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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]PMID:19220725
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTD[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of BAK1 mRNA]PMID:10965999 PMID:33962019
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTDMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]PMID:23963992
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