Nfkbia (NFKB inhibitor alpha) - Rat Genome Database

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Gene: Nfkbia (NFKB inhibitor alpha) Rattus norvegicus
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Symbol: Nfkbia
Name: NFKB inhibitor alpha
RGD ID: 3171
Description: Enables NF-kappaB binding activity and heat shock protein binding activity. Involved in liver regeneration; response to ethanol; and response to stress. Acts upstream of or within cellular response to cytokine stimulus. Located in cytosol. Part of protein-containing complex. Used to study gastritis; pulmonary emphysema; and sciatic neuropathy. Biomarker of several diseases, including acute necrotizing pancreatitis; alcoholic hepatitis; artery disease (multiple); middle cerebral artery infarction; and toxic shock syndrome. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-Tetrandrine; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: I-kappa-B-alpha; ikappaBalpha; ikB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; NF-kappa-B inhibitor alpha; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; RL/IF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,593,844 - 78,597,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,593,847 - 78,597,072 (-)EnsemblGRCr8
mRatBN7.2672,858,713 - 72,861,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx673,278,856 - 73,282,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,585,214 - 73,588,443 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,013,851 - 73,017,079 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,267,227 - 76,270,457 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)Ensemblrn6Rnor6.0
Rnor_5.0685,803,990 - 85,807,223 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,729,302 - 75,732,475 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,699,196 - 71,702,411 (-)NCBICelera
RGSC_v3.1675,732,430 - 75,735,531 (-)NCBI
Cytogenetic Map6q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (IEP)
Adenoviridae Infections  (ISO)
alcoholic hepatitis  (IEP)
arteriosclerosis  (ISO)
atopic dermatitis  (ISS)
Binge Drinking  (IEP)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Fibrosis  (IEP)
Cerebral Hemorrhage  (IDA)
childhood-onset asthma  (ISO)
Chronic Hepatitis B  (ISO)
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis  (ISO)
COVID-19  (ISO)
cryptorchidism  (ISO)
Cytomegalovirus Infections  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
ectodermal dysplasia and immunodeficiency 2  (ISO)
encephalitis  (IEP)
endometriosis  (IEP)
Endotoxemia  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (ISO)
gastritis  (IDA)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (IEP)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (IEP)
Intestinal Reperfusion Injury  (IEP)
Liver Reperfusion Injury  (IEP)
lung cancer  (ISO)
Lung Injury  (IEP)
melanoma  (ISO)
middle cerebral artery infarction  (IEP)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
pancreatic cancer  (ISO)
Pneumococcal Infections  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (IEP)
Pregnancy Complications  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (IDA)
pulmonary tuberculosis  (ISO)
Sarcopenia  (IEP)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
Sjogren's syndrome  (ISO,ISS)
Spinal Cord Injuries  (IEP)
stress-related disorder  (IEP)
toxic shock syndrome  (IEP)
toxoplasmosis  (ISO)
Transplant Rejection  (IEP,ISO)
vasculitis  (ISO)
Ventilator-Induced Lung Injury  (IEP)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-Erythraline  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Tetrandrine  (EXP)
(-)-acanthoic acid  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(20S)-ginsenoside Rh2  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (ISO)
1,8-cineole  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-bromopropane  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-4-trifluoromethyl benzoic acid  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-aminobenzamide  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methylcatechol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzohydrazide  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (EXP)
[6]-Shogaol  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (ISO)
albuterol  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
allyl methyl disulfide  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
Alternaramide  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP,ISO)
Ammothamnine  (ISO)
amorolfine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (ISO)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
ANTIMYCIN  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
Apicularen A  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (EXP)
aprepitant  (ISO)
Arctiin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arjunolic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asarone  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
ATP  (EXP,ISO)
Atractylodin  (ISO)
atrazine  (ISO)
auranofin  (ISO)
aureusidin  (ISO)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
baicalin  (EXP)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Berbamine  (ISO)
berberine  (ISO)
Bergenin  (EXP,ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-Elemonic acid  (ISO)
beta-endorphin  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-patchoulene  (EXP)
betulinic acid  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromoacetate  (ISO)
butenafine  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsiate  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carfilzomib  (EXP)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (EXP)
Carnosol  (ISO)
carrageenan  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
casticin  (ISO)
catechol  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
chalcone  (ISO)
chelerythrine  (ISO)
Chikusetsusaponin-IV  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholic acid  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
citronellol  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
corynoline  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cryptotanshinone  (ISO)
cudraflavone B  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (ISO)
daidzein  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP,ISO)
Decursin  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
Dehydrodiisoeugenol  (ISO)
demethoxycurcumin  (ISO)
DENSPM  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diallyl disulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (EXP,ISO)
diiodine  (EXP)
dimemorfan  (ISO)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (ISO)
diquat  (EXP)
disulfiram  (EXP,ISO)
dizocilpine maleate  (EXP)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental carbon  (ISO)
