Ep300 (EP300 lysine acetyltransferase) - Rat Genome Database

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Gene: Ep300 (EP300 lysine acetyltransferase) Rattus norvegicus
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Symbol: Ep300
Name: EP300 lysine acetyltransferase (Ensembl:E1A binding protein p300)
RGD ID: 620036
Description: Enables several functions, including DNA binding activity; DNA-binding transcription factor binding activity; and p53 binding activity. Involved in several processes, including cellular response to corticosteroid stimulus; positive regulation of cell differentiation; and regulation of primary metabolic process. Located in chromatin; cytoplasm; and nucleus. Part of protein-DNA complex. Used to study diabetic retinopathy; idiopathic pulmonary fibrosis; and membranoproliferative glomerulonephritis. Biomarker of several diseases, including alcohol use disorder; congenital diaphragmatic hernia; hepatocellular carcinoma; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E1A binding protein p300; histone acetyltransferase p300
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,987,857 - 115,058,652 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,946,982 - 115,058,574 (+)EnsemblGRCr8
mRatBN7.27113,108,476 - 113,178,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,106,247 - 113,178,529 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl7113,106,247 - 113,136,088 (+)EnsemblmRatBN7.2
Rnor_6.07122,818,194 - 122,889,055 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)Ensemblrn6Rnor6.0
Rnor_5.07122,792,742 - 122,863,551 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,938,507 - 120,008,886 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,426,729 - 109,497,522 (+)NCBICelera
RGSC_v3.17119,972,736 - 120,000,026 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
Agenesis of Corpus Callosum  (ISO)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
autosomal dominant cerebellar ataxia  (ISO)
Brain Hypoxia  (IEP)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (IEP)
cardiomyopathy  (ISO)
CHARGE syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (ISO)
Craniofacial Abnormalities  (ISO)
Desbuquois dysplasia  (ISO)
developmental and epileptic encephalopathy 18  (ISO)
Diabetic Nephropathies  (IDA,IEP)
diabetic retinopathy  (IMP)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endotoxemia  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP,IMP,ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (IEP)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP)
hereditary breast ovarian cancer syndrome  (ISO)
Hittner Hirsch Kreh Syndrome  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IMP)
hypertension  (IEP)
idiopathic pulmonary fibrosis  (IMP,ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (IEP)
lung adenocarcinoma  (ISO)
lung small cell carcinoma  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (IMP)
Menke-Hennekam Syndrome 2  (ISO)
microcephaly  (ISO)
Multicystic Dysplastic Kidney  (ISO)
Multiple Abnormalities  (ISO)
Nervous System Lead Poisoning  (IEP)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (IEP,ISO)
Painful Neuropathy  (IEP,IMP)
prostate cancer  (ISO)
Reperfusion Injury  (IDA,IEP)
Rubinstein-Taybi syndrome  (ISO)
Sepsis  (IEP)
Spinocerebellar Ataxias  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISS)
T-cell non-Hodgkin lymphoma  (ISO)
Thumb Deformity  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-aminobenzamide  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aconitine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (EXP)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
apocynin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CHIR 99021  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Crenigacestat  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP,ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
flavone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
galangin  (ISO)
gallic acid  (ISO)
Garcinol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kojic acid  (ISO)
KT 5720  (ISO)
lead(0)  (EXP)
LY294002  (EXP)
mechlorethamine  (EXP)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
miconazole  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
niclosamide  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
Panaxytriol  (ISO)
phenylephrine  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
prostaglandin E2  (ISO)
prostaglandin J2  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (EXP)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tamoxifen  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (EXP,ISO)
tungsten  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
apoptotic process  (ISO)
B cell differentiation  (ISO)
behavioral defense response  (ISO)
canonical NF-kappaB signal transduction  (ISO)
canonical Wnt signaling pathway  (ISO)
cellular response to antibiotic  (IEP)
cellular response to cAMP  (IEP)
cellular response to curcumin  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-1  (IMP)
cellular response to L-leucine  (ISO)
cellular response to mineralocorticoid stimulus  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nutrient levels  (ISO)
cellular response to retinoic acid  (IEP)
cellular response to trichostatin A  (IEP)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (IEP)
chromatin remodeling  (IEA,ISO)
circadian rhythm  (ISO)
digestive tract development  (IEP)
