Ep300 (E1A binding protein p300) - Rat Genome Database

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Gene: Ep300 (E1A binding protein p300) Chinchilla lanigera
Analyze
Symbol: Ep300
Name: E1A binding protein p300
RGD ID: 9046093
Description: ENCODES a protein that exhibits acetylation-dependent protein binding (ortholog); acetyltransferase activity (ortholog); acyltransferase activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); apoptotic process (ortholog); B cell differentiation (ortholog); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); adenylosuccinase lyase deficiency (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: histone acetyltransferase p300
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,648,339 - 26,727,933 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,647,553 - 26,727,875 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
adenylosuccinase lyase deficiency  (ISO)
Agenesis of Corpus Callosum  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
autosomal dominant cerebellar ataxia  (ISO)
Brain Hypoxia  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cardiac arrest  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
CHARGE syndrome  (ISO)
clear cell renal cell carcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
common variable immunodeficiency 4  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
Craniofacial Abnormalities  (ISO)
developmental and epileptic encephalopathy 18  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endotoxemia  (ISO)
esophageal carcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hittner Hirsch Kreh Syndrome  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
idiopathic pulmonary fibrosis  (ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Menke-Hennekam Syndrome 2  (ISO)
microcephaly  (ISO)
Multicystic Dysplastic Kidney  (ISO)
Multiple Abnormalities  (ISO)
nephronophthisis-like nephropathy 1  (ISO)
Nervous System Lead Poisoning  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Painful Neuropathy  (ISO)
prostate cancer  (ISO)
Reperfusion Injury  (ISO)
Rubinstein-Taybi syndrome  (ISO)
Sepsis  (ISO)
Spinocerebellar Ataxias  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Thumb Deformity  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
apoptotic process  (ISO)
B cell differentiation  (ISO)
behavioral defense response  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to antibiotic  (ISO)
cellular response to cAMP  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to L-leucine  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to trichostatin A  (ISO)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chromatin remodeling  (ISO)
circadian rhythm  (ISO)
digestive tract development  (ISO)
face morphogenesis  (ISO)
fat cell differentiation  (ISO)
heart development  (ISO)
internal peptidyl-lysine acetylation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
learning or memory  (ISO)
lung development  (ISO)
macrophage derived foam cell differentiation  (ISO)
megakaryocyte development  (ISO)
memory  (ISO)
multicellular organism growth  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of miRNA metabolic process  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
peptidyl-lysine acetylation  (ISO)
platelet formation  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cellular response to hypoxia  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of hydrogen peroxide-mediated programmed cell death  (ISO)
positive regulation of muscle atrophy  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein acetylation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of sarcomere organization  (ISO)
positive regulation of T-helper 17 cell lineage commitment  (ISO)
positive regulation of TORC1 signaling  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of translation  (ISO)
protein destabilization  (ISO)
protein modification process  (ISO)
protein stabilization  (ISO)
protein-DNA complex assembly  (ISO)
regulation of androgen receptor signaling pathway  (ISO)
regulation of angiotensin metabolic process  (ISO)
regulation of glycolytic process  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of tubulin deacetylation  (ISO)
response to calcium ion  (ISO)
response to cobalt ion  (ISO)
response to dexamethasone  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucose  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to retinoic acid  (ISO)
response to tumor necrosis factor  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (ISO)
somitogenesis  (ISO)
swimming  (ISO)
thigmotaxis  (ISO)
transcription by RNA polymerase II  (ISO)
transcription initiation-coupled chromatin remodeling  (ISO)