elemental selenium  (ISO)
emamectin benzoate  (ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
equol  (ISO)
erianin  (ISO)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
escitalopram  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
eupatilin  (ISO)
Evodiamine  (ISO)
Fargesin  (ISO)
fasudil  (EXP,ISO)
febuxostat  (EXP)
fenofibrate  (ISO)
fentanyl  (EXP,ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
fisetin  (EXP)
Flavokawain A  (ISO)
flavokawain B  (ISO)
flavone  (ISO)
fluoxetine  (EXP,ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formic acid  (ISO)
formononetin  (ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumaric acid  (ISO)
furan  (EXP,ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
gardenoside  (EXP)
Gastrodin  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Geraniin  (ISO)
geraniol  (EXP,ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
Ginkgolide C  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (EXP)
glycine  (ISO)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
guggulsterone  (EXP,ISO)
halothane  (EXP)
helenalin  (ISO)
heme b  (ISO)
herbimycin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (EXP,ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxyurea  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-butyric acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
ionomycin  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
isoeugenol  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isorhapontigenin  (EXP)
isothiocyanate  (ISO)
isovitexin  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
KN-93  (EXP)
kojic acid  (EXP)
KT 5823  (ISO)
kuwanone G  (ISO)
kynurenic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-365260  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-proline betaine  (ISO)
lactacystin  (ISO)
lansoprazole  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
leflunomide  (ISO)
Leonurine  (EXP,ISO)
levofloxacin  (EXP,ISO)
Licochalcone B  (ISO)
linderalactone  (ISO)
lipoarabinomannan  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lixisenatide  (ISO)
lonafarnib  (ISO)
loperamide  (ISO)
Lucidone  (ISO)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Macrosphelide B  (ISO)
Magnolol  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
meloxicam  (ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
Methyl palmitate  (ISO)
methylisothiazolinone  (ISO)
methyllycaconitine  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monotropein  (ISO)
morphine  (EXP,ISO)
muramyl dipeptide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylacetamide  (ISO)
N,N-dimethylformamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
Narciclasine  (ISO)
naringin  (ISO)
nectandrin B  (ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neohesperidin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (EXP)
nilotinib  (EXP)
nitric oxide  (ISO)
nitrogen mustard  (ISO)
nitroprusside  (ISO)
nonane  (EXP)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
o-anisidine  (ISO)
o-xylene  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP)
oroxylin A  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patchouli alcohol  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Pervanadate  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picolinic acid  (EXP)
pifithrin-alpha hydrobromide  (EXP)
piperine  (ISO)
pipoxolan  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
Praeruptorin A  (ISO)
prasugrel hydrochloride  (EXP)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (EXP)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
protosappanin A  (EXP)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercitrin  (EXP)
quinomethionate  (ISO)
quizartinib  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
Rebamipide  (EXP)
rebaudioside A  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhynchophylline  (EXP)
rimexolone  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rubiadin  (EXP)
rubimaillin  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
Sanggenon C  (ISO)
sappanchalcone  (ISO)
SB 203580  (EXP,ISO)
SCH 23390  (EXP)
scoparone  (ISO)
selenium atom  (ISO)
semaglutide  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
shikimic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sincalide  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SM-164  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sodium nitrite  (EXP)
sodium propionate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
Sophocarpine  (ISO)
Sophoricoside  (ISO)
sorafenib  (ISO)
soyasaponin I  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
synephrine  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP,ISO)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (EXP)
terbinafine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thiopental  (ISO)
thiram  (ISO)
Timosaponin b ii  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (EXP)
trans-anethole  (ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
trelagliptin  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trilobatin  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
Tylophorine  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (EXP)
undecan-2-one  (EXP,ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP,ISO)
venom  (ISO)
vildagliptin  (ISO)
vincaleukoblastine  (ISO)
vincamine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Vitisin A  (ISO)
vorinostat  (ISO)
wedelolactone  (EXP,ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
Xanthorrhizol  (ISO)
Y-27632  (EXP,ISO)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (ISO)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to cytokine stimulus  (IDA,IEA)
cellular response to tumor necrosis factor  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
liver regeneration  (IEP)
negative regulation of canonical NF-kappaB signal transduction  (IBA,ISO)
negative regulation of cholesterol transport  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
non-canonical NF-kappaB signal transduction  (ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
protein import into nucleus  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to ethanol  (IEP)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to muramyl dipeptide  (ISO)
response to muscle stretch  (ISO)
response to stress  (IEP)
toll-like receptor 4 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IDA,IEA,ISO)
I-kappaB/NF-kappaB complex  (ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
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2. Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia. Ali S, etal., J Immunol. 2013 Apr 15;190(8):3949-58. doi: 10.4049/jimmunol.1201015. Epub 2013 Mar 13.