DNA repair-dependent chromatin remodeling  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (ISO)
heart development  (ISO)
host-mediated activation of viral transcription  (ISO)
internal peptidyl-lysine acetylation  (IMP,ISO)
internal protein amino acid acetylation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
learning or memory  (ISO)
lung development  (ISO)
megakaryocyte development  (ISO)
memory  (IEP)
multicellular organism growth  (ISO)
N-terminal peptidyl-lysine acetylation  (ISO)
negative regulation of apoptotic signaling pathway  (IMP)
negative regulation of autophagy  (ISO)
negative regulation of chromosome condensation  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of miRNA metabolic process  (IMP)
negative regulation of protein oligomerization  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
obsolete positive regulation of DNA-binding transcription factor activity  (IMP,ISO)
peptidyl-lysine acetylation  (IMP)
peptidyl-lysine butyrylation  (ISO)
peptidyl-lysine crotonylation  (ISO)
peptidyl-lysine propionylation  (ISO)
platelet formation  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of cell growth  (IMP)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of cell size  (IMP)
positive regulation of cellular response to hypoxia  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA binding  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (IDA,IMP,ISO)
positive regulation of glycoprotein biosynthetic process  (IMP)
positive regulation of hydrogen peroxide-mediated programmed cell death  (IMP)
positive regulation of muscle atrophy  (IMP)
positive regulation of neuron projection development  (ISO)
positive regulation of protein acetylation  (IMP)
positive regulation of protein import into nucleus  (IMP,ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein secretion  (IMP)
positive regulation of proteolysis  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of sarcomere organization  (IMP)
positive regulation of T-helper 17 cell lineage commitment  (ISO)
positive regulation of TORC1 signaling  (ISO)
positive regulation of TORC2 signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of translation  (IMP)
protein acetylation  (ISO)
protein destabilization  (ISO)
protein modification process  (IMP)
protein stabilization  (ISO)
protein-DNA complex assembly  (IDA)
regulation of androgen receptor signaling pathway  (ISO)
regulation of angiotensin metabolic process  (IDA)
regulation of DNA-templated transcription  (IEA)
regulation of glycolytic process  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tubulin deacetylation  (ISO)
response to calcium ion  (IMP)
response to cobalt ion  (IEP)
response to dexamethasone  (IMP)
response to estrogen  (IEP,ISO)
response to ethanol  (IEP)
response to fatty acid  (IEP)
response to glucose  (IMP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP,ISO)
response to retinoic acid  (IEP)
response to tumor necrosis factor  (IEP)
response to xenobiotic stimulus  (IMP)
rhythmic process  (IEA)
skeletal muscle tissue development  (ISO)
somitogenesis  (ISO)
swimming  (ISO)
thigmotaxis  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)

Cellular Component

Molecular Function
acetylation-dependent protein binding  (ISO)
acetyltransferase activity  (ISO)
acyltransferase activity  (IEA,ISO)
antigen binding  (IDA)
beta-catenin binding  (ISO)
bHLH transcription factor binding  (IPI)
chromatin binding  (IDA,ISO)
chromatin DNA binding  (IBA,IDA,ISO)
cis-regulatory region sequence-specific DNA binding  (IDA)
damaged DNA binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription factor binding  (IEA,IPI,ISO)
histone acetyltransferase activity  (IBA,IDA,IEA,ISO)
histone butyryltransferase activity  (ISO)
histone crotonyltransferase activity  (ISO)
histone H1K75 acetyltransferase activity  (ISO)
histone H2B acetyltransferase activity  (ISO)
histone H3 acetyltransferase activity  (ISO)
histone H3K122 acetyltransferase activity  (ISO)
histone H3K18 acetyltransferase activity  (ISO)
histone H3K27 acetyltransferase activity  (ISO)
histone H4 acetyltransferase activity  (ISO)
histone isonicotinyltransferase activity  (ISO)
histone lactyltransferase (CoA-dependent) activity  (ISO)
L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  (ISO)
metal ion binding  (IEA)
mitogen-activated protein kinase binding  (IPI)
NF-kappaB binding  (IPI,ISO)
nuclear androgen receptor binding  (ISO)
nuclear glucocorticoid receptor binding  (IDA)
nuclear receptor binding  (ISO)
p53 binding  (IPI,ISO)
peptide butyryltransferase activity  (ISO)
peroxisome proliferator activated receptor binding  (IDA)
pre-mRNA intronic binding  (ISO)
promoter-specific chromatin binding  (IDA)
protein antigen binding  (IPI)
protein binding  (IPI,ISO)
protein kinase binding  (IPI)
protein propionyltransferase activity  (ISO)
protein-containing complex binding  (IDA,IPI)
protein-lysine-acetyltransferase activity  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IDA)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
SMAD binding  (IPI)
STAT family protein binding  (ISO)
transcription coactivator activity  (IBA,IEA,ISO)
transcription coactivator binding  (ISO)
transcription coregulator activity  (IEA)
transcription coregulator binding  (IPI,ISO)
transcription factor binding  (IPI)
transferase activity  (IEA)
zinc ion binding  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle. Alamdari N, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Aug;299(2):R509-20. doi: 10.1152/ajpregu.00858.2009. Epub 2010 Jun 10.
2. SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription. Amat R, etal., J Biol Chem. 2007 Nov 23;282(47):34066-76. Epub 2007 Sep 20.
3. Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Andreassen OA, etal., Neurobiol Dis. 2002 Dec;11(3):410-24.
4. Recruitment of p300/CBP in p53-dependent signal pathways. Avantaggiati ML, etal., Cell. 1997 Jun 27;89(7):1175-84.
5. Histone acetyltransferase p300 modulates gene expression in an epigenetic manner at high blood alcohol levels. Bardag-Gorce F, etal., Exp Mol Pathol. 2007 Apr;82(2):197-202. Epub 2007 Jan 8.
6. Genetic heterogeneity in Rubinstein-Taybi syndrome: delineation of the phenotype of the first patients carrying mutations in EP300. Bartholdi D, etal., J Med Genet. 2007 May;44(5):327-33. Epub 2007 Jan 12.
7. Interaction between the HPV E7 oncoprotein and the transcriptional coactivator p300. Bernat A, etal., Oncogene. 2003 Sep 11;22(39):7871-81.
8. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
9. Adenovirus E1A inhibits cardiac myocyte-specific gene expression through its amino terminus. Bishopric NH, etal., J Biol Chem. 1997 Aug 15;272(33):20584-94.
10. Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy. Blind RD, etal., Biochem Biophys Res Commun. 2012 Apr 20;420(4):839-44. doi: 10.1016/j.bbrc.2012.03.084. Epub 2012 Mar 23.
11. Synchronous Recruitment of Epigenetic Modifiers to Endotoxin Synergistically Activated Tnf-alpha Gene in Acute Kidney Injury. Bomsztyk K, etal., PLoS One. 2013 Jul 30;8(7):e70322. doi: 10.1371/journal.pone.0070322. Print 2013.
12. Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. Bousiges O, etal., Neuropsychopharmacology. 2010 Dec;35(13):2521-37. doi: 10.1038/npp.2010.117. Epub 2010 Sep 1.
13. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Chamberlain W, etal., Biochem Cell Biol. 2012 Apr;90(2):200-8. doi: 10.1139/o11-082. Epub 2012 Jan 31.
14. Analysis of p53 and NF-kappaB signaling in modulating the cardiomyocyte fate during hypertrophy. Chatterjee A, etal., J Cell Physiol. 2011 Oct;226(10):2543-54. doi: 10.1002/jcp.22599.
15. Role of the transcriptional coactivator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle-stimulating hormone-mediated activation of the transferrin promoter in Sertoli cells. Chaudhary J and Skinner MK, Biol Reprod. 2001 Aug;65(2):568-74.
16. Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation. Chen YL, etal., Biochem Biophys Res Commun. 2010 May 28;396(2):294-8. doi: 10.1016/j.bbrc.2010.04.083. Epub 2010 Apr 23.
17. Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription. Chia DJ and Rotwein P, Mol Endocrinol. 2010 Oct;24(10):2038-49. Epub 2010 Aug 11.
18. PARP mediates structural alterations in diabetic cardiomyopathy. Chiu J, etal., J Mol Cell Cardiol. 2008 Sep;45(3):385-93. Epub 2008 Jul 8.
19. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Chiu J, etal., Nutrition. 2009 Mar 4.
20. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Chmelar R, etal., Int J Cancer. 2007 Feb 15;120(4):719-33.
21. The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Davidson SM, etal., Chembiochem. 2005 Jan;6(1):162-70.
22. p300 in prostate cancer proliferation and progression. Debes JD, etal., Cancer Res. 2003 Nov 15;63(22):7638-40.
23. Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. Dohda T, etal., J Biochem (Tokyo). 2004 Sep;136(3):313-9.
24. Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. Dohda T, etal., J Biochem. 2004 Sep;136(3):313-9.
25. miR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300. Duan Y, etal., Exp Cell Res. 2013 Feb 1;319(3):173-84. doi: 10.1016/j.yexcr.2012.11.015. Epub 2012 Dec 2.
