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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1increases expressionISOBAK1 (Homo sapiens)6480464CTDBortezomib results in increased expression of BAK1 proteinPMID:17326159
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTD[nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein; BAK1 affects the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein]PMID:17326159 PMID:20850924
Bak1multiple interactionsISOBak1 (Mus musculus)6480464CTDBAK1 protein results in increased susceptibility to [Bortezomib co-treated with TNFSF10 protein]PMID:12902978
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