3. Nuclear factor-kappaB as a target of cyclosporin in acute hypovolemic hemorrhagic shock. Altavilla D, etal., Cardiovasc Res. 2001 Oct;52(1):143-52. doi: 10.1016/s0008-6363(01)00362-5.
4. Selective up-regulation of I kappaB-alpha in ischemic penumbra following focal cerebral ischemia. Aronowski J, etal., Neuroreport. 2000 May 15;11(7):1529-33.
5. Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos. Birt JA, etal., Fertil Steril. 2013 Nov;100(5):1436-43. doi: 10.1016/j.fertnstert.2013.07.007. Epub 2013 Aug 15.
6. Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients. Bu H, etal., J Cancer Res Clin Oncol. 2007 Nov;133(11):859-66. Epub 2007 May 11.
7. Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Cabannes E, etal., Oncogene. 1999 May 20;18(20):3063-70.
8. IkappaB genetic polymorphisms and invasive pneumococcal disease. Chapman SJ, etal., Am J Respir Crit Care Med. 2007 Jul 15;176(2):181-7. doi: 10.1164/rccm.200702-169OC. Epub 2007 Apr 26.
9. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Chen HW, etal., Shock. 2005 Sep;24(3):232-8.
10. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Chen J, etal., Hum Reprod. 2012 Sep;27(9):2585-97. doi: 10.1093/humrep/des254. Epub 2012 Jul 9.
11. Association between polymorphisms in selected inflammatory response genes and the risk of prostate cancer. Chen J, etal., Onco Targets Ther. 2016 Jan 11;9:223-9. doi: 10.2147/OTT.S91420. eCollection 2016.
12. Effects of dihydroxylphenyl lactic acid on inflammatory responses in spinal cord injury. Chen X, etal., Brain Res. 2011 Feb 4;1372:160-8. doi: 10.1016/j.brainres.2010.11.089. Epub 2010 Dec 4.
13. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
14. Activation of the ubiquitin proteolytic system in murine acquired immunodeficiency syndrome affects IkappaBalpha turnover. Crinelli R, etal., Eur J Biochem. 1999 Jul;263(1):202-11. doi: 10.1046/j.1432-1327.1999.00485.x.
15. A multifactorial analysis of the pregnancy outcomes in cytomegalovirus-infected women. Ding ZY, etal., Gynecol Obstet Invest. 2015;80(2):106-12. doi: 10.1159/000370333. Epub 2015 Mar 19.
16. Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes. Doremus-Fitzwater TL, etal., Brain Behav Immun. 2018 May;70:141-156. doi: 10.1016/j.bbi.2018.02.009. Epub 2018 Feb 17.
17. Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells. Emmerich F, etal., Blood. 1999 Nov 1;94(9):3129-34.
18. Genetic variation on the NFKB1 genes associates with the outcomes of HCV infection among Chinese Han population. Fan HZ, etal., Infect Genet Evol. 2018 Nov;65:210-215. doi: 10.1016/j.meegid.2018.07.031. Epub 2018 Jul 26.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. IkappaB-alpha expression following transient focal cerebral ischemia is modulated by nitric oxide. Greco R, etal., Brain Res. 2011 Feb 4;1372:145-51. doi: 10.1016/j.brainres.2010.11.071. Epub 2010 Nov 28.
22. Glucocorticoids prevent NF-kappaB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide. Han SJ, etal., Eur J Immunol. 1999 Apr;29(4):1334-41. doi: 10.1002/(SICI)1521-4141(199904)29:04<1334::AID-IMMU1334>3.0.CO;2-0.
