mitochondrial fusion  (ISO)
monoatomic ion transmembrane transport  (IEA)
myeloid cell homeostasis  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (NAS)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of proteolysis  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IMP,NAS)
post-embryonic camera-type eye morphogenesis  (ISO)
regulation of apoptotic process  (IEA)
regulation of cell cycle  (ISO)
regulation of mitochondrial membrane permeability  (IEA,ISO,ISS)
regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
regulation of transport  (IEA)
release of cytochrome c from mitochondria  (IEA,IMP,ISO,ISS)
response to ethanol  (IEP)
response to fungus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (IEP)
response to mycotoxin  (ISO)
response to UV-C  (IEP)
response to xenobiotic stimulus  (IEP)
thymocyte apoptotic process  (ISO)
vagina development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Bcl-2 apoptotic switch in cancer development and therapy. Adams JM and Cory S, Oncogene. 2007 Feb 26;26(9):1324-37.
2. Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans. Bowen JM, etal., Pathology. 2005 Feb;37(1):56-62.
3. Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: BAK- versus BAX-dependence. Brustovetsky N, etal., J Neurochem. 2003 Jan;84(1):196-207.
4. Tournefolic acid B attenuates amyloid beta protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons. Chi CW, etal., Eur J Pharmacol. 2008 May 31;586(1-3):35-43. Epub 2008 Feb 29.
5. Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chopra M, etal., Toxicol Sci. 2009 Sep;111(1):49-63. Epub 2009 Jun 10.
6. Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model. Dharmapuri S, etal., Hum Gene Ther. 2009 Jun;20(6):589-97.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition. Gavilan MP, etal., Aging Cell. 2009 Dec;8(6):654-65. Epub 2009 Sep 11.
9. Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release. Gillick K and Crompton M, J Cell Sci. 2008 Mar 1;121(Pt 5):618-26. Epub 2008 Feb 5.
10. Ethanol-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Placenta: Relevance to Pregnancy Loss. Gundogan F, etal., Alcohol Clin Exp Res. 2009 Dec 17.
11. Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Hanke J Anat Embryol (Berl). 2000 Oct;202(4):303-12.
12. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, etal., Proc Natl Acad Sci U S A 1997 Nov 11;94(23):12401-6.
13. BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia. Isaian A, etal., J Clin Immunol. 2010 Jan;30(1):132-7. doi: 10.1007/s10875-009-9340-6. Epub 2009 Nov 7.
14. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
15. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Kirchhoff SR, etal., Circulation. 2002 Jun 18;105(24):2899-904.
16. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura Y, etal., Brain Res. 1998 Jan 12;780(2):260-9.
17. Malignant transformation of normal enterocytes following downregulation of Bak expression. Liberman E, etal., Digestion. 2008;77(1):48-56. Epub 2008 Mar 18.
18. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
19. Pathways involved in testicular germ cell apoptosis induced by H2O2 in vitro. Maheshwari A, etal., FEBS J. 2009 Feb;276(3):870-81.
20. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Majewski N, etal., Mol Cell 2004 Dec 3;16(5):819-30.
21. Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore. Mandal T, etal., Sci Rep. 2016 Aug 4;6:30763. doi: 10.1038/srep30763.
22. Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats. Masson S, etal., Apoptosis. 2000 Apr;5(2):173-9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release. Mikhailov V, etal., J Biol Chem. 2003 Feb 14;278(7):5367-76. Epub 2002 Nov 25.
25. Right ventricular effects of intracoronary delivery of mesenchymal stem cells (MSC) in an animal model of pressure overload heart failure. Molina EJ, etal., Biomed Pharmacother. 2009 Dec;63(10):767-72. Epub 2008 Sep 25.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Expression of bcl-2, bcl-x, bax and bak in renal parenchyma, oncocytomas and renal cell carcinomas. Pammer J, etal., Pathol Res Pract. 1998;194(12):837-45.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. Reyes NA, etal., J Clin Invest. 2010 Oct;120(10):3673-9. doi: 10.1172/JCI42986. Epub 2010 Sep 20.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Differential expression of rat brain bcl-2 family proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):92-6.
33. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
34. p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
35. Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga KG, etal., Histol Histopathol. 2011 Jul;26(7):811-20. doi: 10.14670/HH-26.811.
36. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. Wang J, etal., J Biol Chem. 2004 May 7;279(19):19948-54. Epub 2004 Mar 5.
37. Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma. Wani KM, etal., Br J Cancer. 2003 May 19;88(10):1584-6.
38. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Wortham NC, etal., Fertil Steril. 2006 Oct;86(4):961-71. Epub 2006 Sep 7.
Additional References at PubMed
PMID:9111042   PMID:9176392   PMID:9843949   PMID:10579309   PMID:10837489   PMID:10950869   PMID:11146504   PMID:11163212   PMID:11836241   PMID:11850803   PMID:11980919   PMID:12142566  
PMID:12477932   PMID:12847083   PMID:15613488   PMID:15680329   PMID:15776018   PMID:15901672   PMID:15955981   PMID:15967824   PMID:16055554   PMID:16199525   PMID:16439990   PMID:16446153  
PMID:16893972   PMID:17024184   PMID:17035996   PMID:17068116   PMID:17289999   PMID:17446862   PMID:18387192   PMID:18414238   PMID:18614015   PMID:19593445   PMID:19862336   PMID:21041309  
PMID:22006182   PMID:23028632   PMID:23782464   PMID:25296756   PMID:26949185   PMID:29122578   PMID:29531808   PMID:35416269  


Genomics

Comparative Map Data
Bak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,102,334 - 5,111,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl205,102,335 - 5,110,974 (-)EnsemblGRCr8
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,826,258 - 5,834,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,188,000 - 5,196,555 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,666,112 - 5,674,701 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)Ensemblrn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,681,267 - 6,689,805 (-)NCBICelera
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Cytogenetic Map20p12NCBI
BAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,572,552 - 33,580,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,572,547 - 33,580,305 (-)Ensemblhg38GRCh38
GRCh37633,540,329 - 33,548,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
T2T-CHM13v2.0633,393,742 - 33,401,466 (-)NCBIT2T-CHM13v2.0
Bak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)Ensemblmm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBIMGSCv36mm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.65NCBI
Bak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,036,415 - 2,041,997 (-)Ensembl
ChiLan1.0NW_0049554372,036,415 - 2,041,997 (-)NCBIChiLan1.0ChiLan1.0
BAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,255,769 - 34,263,211 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)EnsemblpanPan2panpan1.1
BAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,950,359 - 2,957,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,948,364 - 2,957,018 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,967,686 - 2,970,924 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0123,282,315 - 3,289,076 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,280,333 - 3,289,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,950,651 - 2,953,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,031,622 - 3,034,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,129,752 - 3,132,990 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,808,849 - 29,815,318 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1729,808,849 - 29,815,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,279,191 - 34,286,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,492,776 - 38,502,534 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,492,858 - 38,501,281 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604433,412,290 - 33,419,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bak1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1186,780,175 - 6,788,702 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bak1
74 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:345
Count of miRNA genes:188
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000000576
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
D20Ztm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,106,468 - 5,106,627 (+)MAPPERmRatBN7.2
Rnor_6.0205,615,606 - 5,615,764NCBIRnor6.0
Rnor_5.0207,681,020 - 7,681,178UniSTSRnor5.0
