Gene:	Nfkbia ( Rattus norvegicus ) nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Description:	inhibitor of NF-kappa-B; binds NF kappa B and retains it in the cytoplasm
Synonyms:	"inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha"; RL/IF-1; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha;  (details...)
ArrayIDs:	1389538_at; X63594cds_at; rc_AA801189_at; X63594cds_g_at; rc_AI172447_at;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: NFKBIA     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Nfkbia     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Nfkbia genome assembly 3.1 6 75732430 - 75735531     Rat Celera Assembly 6 71699196 - 71702378     RGSC genome assembly v3.4 6 75729302 - 75732442     Cytogenetic 6 q23 Mus musculus Nfkbia Mouse genome assembly build 36.1 12 56590831 - 56593570     Cytogenetic 12 12 C1-C3 Homo sapiens NFKBIA human genome assembly 14 34940467 - 34943695     Human genome assembly build 36.2 14 34940468 - 34943695     Cytogenetic 14 q13   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology NF-kappaB binding,  ubiquitin protein ligase binding,  protein complex binding ...  (details...)
Biological Process	Gene Ontology response to muramyl dipeptide,  cytoplasmic sequestering of NF-kappaB,  response to lipopolysaccharide ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  cytoplasm ...  (details...)
Disease	Ontology Hodgkin Disease,  Melanoma,  Lymphoma, Large-Cell, Diffuse ...  (details...)
Pathway	Ontology nuclear factor kappa B signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: ANK IPI PROSITE: ANK_REPEAT IPI PROSITE: ANK_REP_REGION IPI UNIPARC: UPI000004F0F7 IPI KEGG Report: rno:25493 ENTREZGENE HomoloGene Group ID: 7863 ENTREZGENE Germonline: 3171 Pfam: Ank IPI KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE KEGG Pathway: 04622 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE InterPro: Ankyrin_rpt-contain_dom. IPI InterPro: Ankyrin_rpt. IPI InterPro: NF_kB_inhbitor. IPI Ensembl Protein: ENSRNOP00000009894 IPI IPI: IPI00211841 IPI Gene3D-CATH: ANK IPI Entrez Gene: Nfkbia ENTREZGENE IMAGE_CLONE: IMAGE:6890357 IMAGE-MGC_LOAD MGC_CLONE: MGC:188827 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000007390 IPI UniProt: IKBA_RAT IPI UniProt: B2RYS5_RAT IPI RatMap: 41378 ENTREZGENE Superfamily-SCOP: ANK IPI PANTHER: NF_kB_inhbitor IPI
Sequences	Nucleotide: NM_001105720 Get FASTA Search GEO Profiles Nucleotide: XM_343065 Get FASTA Search GEO Profiles Nucleotide: CB793714 Get FASTA Search GEO Profiles Nucleotide: XM_001075778 Get FASTA Search GEO Profiles Nucleotide: CB324027 Get FASTA Search GEO Profiles Nucleotide: X63594 Get FASTA Search GEO Profiles Nucleotide: CB316505 Get FASTA Search GEO Profiles Nucleotide: CH473947 Get FASTA Search GEO Profiles Nucleotide: CA509173 Get FASTA Search GEO Profiles Nucleotide: BF417507 Get FASTA Search GEO Profiles Nucleotide: BC166886 Get FASTA Search GEO Profiles (View all 11 Nucleotide Accessions) Protein: XP_001075778 Get FASTA Protein: XP_343066 Get FASTA Protein: AAI66886 Get FASTA Protein: Q63746 Get FASTA Protein: NP_001099190 Get FASTA Protein: EDM03427 Get FASTA Protein: EDM03428 Get FASTA Protein: CAA45138 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 12550
References
Curated References	20 references in RGD related to Nfkbia
Other References	24 other references at PubMed related to Nfkbia
Database Information
RGD ID	3171
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 25-APR-08: Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Nfkbia nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 23-JUL-01: Nfkbia Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha WITHDRAWN Name withdrawn 67952