GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bak1 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of BAK1 mRNA; Doxorubicin results in increased expression of BAK1 protein | PMID:27087047 PMID:30009776 PMID:34713381 | Bak1 | multiple interactions | EXP | | 6480464 | CTD | coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of BAK1 protein] | PMID:27087047 | Bak1 | decreases expression | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of BAK1 mRNA | PMID:30581319 | Bak1 | decreases response to substance | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | BAK1 protein results in decreased susceptibility to Doxorubicin | PMID:11313874 | Bak1 | increases activity | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased activity of BAK1 protein | PMID:15917298 | Bak1 | increases expression | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of BAK1 mRNA; Doxorubicin results in increased expression of BAK1 protein | PMID:20856197 PMID:29803840 | Bak1 | increases expression | ISO | Bak1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of BAK1 mRNA; Doxorubicin results in increased expression of BAK1 protein | PMID:26873546 PMID:34713381 | Bak1 | increases response to substance | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | BAK1 protein results in increased susceptibility to Doxorubicin | PMID:17688235 | Bak1 | multiple interactions | ISO | BAK1 (Homo sapiens) | 6480464 | CTD | BAK1 protein results in increased susceptibility to [Doxorubicin co-treated with PI103]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]; Doxorubicin results in increased expression of and results in increased activity of BAK1 protein; Folic Acid inhibits the reaction [Doxorubicin results in decreased expression of BAK1 mRNA]; rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein] | PMID:15917298 PMID:20856197 PMID:30581319 | Bak1 | multiple interactions | ISO | Bak1 (Mus musculus) | 6480464 | CTD | [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BAK1 mRNA | PMID:26873546 | | ||||||||||||||||||||||
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