26. Increased vascular permeability after cardiopulmonary bypass in patients with diabetes is associated with increased expression of vascular endothelial growth factor and hepatocyte growth factor. Emani S, etal., J Thorac Cardiovasc Surg. 2009 Jul;138(1):185-91. Epub 2009 Mar 13.
27. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Feng B, etal., Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15.
28. miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. Feng B, etal., Diabetes. 2011 Nov;60(11):2975-84. doi: 10.2337/db11-0478. Epub 2011 Sep 1.
29. The histone acetyltransferase p300 promotes intrinsic axonal regeneration. Gaub P, etal., Brain. 2011 Jul;134(Pt 7):2134-48. doi: 10.1093/brain/awr142.
30. HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation. Gaub P, etal., Cell Death Differ. 2010 Sep;17(9):1392-408. doi: 10.1038/cdd.2009.216. Epub 2010 Jan 22.
31. Expression and Prognostic Significance of EP300, TP53 and BAX in Clear Cell Renal Cell Carcinoma. Godlewski J, etal., Anticancer Res. 2017 Jun;37(6):2927-2937. doi: 10.21873/anticanres.11646.
32. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
33. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. Gusterson RJ, etal., J Biol Chem 2003 Feb 28;278(9):6838-47. Epub 2002 Dec 10.
34. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Haldar SM, etal., Sci Transl Med. 2010 Apr 7;2(26):26ra26. doi: 10.1126/scitranslmed.3000502.
35. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Hall JM and McDonnell DP, Mol Interv. 2005 Dec;5(6):343-57.
36. MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer. Hansson ML, etal., PLoS One. 2012;7(9):e46001. doi: 10.1371/journal.pone.0046001. Epub 2012 Sep 27.
37. Epigenetic Regulation of Genes that Modulate Chronic Stress-induced Visceral Pain in the Peripheral Nervous System. Hong S, etal., Gastroenterology. 2014 Sep 25. pii: S0016-5085(14)01186-X. doi: 10.1053/j.gastro.2014.09.032.
38. NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes. Hsieh HL, etal., J Neuroinflammation. 2012 Jul 6;9:110. doi: 10.1186/1742-2094-9-110.
39. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells. Hua P, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1418-29. doi: 10.1152/ajprenal.00477.2011. Epub 2012 Feb 22.
40. Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator. Hudelist G, etal., Breast Cancer Res Treat. 2003 Mar;78(2):193-204.
41. NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons. Hughes R, etal., Cell Death Differ. 2011 Jun;18(6):937-47. doi: 10.1038/cdd.2010.166. Epub 2010 Dec 17.
42. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. Ikeuchi Y, etal., J Neurosci. 2009 Apr 1;29(13):4312-21.
43. A novel tumor necrosis factor alpha-responsive CCAAT/enhancer binding protein site regulates expression of the cartilage-derived retinoic acid-sensitive protein gene in cartilage. Imamura T, etal., Arthritis Rheum. 2008 May;58(5):1366-76.
44. Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. Imamura T, etal., J Biol Chem. 2005 Apr 29;280(17):16625-34. Epub 2005 Feb 18.
45. Auto-acetylation stabilizes p300 in cardiac myocytes during acute oxidative stress, promoting STAT3 accumulation and cell survival. Jain S, etal., Breast Cancer Res Treat. 2012 Aug;135(1):103-14. doi: 10.1007/s10549-012-2069-6. Epub 2012 May 5.
46. Novel glucocorticoid receptor coactivator effector mechanisms. Jenkins BD, etal., Trends Endocrinol Metab. 2001 Apr;12(3):122-6.
47. alpha-Synuclein negatively regulates protein kinase Cdelta expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. Jin H, etal., J Neurosci. 2011 Feb 9;31(6):2035-51. doi: 10.1523/JNEUROSCI.5634-10.2011.
48. Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). Kadiyala CS, etal., J Biol Chem. 2012 Jul 27;287(31):25869-80. doi: 10.1074/jbc.M112.375204. Epub 2012 May 30.
49. Immunohistochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: correlation with renal injury. Kassimatis TI, etal., J Cell Mol Med. 2006 Oct-Dec;10(4):908-21.
50. TGF-beta induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy. Kato M, etal., Sci Signal. 2013 Jun 4;6(278):ra43. doi: 10.1126/scisignal.2003389.
51. Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300. Kaur H, etal., Diabetes. 2006 Nov;55(11):3104-11.
52. Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. Kawamura T, etal., Circ Res. 2004 Jun 11;94(11):1492-9. Epub 2004 Apr 29.
53. Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation. Kundumani-Sridharan V, etal., J Biol Chem. 2012 Jun 29;287(27):22463-82. doi: 10.1074/jbc.M112.362996. Epub 2012 May 6.
54. Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF. Lee M and Partridge NC, J Biol Chem. 2010 Dec 3;285(49):38014-22. doi: 10.1074/jbc.M110.142141. Epub 2010 Sep 24.
55. Curcumin prevents and reverses murine cardiac hypertrophy. Li HL, etal., J Clin Invest. 2008 Mar;118(3):879-93.
56. Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats. Li N, etal., Cell Death Dis. 2017 Feb 23;8(2):e2624. doi: 10.1038/cddis.2017.16.
57. Carboxyl terminus of Nkx2.5 impairs its interaction with p300. Li T, etal., J Mol Biol. 2007 Jul 27;370(5):976-92. Epub 2007 May 18.
58. p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen. Lill NL, etal., J Virol. 1997 Jan;71(1):129-37.
59. CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. Liu YZ, etal., Neuroreport. 1999 Apr 26;10(6):1239-43.
60. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
61. Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes. Long X, etal., Mol Cell Biochem. 2007 Sep;303(1-2):167-74. Epub 2007 Apr 25.
62. Epigenetic histone modification regulates developmental lead exposure induced hyperactivity in rats. Luo M, etal., Toxicol Lett. 2014 Feb 10;225(1):78-85. doi: 10.1016/j.toxlet.2013.11.025. Epub 2013 Dec 1.
63. NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction. Mandolesi G, etal., FEBS Lett. 2002 Jan 2;510(1-2):50-6.
64. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Marinova Z, etal., J Neurochem. 2009 Nov;111(4):976-87. Epub 2009 Sep 18.
65. Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Marinova Z, etal., Neuropharmacology. 2011 Jun;60(7-8):1109-15. doi: 10.1016/j.neuropharm.2010.09.022. Epub 2010 Oct 1.
66. Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. Melas PA, etal., Transl Psychiatry. 2013 May 7;3:e255. doi: 10.1038/tp.2013.31.
67. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
68. Fatty acids in component of milk enhance the expression of the cAMP-response-element-binding-protein-binding protein (CBP)/p300 gene in developing rats. Mochizuki K, etal., Br J Nutr. 2008 Mar;99(3):481-6. Epub 2007 Oct 5.
69. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Mochizuki K, etal., Gene 2002 May 29;291(1-2):271-7.
70. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. Morimoto T, etal., J Clin Invest. 2008 Mar;118(3):868-78.
71. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
72. Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase. Nie D, etal., Blood. 2000 Apr 1;95(7):2304-11.
73. Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Ohta K, etal., Biochem J. 2007 Mar 15;402(3):559-66.
74. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
75. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
76. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
77. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
78. Hepatocyte nuclear factor-1alpha mediated upregulation of albumin expression in focal ischemic rat brain. Prajapati KD, etal., Neurol Res. 2012 Jan;34(1):25-31. doi: 10.1179/1743132811Y.0000000052.
79. GOA pipeline RGD automated data pipeline
80. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
81. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
82. Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Roelfsema JH, etal., Am J Hum Genet. 2005 Apr;76(4):572-80. Epub 2005 Feb 10.
83. Cooperation of SRC-1 and p300 with NF-kappaB and CREB in angiotensin II-induced IL-6 expression in vascular smooth muscle cells. Sahar S, etal., Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1528-34. Epub 2007 May 10.
84. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
85. Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy. Sharma S, etal., EMBO Mol Med. 2012 Jul;4(7):617-32. doi: 10.1002/emmm.201200234. Epub 2012 Apr 24.
86. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. Sunagawa Y, etal., J Biol Chem. 2010 Mar 26;285(13):9556-68. doi: 10.1074/jbc.M109.070458. Epub 2010 Jan 17.
87. SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. Tai DJ, etal., J Biol Chem. 2009 Feb 13;284(7):4073-89. Epub 2008 Dec 16.
88. Downregulation of p300 gene expression in airway mesenchyme of nitrofen-induced hypoplastic lungs. Takahashi H, etal., Pediatr Surg Int. 2014 Apr;30(4):431-5. doi: 10.1007/s00383-014-3466-1.
89. p300 expression is induced by oxygen deficiency and protects neuron cells from damage. Tan XL, etal., Brain Res. 2009 Feb 13;1254:1-9. Epub 2008 Dec 10.
90. CoCl2-induced expression of p300 promotes neuronal-like PC12 cell damage. Tan XL, etal., Neurosci Lett. 2008 Aug 29;441(3):272-6. Epub 2008 Jun 22.
