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Gene:
Pik3cb ( Rattus norvegicus )
phosphoinositide-3-kinase, catalytic, beta polypeptide
Description:may play a role in hepatocyte proliferation and DNA replication
Synonyms:phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 3-kinase, catalytic, beta polypeptide;  
ArrayIDs:5876712; GE1296104; 6200442; 6073600; A_44_P104679; rc_AI013876_at; 6681020; 6548567; 5949834; 6070470; 6274497; 5766852; 6065821; 1382174_at; 1387847_at; 6176659; 5919037; 6112641; 6076399; AJ012482_at; 6540126; 6730821; 6231172; 5719040; 6142903; 6074500; 5743536; 1383799_at; 5673772; 6131350; rc_AI227996_at; 6329560; A_43_P12820; 6068940; 5623850; 6577544; 5761669; 5762725; 5844421; 5986525; 6623609; 5774506; 6218476; 6671618; 6118565; 5713508; 6029603;  (details...)
Gene Type:protein-coding
 
Additional Data
 
Homologs
Homo sapiens: PIK3CB     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pik3cb     See the Mouse gene in context in:     UCSC     NCBI MapViewer
 
Comparative Map Data
SpeciesSymbolMap NameChr.Position
Rattus norvegicusPik3cbgenome assembly 3.18103906136 - 103976567
  Rat Celera Assembly899001715 - 99072100
  RGSC genome assembly v3.48103886682 - 103957112
  Cytogenetic8q31
Mus musculusPik3cbMouse genome assembly build 36.1998938821 - 99040506
  Cytogenetic99 E4
Homo sapiensPIK3CBhuman genome assembly3139856928 - 139960883
  Human genome assembly build 36.23139856921 - 139960875
  Cytogenetic3q22.3
 
View comparative maps:      NCBI MapViewer
 
 Genome
View:
 
Browsers:
 
 
 Annotation
Molecular Function
Gene Ontology
phosphoinositide 3-kinase activity,  nucleotide binding,  phosphatidylinositol-4,5-bisphosphate 3-kinase activity ...  (details...)
Biological Process
Gene Ontology
cellular calcium ion homeostasis,  platelet activation,  homophilic cell adhesion ...  (details...)
Cellular Component
Gene Ontology
phosphoinositide 3-kinase complex,  cytosol,  brush border membrane (details...)
Disease
Ontology
Thrombosis (details...)
Pathway
Ontology
inositol phosphate metabolic pathway,  phosphatidylinositol 3-kinase-Akt signaling pathway,  apoptotic cell death pathway (details...)
 
 External Links
Databases
DATABASEIDSOURCE
SMART:PI3KcIPI
SMART:PI3KaIPI
SMART:PI3K_rbdIPI
SMART:PI3K_p85BIPI
SMART:PI3K_C2IPI
PROSITE:PI3_4_KINASE_3IPI
PROSITE:PI3_4_KINASE_2IPI
PROSITE:PI3_4_KINASE_1IPI
UNIPARC:UPI0000130F9CIPI
KEGG Report:rno:85243ENTREZGENE
HomoloGene Group ID:21250ENTREZGENE
Germonline:620917
Pfam:PI3KaIPI
Pfam:PI3K_rbdIPI
Pfam:PI3K_p85BIPI
Pfam:PI3K_C2IPI
Pfam:PI3_PI4_kinaseIPI
KEGG Pathway:04150ENTREZGENE
KEGG Pathway:04370ENTREZGENE
KEGG Pathway:04930ENTREZGENE
KEGG Pathway:04620ENTREZGENE
KEGG Pathway:04660ENTREZGENE
KEGG Pathway:05222ENTREZGENE
KEGG Pathway:05211ENTREZGENE
KEGG Pathway:04810ENTREZGENE
KEGG Pathway:05215ENTREZGENE
KEGG Pathway:04070ENTREZGENE
KEGG Pathway:05200ENTREZGENE
KEGG Pathway:05212ENTREZGENE
KEGG Pathway:05223ENTREZGENE
KEGG Pathway:04722ENTREZGENE
KEGG Pathway:04650ENTREZGENE
KEGG Pathway:05218ENTREZGENE
KEGG Pathway:04670ENTREZGENE
KEGG Pathway:04630ENTREZGENE
KEGG Pathway:04910ENTREZGENE
KEGG Pathway:00562ENTREZGENE
KEGG Pathway:05214ENTREZGENE
KEGG Pathway:04510ENTREZGENE
KEGG Pathway:04666ENTREZGENE
KEGG Pathway:04664ENTREZGENE
KEGG Pathway:04012ENTREZGENE
KEGG Pathway:05213ENTREZGENE
KEGG Pathway:05210ENTREZGENE
KEGG Pathway:05220ENTREZGENE
KEGG Pathway:04062ENTREZGENE
KEGG Pathway:04662ENTREZGENE
KEGG Pathway:04210ENTREZGENE
KEGG Pathway:05221ENTREZGENE
InterPro:PI_Kinase.IPI
InterPro:PI3Ka.IPI
InterPro:PI3K_ras_bd.IPI
InterPro:PI3K_p85_bd.IPI
InterPro:PI3K_C2.IPI
InterPro:PI3/4_kinase_CS.IPI
InterPro:PI3/4_kinase_cat.IPI
InterPro:Kinase-like_dom.IPI
InterPro:C2_Ca/lipid-bd_reg_CaLB.IPI
InterPro:ARM-type_fold.IPI
IPI:IPI00208989IPI
Ensembl Protein:ENSRNOP00000022179IPI
Gene3D-CATH:PI3KaIPI
Gene3D-CATH:PI3/4_kinase_catIPI
Entrez Gene:Pik3cbENTREZGENE
UniProt:PK3CB_RATIPI
Ensembl Genes:ENSRNOG00000016384IPI
Superfamily-SCOP:Kinase_likeIPI
Superfamily-SCOP:C2_CaLBIPI
Superfamily-SCOP:ARM-type_foldIPI
PANTHER:PI_KinaseIPI
Sequences
Nucleotide:AJ012482Get FASTASearch GEO Profiles
Nucleotide:CH473954Get FASTASearch GEO Profiles
Nucleotide:NM_053481Get FASTASearch GEO Profiles
(View all 3 Nucleotide Accessions)
Protein:NP_445933Get FASTA
Protein:EDL77452Get FASTA
Protein:CAA10046Get FASTA
Protein:Q9Z1L0Get FASTA
(View all 4 Protein Accessions)
Clusters
UniGene:44268
 
 References
Curated References
11 references in RGD related to Pik3cb
Other References
5 other references at PubMed related to Pik3cb
 
 Database Information
RGD ID620917
History
Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference
09-SEP-08: Pik3cb phosphoinositide-3-kinase, catalytic, beta polypeptide Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863
14-DEC-04: Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide phosphatidylinositol 3-kinase, catalytic subunit, beta isoform APPROVED Name updated 1299863
07-AUG-02: Pik3cb phosphatidylinositol 3-kinase, catalytic subunit, beta isoform PROVISIONAL Symbol and Name status set to provisional 70820

       

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