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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620036
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ep300
Name: E1A binding protein p300
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ep300multiple interactionsISOEP300 (Homo sapiens)6480464CTD[Vorinostat co-treated with Quercetin] results in increased expression of EP300 protein; EP300 protein affects the reaction [[Vorinostat co-treated with Quercetin] results in increased expression of TNFRSF10B protein]; EP300 protein affects the reaction [Quercetin promotes the reaction [Vorinostat results in increased activity of CASP10 protein]]; EP300 protein affects the reaction [Quercetin promotes the reaction [Vorinostat results in increased activity of CASP3 protein]]; EP300 protein affects the reaction [Vorinostat results in increased activity of CASP10 protein]; EP300 protein affects the reaction [Vorinostat results in increased activity of CASP3 protein]; Vorinostat promotes the reaction [EP300 protein binds to RELA protein]PMID:20421217 PMID:30958996
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