91. Basic fibroblast growth factor stimulates fibronectin expression through phospholipase C gamma, protein kinase C alpha, c-Src, NF-kappaB, and p300 pathway in osteoblasts. Tang CH, etal., J Cell Physiol. 2007 Apr;211(1):45-55.
92. Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo. Tao J, etal., Biomed Pharmacother. 2018 Oct;106:1727-1733. doi: 10.1016/j.biopha.2018.07.132. Epub 2018 Jul 30.
93. A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration. Tedeschi A, etal., Cell Death Differ. 2009 Apr;16(4):543-54. Epub 2008 Dec 5.
94. In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Torres L, etal., Free Radic Biol Med. 2009 Mar 13.
95. Frequent induction of mammary carcinomas following neu oncogene transfer into in situ mammary epithelial cells of susceptible and resistant rat strains. Wang B, etal., Cancer Res. 1991 Oct 15;51(20):5649-54.
96. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Wang C, etal., Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
97. Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. Wang D, etal., PLoS One. 2010 Mar 24;5(3):e9853.
98. Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300. Wei JQ, etal., Circulation. 2008 Aug 26;118(9):934-46. Epub 2008 Aug 12.
99. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Wong HK, etal., Hum Mol Genet. 2013 Aug 1;22(15):3077-92. doi: 10.1093/hmg/ddt164. Epub 2013 Apr 11.
100. IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes. Wu CY, etal., J Neurochem. 2008 May;105(4):1499-512. Epub 2008 Feb 27.
101. PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes. Xu B, etal., Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):404-12.
102. Cardiac p300 is involved in myocyte growth with decompensated heart failure. Yanazume T, etal., Mol Cell Biol. 2003 May;23(10):3593-606.
103. Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT dependent. Yang H, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R337-4. Epub 2006 Sep 14.
104. ATRA activates and PDGF-BB represses the SM22alpha promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. Yu K, etal., Cardiovasc Res. 2011 Jun 1;90(3):464-74. doi: 10.1093/cvr/cvr017. Epub 2011 Jan 20.
105. Involvement of p300/CBP and epigenetic histone acetylation in TGF-beta1-mediated gene transcription in mesangial cells. Yuan H, etal., Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F601-13. doi: 10.1152/ajprenal.00523.2012. Epub 2012 Dec 12.
106. Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells. Zakrzewska A, etal., J Neurochem. 2005 Sep;94(5):1288-96. Epub 2005 Jul 5.
107. Retinoids induce MMP-9 expression through RARalpha during mammary gland remodeling. Zaragoza R, etal., Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1140-8. Epub 2006 Dec 12.
108. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Zhang H, etal., Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.
109. Sublytic C5b-9 induces IL-6 and TGF-beta1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPbeta acetylation. Zhang J, etal., FASEB J. 2014 Mar;28(3):1511-25. doi: 10.1096/fj.13-242693. Epub 2013 Dec 16.
110. Kruppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs. Zhang R, etal., Acta Pharmacol Sin. 2010 Oct;31(10):1293-302. doi: 10.1038/aps.2010.96. Epub 2010 Aug 16.
111. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
112. p300-Mediated Histone Acetylation is Essential for the Regulation of GATA4 and MEF2C by BMP2 in H9c2 Cells. Zheng M, etal., Cardiovasc Toxicol. 2013 Apr 30.
113. p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI). Zhu XY, etal., Mol Pain. 2012 Nov 23;8:84. doi: 10.1186/1744-8069-8-84.
114. Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. Ziel KA, etal., FASEB J. 2004 Jun;18(9):986-8. Epub 2004 Apr 14.