Cellular Component

Molecular Function
acetylation-dependent protein binding  (ISO)
acetyltransferase activity  (ISO)
acyltransferase activity  (ISO)
antigen binding  (ISO)
beta-catenin binding  (ISO)
bHLH transcription factor binding  (ISO)
chromatin binding  (ISO)
chromatin DNA binding  (ISO)
cis-regulatory region sequence-specific DNA binding  (ISO)
damaged DNA binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription factor binding  (ISO)
histone acetyltransferase activity  (ISO)
histone butyryltransferase activity  (ISO)
histone crotonyltransferase activity  (ISO)
histone H2B acetyltransferase activity  (ISO)
histone H3 acetyltransferase activity  (ISO)
histone H3K122 acetyltransferase activity  (ISO)
histone H3K18 acetyltransferase activity  (ISO)
histone H3K27 acetyltransferase activity  (ISO)
histone H4 acetyltransferase activity  (ISO)
histone lactyltransferase activity  (ISO)
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  (ISO)
mitogen-activated protein kinase binding  (ISO)
NF-kappaB binding  (ISO)
nuclear androgen receptor binding  (ISO)
nuclear glucocorticoid receptor binding  (ISO)
nuclear receptor binding  (ISO)
p53 binding  (ISO)
peptide butyryltransferase activity  (ISO)
peptide-lysine-N-acetyltransferase activity  (ISO)
peroxisome proliferator activated receptor binding  (ISO)
pre-mRNA intronic binding  (ISO)
promoter-specific chromatin binding  (ISO)
protein antigen binding  (ISO)
protein binding  (ISO)
protein kinase binding  (ISO)
protein propionyltransferase activity  (ISO)
protein-containing complex binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
SMAD binding  (ISO)
STAT family protein binding  (ISO)
transcription coactivator activity  (ISO)
transcription coactivator binding  (ISO)
transcription coregulator binding  (ISO)
transcription factor binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ep300
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,648,339 - 26,727,933 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,647,553 - 26,727,875 (+)NCBIChiLan1.0ChiLan1.0
EP300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,092,592 - 41,180,077 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,488,596 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBINCBI36Build 36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
T2T-CHM13v2.02241,567,504 - 41,655,012 (+)NCBIT2T-CHM13v2.0
Ep300
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,470,329 - 81,536,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,469,552 - 81,536,278 (+)EnsemblGRCm39 Ensembl
GRCm381581,586,209 - 81,652,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,585,351 - 81,652,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,416,644 - 81,482,507 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,413,469 - 81,479,332 (+)NCBIMGSCv36mm8
Celera1583,704,343 - 83,770,860 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.16NCBI
Ep300
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,987,857 - 115,058,652 (+)NCBIGRCr8
mRatBN7.27113,108,476 - 113,178,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,106,247 - 113,178,529 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7113,106,247 - 113,136,088 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07122,818,194 - 122,889,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,792,742 - 122,863,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,938,507 - 120,008,886 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,972,736 - 120,000,026 (+)NCBI
Celera7109,426,729 - 109,497,522 (+)NCBICelera
Cytogenetic Map7q34NCBI
EP300
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,922,082 - 51,012,599 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,622,035 - 53,712,518 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,986,467 - 22,076,921 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12240,079,214 - 40,168,936 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,079,503 - 40,168,604 (+)Ensemblpanpan1.1panPan2
ZC3H7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,882,379 - 23,944,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,884,981 - 23,920,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,814,502 - 23,876,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,626,532 - 24,689,038 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,626,546 - 24,688,967 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,343,251 - 24,405,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,664,137 - 24,726,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,838,614 - 24,901,106 (-)NCBIUU_Cfam_GSD_1.0
Ep300
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,686,568 - 7,767,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492696,960 - 778,138 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936492696,982 - 778,132 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EP300
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,311,171 - 7,393,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,311,165 - 7,394,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,574,025 - 4,656,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EP300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,634,132 - 23,726,095 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,634,571 - 23,724,979 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045101,701,940 - 101,792,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000024998   ⟹   ENSCLAP00000024758
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541326,648,339 - 26,727,933 (+)Ensembl
RefSeq Acc Id: XM_005379339   ⟹   XP_005379396
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541326,647,553 - 26,727,875 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005379396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024758
  ENSCLAP00000024758.1
Reference Protein Sequences
RefSeq Acc Id: XP_005379396   ⟸   XM_005379339
- UniProtKB: A0A8C2W6H6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000024758   ⟸   ENSCLAT00000024998
Protein Domains
Bromo   CBP/p300-type HAT   KIX   TAZ-type   ZZ-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024998 ENTREZGENE
  ENSCLAT00000024998.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1630.10 UniProtKB/TrEMBL
  1.10.246.20 UniProtKB/TrEMBL
  1.20.1020.10 UniProtKB/TrEMBL
  1.20.920.10 UniProtKB/TrEMBL
  2.10.110.40 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
InterPro Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  Histone_AcTrfase_Rtt109/CBP UniProtKB/TrEMBL
  KIX_dom UniProtKB/TrEMBL
  KIX_dom_sf UniProtKB/TrEMBL
  Nuc_rcpt_coact UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp UniProtKB/TrEMBL
  Nuc_rcpt_coact_CREBbp_sf UniProtKB/TrEMBL
  RING_CBP-p300 UniProtKB/TrEMBL
  RING_CBP-p300_sf UniProtKB/TrEMBL
  TAZ_dom_sf UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_TAZ UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
NCBI Gene Ep300 ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE P300 UniProtKB/TrEMBL
  PTHR13808 UniProtKB/TrEMBL
Pfam Bromodomain UniProtKB/TrEMBL
  Creb_binding UniProtKB/TrEMBL
  DUF902 UniProtKB/TrEMBL
  HAT_KAT11 UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  PF00569 UniProtKB/TrEMBL
  zf-TAZ UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
  PRICHEXTENSN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  CBP_P300_HAT UniProtKB/TrEMBL
  KIX UniProtKB/TrEMBL
  ZF_TAZ UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
  KAT11 UniProtKB/TrEMBL
  ZnF_TAZ UniProtKB/TrEMBL
  ZnF_ZZ UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
  SSF47040 UniProtKB/TrEMBL
  SSF47370 UniProtKB/TrEMBL
  SSF57933 UniProtKB/TrEMBL
  SSF69125 UniProtKB/TrEMBL
UniProt A0A8C2W6H6 ENTREZGENE, UniProtKB/TrEMBL