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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAK1 protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of BAK1 protein]PMID:22085843 PMID:28296042
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium results in increased expression of BAK1]PMID:23339468
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [arsenic trioxide results in increased expression of BAK1 mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of BAK1 mRNA]PMID:21533816 PMID:21549813
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