RGSC_v3.4205,261,939 - 5,262,097UniSTSRGSC3.4
Celera206,687,154 - 6,687,312UniSTS
Cytogenetic Map20p12UniSTS
RH134024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,100,493 - 5,100,673 (+)MAPPERmRatBN7.2
Rnor_6.0205,609,634 - 5,609,813NCBIRnor6.0
Rnor_5.0207,675,075 - 7,675,254UniSTSRnor5.0
RGSC_v3.4205,255,967 - 5,256,146UniSTSRGSC3.4
Celera206,681,280 - 6,681,459UniSTS
RH 3.4 Map2055.83UniSTS
Cytogenetic Map20p12UniSTS
BE102269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,109,413 - 5,109,582 (+)MAPPERmRatBN7.2
Rnor_6.0205,618,551 - 5,618,719NCBIRnor6.0
Rnor_5.0207,683,965 - 7,684,133UniSTSRnor5.0
RGSC_v3.4205,264,884 - 5,265,052UniSTSRGSC3.4
Celera206,690,096 - 6,690,264UniSTS
RH 3.4 Map2054.8UniSTS
Cytogenetic Map20p12UniSTS
AW534505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,100,835 - 5,100,986 (+)MAPPERmRatBN7.2
Rnor_6.0205,609,976 - 5,610,126NCBIRnor6.0
Rnor_5.0207,675,417 - 7,675,567UniSTSRnor5.0
RGSC_v3.4205,256,309 - 5,256,459UniSTSRGSC3.4
Celera206,681,622 - 6,681,772UniSTS
RH 3.4 Map2056.0UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000576   ⟹   ENSRNOP00000000576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl205,102,335 - 5,110,974 (-)Ensembl
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)Ensembl
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092326   ⟹   ENSRNOP00000075913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,615,771 - 5,618,254 (-)Ensembl
RefSeq Acc Id: NM_053812   ⟹   NP_446264
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,102,335 - 5,110,974 (-)NCBI
mRatBN7.2205,100,481 - 5,109,123 (-)NCBI
Rnor_6.0205,609,621 - 5,618,260 (-)NCBI
Rnor_5.0207,675,062 - 7,683,731 (-)NCBI
RGSC_v3.4205,255,954 - 5,264,593 (-)RGD
Celera206,681,267 - 6,689,805 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256101   ⟹   XP_006256163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,102,334 - 5,111,615 (-)NCBI
mRatBN7.2205,100,480 - 5,109,669 (-)NCBI
Rnor_6.0205,609,620 - 5,618,899 (-)NCBI
Rnor_5.0207,675,062 - 7,683,731 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278930   ⟹   XP_063135000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,103,612 - 5,111,588 (-)NCBI
RefSeq Acc Id: NP_446264   ⟸   NM_053812
- UniProtKB: Q9JK59 (UniProtKB/TrEMBL),   A6JJK6 (UniProtKB/TrEMBL),   F7EQF3 (UniProtKB/TrEMBL),   Q5FVT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256163   ⟸   XM_006256101
- Peptide Label: isoform X1
- UniProtKB: Q9JK59 (UniProtKB/TrEMBL),   A6JJK6 (UniProtKB/TrEMBL),   F7EQF3 (UniProtKB/TrEMBL),   Q5FVT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075913   ⟸   ENSRNOT00000092326
Ensembl Acc Id: ENSRNOP00000000576   ⟸   ENSRNOT00000000576
RefSeq Acc Id: XP_063135000   ⟸   XM_063278930
- Peptide Label: isoform X2
Protein Domains
Bcl-2 Bcl-2 homology region 1-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JK59-F1-model_v2 AlphaFold Q9JK59 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701426
Promoter ID:EPDNEW_R11948
Type:initiation region
Name:Bak1_1
Description:BCL2-antagonist/killer 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,618,261 - 5,618,321EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621635 AgrOrtholog
BioCyc Gene G2FUF-4498 BioCyc
Ensembl Genes ENSRNOG00000000485 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000576 ENTREZGENE
  ENSRNOT00000000576.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366192 IMAGE-MGC_LOAD
InterPro Bcl-2_BH1-3 UniProtKB/TrEMBL
  BCL2_apoptsis UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/TrEMBL
  Blc2_fam UniProtKB/TrEMBL
KEGG Report rno:116502 UniProtKB/TrEMBL
MGC_CLONE MGC:108627 IMAGE-MGC_LOAD
NCBI Gene 116502 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF41 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
PharmGKB BAK1 RGD
PhenoGen Bak1 PhenoGen
PRINTS BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000485 RatGTEx
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt A6JJK5_RAT UniProtKB/TrEMBL
  A6JJK6 ENTREZGENE, UniProtKB/TrEMBL
  F7EQF3 ENTREZGENE
  Q5FVT4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JK59 ENTREZGENE
UniProt Secondary F7EQF3 UniProtKB/TrEMBL
  Q9JK59 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bak1  BCL2-antagonist/killer 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Bak1  BCL2-antagonist/killer 1      Symbol and Name status set to provisional 70820 PROVISIONAL