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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbia
Name: NFKB inhibitor alpha
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiadecreases expressionISONfkbia (Mus musculus)6480464CTDdeoxynivalenol results in decreased expression of NFKBIA mRNA; deoxynivalenol results in decreased expression of NFKBIA proteinPMID:23253260 PMID:34400200 PMID:8887449
Nfkbiaincreases degradationISONFKBIA (Homo sapiens)6480464CTDdeoxynivalenol results in increased degradation of NFKBIA proteinPMID:18485432
Nfkbiaincreases expressionISONfkbia (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of NFKBIA mRNAPMID:23253260
Nfkbiaincreases phosphorylationISONfkbia (Mus musculus)6480464CTDdeoxynivalenol results in increased phosphorylation of NFKBIA proteinPMID:24937323 PMID:34400200
Nfkbiamultiple interactionsISONfkbia (Mus musculus)6480464CTDdeoxynivalenol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein]PMID:26961612
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTDlipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased degradation of NFKBIA protein]PMID:18485432
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