23. Myeloid cells control termination of lung inflammation through the NF-kappaB pathway. Han W, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L320-7. doi: 10.1152/ajplung.90485.2008. Epub 2008 Dec 19.
24. Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese. Han X, etal., Med Sci Monit. 2015 Jun 12;21:1707-15. doi: 10.12659/MSM.893471.
25. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
26. IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. He Y, etal., Carcinogenesis. 2009 Nov;30(11):1916-22. doi: 10.1093/carcin/bgp226. Epub 2009 Oct 1.
27. Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins. Jaffray C, etal., J Gastrointest Surg. 2000 Jul-Aug;4(4):370-7; discussion 377-8.
28. A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance. Jeong JH, etal., Mol Cell. 2017 Jan 5;65(1):154-167. doi: 10.1016/j.molcel.2016.11.034. Epub 2016 Dec 29.
29. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
30. Acetaldehyde inhibits NF-kappaB activation through IkappaBalpha preservation in rat Kupffer cells. Jokelainen K, etal., Biochem Biophys Res Commun. 1998 Dec 30;253(3):834-6.
31. Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Kang YM, etal., Cardiovasc Res. 2009 Jun 1;82(3):503-12. doi: 10.1093/cvr/cvp073. Epub 2009 Feb 25.
32. Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition. Kim SJ and Lee SM, Toxicol Appl Pharmacol. 2012 Jan 1;258(1):43-50. doi: 10.1016/j.taap.2011.10.005. Epub 2011 Oct 14.
33. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. Kühnel F, etal., J Biol Chem. 2000 Mar 3;275(9):6421-7. doi: 10.1074/jbc.275.9.6421.
34. Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model. Lee KM, etal., Eur J Pain. 2009 Sep;13(8):794-806. doi: 10.1016/j.ejpain.2008.09.009. Epub 2008 Oct 19.
35. NFKB1 promoter polymorphism: A new predictive marker of cytomegalovirus infection after kidney transplantation. Leone F, etal., Transpl Infect Dis. 2019 Feb;21(1):e13027. doi: 10.1111/tid.13027. Epub 2018 Dec 6.
36. The Association between NFKBIA Polymorphisms and the Progression of Chronic Hepatitis B Virus Infection among the Chinese Han Population. Lin Y, etal., Jpn J Infect Dis. 2018 Jan 23;71(1):21-27. doi: 10.7883/yoken.JJID.2017.161. Epub 2017 Oct 31.
37. Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats. Lonati C, etal., Peptides. 2013 Dec;50:145-52.
38. Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats. Lonati C, etal., Peptides. 2013 Oct 25. pii: S0196-9781(13)00346-X. doi: 10.1016/j.peptides.2013.10.014.
39. Activation of NF-kappaB is a critical element in the antiapoptotic effect of anesthetic preconditioning. Lu X, etal., Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1296-304. doi: 10.1152/ajpheart.01282.2008. Epub 2009 Mar 20.
40. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
41. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IkappaBalpha/NF-kappaB, MAPKs, and mitochondria-dependent pathways: Prophylactic role of arjunolic acid. Manna P, etal., Free Radic Biol Med. 2010 Jun 1;48(11):1465-84. doi: 10.1016/j.freeradbiomed.2010.02.025. Epub 2010 Feb 25.
42. NF¿B signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. McCall P, etal., Br J Cancer. 2012 Oct 23;107(9):1554-63. doi: 10.1038/bjc.2012.372.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells. Michalke M, etal., FEBS Lett. 2000 Jan 7;465(1):64-8.
45. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Moriuchi S, etal., Cancer Gene Ther. 2005 May;12(5):487-96. doi: 10.1038/sj.cgt.7700816.
46. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. Nakajima K, etal., Neurosci Lett. 2006 Jul 3;401(3):199-202. Epub 2006 Mar 31.
47. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
48. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
49. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. Parker KM, etal., Cancer Genet Cytogenet. 2002 Aug;137(1):43-8.
50. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Peng B, etal., Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15193-8. doi: 10.1073/pnas.1005533107. Epub 2010 Aug 9.
51. [Serumimmunological study of moxibustion on helicobacter pylori gastritis in rats]. Peng Y, etal., Zhongguo Zhen Jiu. 2014 Aug;34(8):783-90.
52. Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. Phillips T and Leeuwenburgh C, FASEB J. 2005 Apr;19(6):668-70. Epub 2005 Jan 21.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. Roh GS, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L184-91. Epub 2010 May 14.
60. Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. Ross JS, etal., Clin Cancer Res. 2004 Apr 1;10(7):2466-72.
61. Genetic susceptibility to invasive pneumococcal disease. Sangil A, etal., Infect Genet Evol. 2018 Apr;59:126-131. doi: 10.1016/j.meegid.2018.01.024. Epub 2018 Jan 31.
62. Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappaB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats. Selcuk MY, etal., Nutr Metab (Lond). 2012 Apr 8;9:30. doi: 10.1186/1743-7075-9-30.
63. Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction. Seymour EM, etal., Hypertension. 2010 May;55(5):1179-85. doi: 10.1161/HYPERTENSIONAHA.109.149393. Epub 2010 Mar 15.
64. Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Sheehan M, etal., Mol Pharmacol. 2002 May;61(5):953-63. doi: 10.1124/mol.61.5.953.
65. Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone. Shimada Y, etal., Toxicology. 2010 Feb 9;268(3):213-8. doi: 10.1016/j.tox.2009.12.019. Epub 2010 Jan 5.
66. Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Shukla S, etal., Prostate. 2005 Aug 1;64(3):224-39.
67. A novel NFKBIA variant substituting serine 36 of IκBα causes immunodeficiency with warts, bronchiectasis and juvenile rheumatoid arthritis in the absence of ectodermal dysplasia. Sogkas G, etal., Clin Immunol. 2020 Jan;210:108269. doi: 10.1016/j.clim.2019.108269. Epub 2019 Nov 1.
68. Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma. Spink CF, etal., Cancer Lett. 2007 Feb 8;246(1-2):92-9. Epub 2006 Mar 15.
69. Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Tang Y, etal., Am J Pathol. 2010 Jan;176(1):158-67. doi: 10.2353/ajpath.2010.090548. Epub 2009 Dec 11.
70. [Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic syndrome]. Tao YH, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):230-3.
71. Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii. Tato CM, etal., J Immunol. 2003 Mar 15;170(6):3139-46. doi: 10.4049/jimmunol.170.6.3139.
72. Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats. Teng W, etal., Mediators Inflamm. 2009;2009:473276. doi: 10.1155/2009/473276. Epub 2010 Jan 31.
73. Sequence of rat RL/IF-1 encoding an IkappaB, and comparison with related proteins containing notch-like repeats Tewari M, etal., Nucleic Acids Res 1992 Feb 11;20(3):607.
74. Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma. Thomas RK, etal., Br J Haematol. 2004 Jul;126(1):50-4.
75. Regulation of nuclear factor-kappa B and its inhibitor I kappa B-alpha/MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis. Toossi Z, etal., J Immunol. 1997 Oct 15;159(8):4109-16.
76. Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model. Villar J, etal., Respir Res. 2010 Mar 3;11:27. doi: 10.1186/1465-9921-11-27.
77. Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis. Wang YH, etal., Int Immunopharmacol. 2011 Oct;11(10):1620-7. doi: 10.1016/j.intimp.2011.05.024. Epub 2011 Jun 12.
78. Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Widen C, etal., Biochem J. 2003 Jul 1;373(Pt 1):211-20.
79. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
80. The effects of PDTC plus leflunomide and cyclosporine on the NF-kappaB signaling pathway in mouse-to-rat cardiac xenografts. Yang G, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Apr;29(2):202-6. doi: 10.1007/s11596-009-0213-2. Epub 2009 Apr 28.
81. Hyperbaric oxygen reduces inflammatory response in acute pancreatitis by inhibiting NF-kappaB activation. Yu X, etal., Eur Surg Res. 2009;42(2):130-5. doi: 10.1159/000196164. Epub 2009 Jan 28.
82. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
83. A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats. Yuan MJ, etal., Eur J Pharmacol. 2009 Sep 15;618(1-3):52-7. doi: 10.1016/j.ejphar.2009.07.015. Epub 2009 Jul 17.
84. Polymorphisms in NF-¿B pathway genes & their association with risk of lung cancer in the Chinese population. Zhang JW, etal., Pak J Med Sci. 2015 Nov-Dec;31(6):1411-6. doi: 10.12669/pjms.316.7935.
85. Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma. Zhang Q, etal., Ann Oncol. 2014 Dec;25(12):2413-2419. doi: 10.1093/annonc/mdu451. Epub 2014 Sep 15.
86. ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. Zhao J, etal., Front Immunol. 2019 Nov 5;10:2531. doi: 10.3389/fimmu.2019.02531. eCollection 2019.
87. Protection of carbon monoxide-releasing molecule against lung injury induced by limb ischemia-reperfusion. Zhou JL, etal., Chin J Traumatol. 2009 Apr;12(2):71-6.
88. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. Zingarelli B, etal., J Immunol. 2003 Dec 15;171(12):6827-37. doi: 10.4049/jimmunol.171.12.6827.
Additional References at PubMed
PMID:1493333   PMID:1588976   PMID:3140380   PMID:7679069   PMID:7739562   PMID:8889548   PMID:9859996   PMID:11493922   PMID:11799106   PMID:11931770   PMID:12200125   PMID:12477932  
PMID:12700242   PMID:12872135   PMID:12897149   PMID:14743216   PMID:14764603   PMID:15308505   PMID:15692051   PMID:15777848   PMID:15845452   PMID:15946255   PMID:16081881   PMID:16648481  
PMID:16875840   PMID:16928772   PMID:16938301   PMID:16938483   PMID:16951195   PMID:17878344   PMID:18261938   PMID:18278452   PMID:18505784   PMID:19245366   PMID:20442316   PMID:21737317  
PMID:21874024   PMID:22022389   PMID:22848609   PMID:23262141   PMID:23328071   PMID:23374966   PMID:23418625   PMID:23729669   PMID:24173240   PMID:24349514   PMID:25038658   PMID:25268311  
PMID:25937534   PMID:26101953   PMID:26621632   PMID:27312547   PMID:27693495   PMID:29147465   PMID:31816325   PMID:32007531   PMID:32926510   PMID:37768316  


Genomics

Comparative Map Data
Nfkbia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,593,844 - 78,597,307 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl678,593,847 - 78,597,072 (-)EnsemblGRCr8
mRatBN7.2672,858,713 - 72,861,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx673,278,856 - 73,282,085 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,585,214 - 73,588,443 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,013,851 - 73,017,079 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,267,227 - 76,270,457 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)Ensemblrn6Rnor6.0
Rnor_5.0685,803,990 - 85,807,223 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4675,729,302 - 75,732,475 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera671,699,196 - 71,702,411 (-)NCBICelera
RGSC_v3.1675,732,430 - 75,735,531 (-)NCBI
Cytogenetic Map6q23NCBI
NFKBIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,401,513 - 35,404,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,401,079 - 35,404,749 (-)Ensemblhg38GRCh38
GRCh371435,870,719 - 35,873,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,940,468 - 34,943,695 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341434,940,467 - 34,943,695NCBI
Celera1415,734,587 - 15,737,850 (-)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,984,422 - 15,987,685 (-)NCBIHuRef
CHM1_11435,870,469 - 35,873,713 (-)NCBICHM1_1
T2T-CHM13v2.01429,589,207 - 29,592,460 (-)NCBIT2T-CHM13v2.0
Nfkbia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,536,194 - 55,539,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)Ensemblmm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBIMGSCv36mm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.0NCBI
Nfkbia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,691,534 - 25,697,520 (+)Ensembl
ChiLan1.0NW_00495540925,691,673 - 25,695,151 (+)NCBIChiLan1.0ChiLan1.0
NFKBIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,715,927 - 36,722,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,932,430 - 35,936,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,155,331 - 16,158,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,337,307 - 34,340,225 (-)NCBIPanPan1.1PanPan1.1panPan2
NFKBIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,100,203 - 14,103,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,100,671 - 14,103,433 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha813,896,355 - 13,899,624 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0814,206,293 - 14,209,091 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,206,278 - 14,209,055 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,907,872 - 13,911,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,972,973 - 13,976,235 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,262,614 - 14,265,883 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfkbia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864046,031,901 - 46,035,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,537,008 - 9,541,612 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,537,793 - 9,541,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,507,822 - 64,511,277 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1764,508,119 - 64,510,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,417,685 - 69,420,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q15-q21NCBI
NFKBIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,211,619 - 12,216,185 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,210,281 - 12,214,854 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660531,174,276 - 1,178,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,384,204 - 1,390,205 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248381,384,337 - 1,387,602 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfkbia
