Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1affects expressionISOBAK1 (Homo sapiens)6480464CTDPaclitaxel affects the expression of BAK1 mRNA; Paclitaxel affects the expression of BAK1 proteinPMID:10822281
Bak1increases expressionISOBAK1 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of BAK1 mRNA; Paclitaxel results in increased expression of BAK1 proteinPMID:10822281 PMID:24126434
Bak1increases response to substanceISOBAK1 (Homo sapiens)6480464CTDBAK1 protein results in increased susceptibility to PaclitaxelPMID:17688235
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTD[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]PMID:17652622
Go Back to source page   Continue to Ontology report