Additional References at PubMed
PMID:8684459   PMID:9194565   PMID:9512516   PMID:9679056   PMID:9742083   PMID:9862959   PMID:9887100   PMID:10518217   PMID:10733570   PMID:10783242   PMID:10893273   PMID:11349124  
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PMID:14517256   PMID:14645221   PMID:15100295   PMID:15199055   PMID:15220332   PMID:15261140   PMID:15601870   PMID:15616592   PMID:15669015   PMID:15681609   PMID:15937931   PMID:15994095  
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PMID:30193097   PMID:32285378   PMID:39230047  


Genomics

Comparative Map Data
Ep300
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,987,857 - 115,058,652 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,946,982 - 115,058,574 (+)EnsemblGRCr8
mRatBN7.27113,108,476 - 113,178,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,106,247 - 113,178,529 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl7113,106,247 - 113,136,088 (+)EnsemblmRatBN7.2
Rnor_6.07122,818,194 - 122,889,055 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)Ensemblrn6Rnor6.0
Rnor_5.07122,792,742 - 122,863,551 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,938,507 - 120,008,886 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,426,729 - 109,497,522 (+)NCBICelera
RGSC_v3.17119,972,736 - 120,000,026 (+)NCBI
Cytogenetic Map7q34NCBI
EP300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,091,816 - 41,180,077 (+)Ensemblhg38GRCh38
GRCh372241,488,596 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
T2T-CHM13v2.02241,567,504 - 41,655,012 (+)NCBIT2T-CHM13v2.0
Ep300
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,470,329 - 81,536,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,469,552 - 81,536,278 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,586,209 - 81,652,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,585,351 - 81,652,077 (+)Ensemblmm10GRCm38
MGSCv371581,416,644 - 81,482,507 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,413,469 - 81,479,332 (+)NCBIMGSCv36mm8
Celera1583,704,343 - 83,770,860 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.16NCBI
Ep300
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,648,339 - 26,727,933 (+)Ensembl
ChiLan1.0NW_00495541326,647,553 - 26,727,875 (+)NCBIChiLan1.0ChiLan1.0
EP300
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,922,082 - 51,012,599 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,622,035 - 53,712,518 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,986,467 - 22,076,921 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,079,214 - 40,168,936 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,079,503 - 40,168,604 (+)EnsemblpanPan2panpan1.1
ZC3H7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,882,379 - 23,944,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,884,981 - 23,920,131 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1023,814,502 - 23,876,996 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01024,626,532 - 24,689,038 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,626,546 - 24,688,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,343,251 - 24,405,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,664,137 - 24,726,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,838,614 - 24,901,106 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ep300
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,686,568 - 7,767,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492696,960 - 778,138 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492696,982 - 778,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EP300
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,311,171 - 7,393,760 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,311,165 - 7,394,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,574,025 - 4,656,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EP300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,634,132 - 23,726,095 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,634,571 - 23,724,979 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045101,701,940 - 101,792,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ep300
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,334,176 - 251,404,863 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ep300
599 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:80
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000000206
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH143832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,107,607 - 113,107,737 (+)MAPPERmRatBN7.2
Rnor_6.07122,818,100 - 122,818,229NCBIRnor6.0
Rnor_5.07122,792,639 - 122,792,768UniSTSRnor5.0
RGSC_v3.47119,937,433 - 119,937,562UniSTSRGSC3.4
Celera7109,426,635 - 109,426,764UniSTS
Cytogenetic Map7q34UniSTS
RH136048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,177,993 - 113,178,190 (+)MAPPERmRatBN7.2
mRatBN7.2X37,350,149 - 37,350,347 (+)MAPPERmRatBN7.2
Rnor_6.0X40,190,816 - 40,191,013NCBIRnor6.0
Rnor_6.07122,888,520 - 122,888,716NCBIRnor6.0
Rnor_5.07122,863,016 - 122,863,212UniSTSRnor5.0
Rnor_5.0X40,501,078 - 40,501,275UniSTSRnor5.0
RGSC_v3.4X58,645,117 - 58,645,314UniSTSRGSC3.4
RGSC_v3.47120,008,351 - 120,008,547UniSTSRGSC3.4
