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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1affects foldingISOBAK1 (Homo sapiens)6480464CTDresveratrol affects the folding of BAK1 proteinPMID:16617056
Bak1increases activityISOBAK1 (Homo sapiens)6480464CTDresveratrol results in increased activity of BAK1 proteinPMID:22245142 PMID:22644961
Bak1increases expressionISOBAK1 (Homo sapiens)6480464CTDresveratrol results in increased expression of BAK1 mRNA; resveratrol results in increased expression of BAK1 proteinPMID:12002526 PMID:12569576 PMID:16731767 PMID:17636462
Bak1increases response to substanceISOBAK1 (Homo sapiens)6480464CTDBAK1 protein results in increased susceptibility to resveratrolPMID:16550006 PMID:22245142
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTD[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [resveratrol results in increased localization of BAK1 protein]; BAK1 protein promotes the reaction [resveratrol results in increased secretion of AIFM1 protein]; BCL2L11 protein promotes the reaction [resveratrol results in increased activity of BAK1 protein]; CASP2 protein affects the reaction [resveratrol affects the folding of BAK1 protein]; resveratrol results in increased expression of and results in increased localization of BAK1 proteinPMID:12902349 PMID:16617056 PMID:22245142
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTDResveratrol results in increased expression of and results in increased localization of BAK1 proteinPMID:37482209
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