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1768,709,578 - 68,712,822 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nfkbia
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:176
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000009894
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
PMC152658P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2672,859,744 - 72,860,592 (+)MAPPERmRatBN7.2
Rnor_6.0676,268,259 - 76,269,106NCBIRnor6.0
Rnor_5.0685,805,022 - 85,805,869UniSTSRnor5.0
RGSC_v3.4675,730,334 - 75,731,181UniSTSRGSC3.4
Celera671,700,228 - 71,701,075UniSTS
Cytogenetic Map6q23UniSTS
NFKBIA  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2672,859,734 - 72,859,906 (+)MAPPERmRatBN7.2
Rnor_6.0676,268,249 - 76,268,420NCBIRnor6.0
Rnor_5.0685,805,012 - 85,805,183UniSTSRnor5.0
RGSC_v3.4675,730,324 - 75,730,495UniSTSRGSC3.4
Celera671,700,218 - 71,700,389UniSTS
Cytogenetic Map6q23UniSTS
RH141551  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8678,594,326 - 78,594,968 (+)Marker Load Pipeline
mRatBN7.2672,859,195 - 72,859,837 (+)MAPPERmRatBN7.2
Rnor_6.0676,267,710 - 76,268,351NCBIRnor6.0
Rnor_5.0685,804,473 - 85,805,114UniSTSRnor5.0
RGSC_v3.4675,729,785 - 75,730,426UniSTSRGSC3.4
Celera671,699,679 - 71,700,320UniSTS
Cytogenetic Map6q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001105720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY547379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF417507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA509173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB316505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB324027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB793714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW395098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009894   ⟹   ENSRNOP00000009894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl678,593,847 - 78,597,072 (-)Ensembl
mRatBN7.2 Ensembl672,858,716 - 72,861,941 (-)Ensembl
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114471   ⟹   ENSRNOP00000090469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)Ensembl
RefSeq Acc Id: NM_001105720   ⟹   NP_001099190
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,593,844 - 78,597,072 (-)NCBI
mRatBN7.2672,858,713 - 72,861,941 (-)NCBI
Rnor_6.0676,267,227 - 76,270,457 (-)NCBI
Rnor_5.0685,803,990 - 85,807,223 (-)NCBI
RGSC_v3.4675,729,302 - 75,732,475 (-)RGD
Celera671,699,196 - 71,702,411 (-)RGD
Sequence:
RefSeq Acc Id: XM_063261563   ⟹   XP_063117633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8678,593,844 - 78,597,307 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099190 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117633 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66886 (Get FASTA)   NCBI Sequence Viewer  
  EDM03427 (Get FASTA)   NCBI Sequence Viewer  
  EDM03428 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009894
  ENSRNOP00000009894.5
GenBank Protein Q63746 (Get FASTA)   NCBI Sequence Viewer  
  QST77142 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099190   ⟸   NM_001105720
- UniProtKB: B2RYS5 (UniProtKB/Swiss-Prot),   Q63746 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009894   ⟸   ENSRNOT00000009894
Ensembl Acc Id: ENSRNOP00000090469   ⟸   ENSRNOT00000114471
RefSeq Acc Id: XP_063117633   ⟸   XM_063261563
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADL6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63746-F1-model_v2 AlphaFold Q63746 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694606
Promoter ID:EPDNEW_R5131
Type:single initiation site
Name:Nfkbia_1
Description:NFKB inhibitor alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0676,270,407 - 76,270,467EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3171 AgrOrtholog
BioCyc Gene G2FUF-37486 BioCyc
Ensembl Genes ENSRNOG00000007390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009894 ENTREZGENE
  ENSRNOT00000009894.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6890357 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  NF-kappa-B_inhibitor UniProtKB/Swiss-Prot
KEGG Report rno:25493 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188827 IMAGE-MGC_LOAD
NCBI Gene 25493 ENTREZGENE
PANTHER NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
  NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  Ank_5 UniProtKB/Swiss-Prot
PhenoGen Nfkbia PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007390 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A8A1UAU6_RAT UniProtKB/TrEMBL
  A0A8I6ADL6 ENTREZGENE
  A6HBM3_RAT UniProtKB/TrEMBL
  B2RYS5 ENTREZGENE
  IKBA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RYS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Nfkbia  NFKB inhibitor alpha  Nfkbia  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Nfkbia  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha  Nfkbia  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Nfkbia  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Nfkbia  Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha      Name withdrawn 67952 WITHDRAWN