Celera7109,496,987 - 109,497,183UniSTS
CeleraX37,978,882 - 37,979,079UniSTS
Cytogenetic Map7q34UniSTS
EP300_8165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,177,410 - 113,178,207 (+)MAPPERmRatBN7.2
Rnor_6.07122,887,937 - 122,888,733NCBIRnor6.0
Rnor_5.07122,862,433 - 122,863,229UniSTSRnor5.0
RGSC_v3.47120,007,768 - 120,008,564UniSTSRGSC3.4
Celera7109,496,404 - 109,497,200UniSTS
Cytogenetic Map7q34UniSTS
Ep300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,124,618 - 113,124,736 (+)MAPPERmRatBN7.2
Rnor_6.07122,835,114 - 122,835,231NCBIRnor6.0
Rnor_5.07122,809,653 - 122,809,770UniSTSRnor5.0
RGSC_v3.47119,954,447 - 119,954,564UniSTSRGSC3.4
Celera7109,443,641 - 109,443,758UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000000206   ⟹   ENSRNOP00000000206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,124,023 - 113,136,088 (+)Ensembl
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101270   ⟹   ENSRNOP00000090584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,106,247 - 113,135,971 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115202   ⟹   ENSRNOP00000081554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,946,982 - 115,058,574 (+)Ensembl
mRatBN7.2 Ensembl7113,106,247 - 113,178,529 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164011   ⟹   ENSRNOP00000099411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,988,410 - 115,057,993 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170104   ⟹   ENSRNOP00000098770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,988,410 - 115,057,993 (+)Ensembl
RefSeq Acc Id: XM_039080287   ⟹   XP_038936215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,987,857 - 115,058,652 (+)NCBI
mRatBN7.27113,108,476 - 113,178,529 (+)NCBI
RefSeq Acc Id: XM_063264683   ⟹   XP_063120753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,987,857 - 115,058,652 (+)NCBI
Ensembl Acc Id: ENSRNOP00000000206   ⟸   ENSRNOT00000000206
RefSeq Acc Id: XP_038936215   ⟸   XM_039080287
- Peptide Label: isoform X1
- UniProtKB: A6HT04 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090584   ⟸   ENSRNOT00000101270
Ensembl Acc Id: ENSRNOP00000081554   ⟸   ENSRNOT00000115202
RefSeq Acc Id: XP_063120753   ⟸   XM_063264683
- Peptide Label: isoform X2
- UniProtKB: A6HT04 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098770   ⟸   ENSRNOT00000170104
Ensembl Acc Id: ENSRNOP00000099411   ⟸   ENSRNOT00000164011
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC09-F1-model_v2 AlphaFold A0A0G2QC09 1-728 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620036 AgrOrtholog
BioCyc Gene G2FUF-32672 BioCyc
Ensembl Genes ENSRNOG00000000190 Ensembl
  ENSRNOG00000065659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115202.2 UniProtKB/TrEMBL
  ENSRNOT00000164011 ENTREZGENE
  ENSRNOT00000164011.1 UniProtKB/TrEMBL
  ENSRNOT00000170104.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1630.10 UniProtKB/TrEMBL
  1.10.246.20 UniProtKB/TrEMBL
  1.20.1020.10 UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/TrEMBL
  2.10.110.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303964 IMAGE-MGC_LOAD
InterPro Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  Histone_AcTrfase_Rtt109/CBP UniProtKB/TrEMBL
  KIX_dom UniProtKB/TrEMBL
  KIX_dom_sf UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/TrEMBL
  PHD_P300 UniProtKB/TrEMBL
  RING_CBP-p300 UniProtKB/TrEMBL
  RING_CBP-p300_sf UniProtKB/TrEMBL
  TAZ_dom_sf UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_TAZ UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
MGC_CLONE MGC:106005 IMAGE-MGC_LOAD
NCBI Gene 170915 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE P300 UniProtKB/TrEMBL
  PTHR13808 UniProtKB/TrEMBL
Pfam Bromodomain UniProtKB/TrEMBL
  Creb_binding UniProtKB/TrEMBL
  DUF902 UniProtKB/TrEMBL
  HAT_KAT11 UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  PF00569 UniProtKB/TrEMBL
  PHD_P300 UniProtKB/TrEMBL
  zf-TAZ UniProtKB/TrEMBL
PharmGKB EP300 RGD
PhenoGen Ep300 PhenoGen
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  ZF_TAZ UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000190 RatGTEx
  ENSRNOG00000065659 RatGTEx
SMART BROMO UniProtKB/TrEMBL
  KAT11 UniProtKB/TrEMBL
  ZnF_TAZ UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF47040 UniProtKB/TrEMBL
  SSF47370 UniProtKB/TrEMBL
  SSF57933 UniProtKB/TrEMBL
  SSF69125 UniProtKB/TrEMBL
UniProt A0A8I6G641_RAT UniProtKB/TrEMBL
  A0ABK0L552_RAT UniProtKB/TrEMBL
  A0ABK0LGW0_RAT UniProtKB/TrEMBL
  A6HT04 ENTREZGENE, UniProtKB/TrEMBL
  A6HT05_RAT UniProtKB/TrEMBL
  Q5RJS0_RAT UniProtKB/TrEMBL
  Q91XT0_RAT UniProtKB/TrEMBL
UniProt Secondary F1LPY5 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Ep300  EP300 lysine acetyltransferase  Ep300  E1A binding protein p300  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ep300  E1A binding protein p300      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ep300  E1A binding protein p300      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains cDNA has nuclear receptor interaction domain 632678
gene_expression mRNA expressed in small intertine and various other tissues 632678
gene_function interacts with PPAR alpha and delta during fatty acid metabolism 632678