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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bak1
Name: BCL2-antagonist/killer 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bak1increases expressionISOBAK1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of BAK1; Fluorouracil results in increased expression of BAK1 mRNA; Fluorouracil results in increased expression of BAK1 proteinPMID:15489892 PMID:16557594 PMID:9792140
Bak1increases response to substanceISOBAK1 (Homo sapiens)6480464CTDBAK1 mRNA results in increased susceptibility to FluorouracilPMID:18593893
Bak1multiple interactionsISOBAK1 (Homo sapiens)6480464CTDmithramycin A inhibits the reaction [Fluorouracil results in increased expression of BAK1 protein]PMID:15489892
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