NFKBIA (NFKB inhibitor alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: NFKBIA (NFKB inhibitor alpha) Sus scrofa
Analyze
Symbol: NFKBIA
Name: NFKB inhibitor alpha
RGD ID: 14085975
Description: ENCODES a protein that exhibits enzyme binding (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); canonical NF-kappaB signal transduction (ortholog); cellular response to cytokine stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; interleukin-23 signaling pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); Adenoviridae Infections (ortholog); alcoholic hepatitis (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); plasma membrane (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; carbon monoxide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ECI-6; ECI-6/IKBA; I-kappa-B-alpha; ikappaBalpha; ikB-alpha; IKBA; NF-kappa-B inhibitor alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,507,822 - 64,511,277 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,508,119 - 64,510,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,417,685 - 69,420,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q15-q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
Adenoviridae Infections  (ISO)
alcoholic hepatitis  (ISO)
arteriosclerosis  (ISO)
atopic dermatitis  (ISO)
brain ischemia  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Fibrosis  (ISO)
Cerebral Hemorrhage  (ISO)
childhood-onset asthma  (ISO)
Chronic Hepatitis B  (ISO)
Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis  (ISO)
COVID-19  (ISO)
cryptorchidism  (ISO)
Cytomegalovirus Infections  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
ectodermal dysplasia and immunodeficiency 2  (ISO)
encephalitis  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
gastritis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
pancreatic cancer  (ISO)
Pneumococcal Infections  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy Complications  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary tuberculosis  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
toxic shock syndrome  (ISO)
toxoplasmosis  (ISO)
Transplant Rejection  (ISO)
vasculitis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to tumor necrosis factor  (IBA,IEA,ISO)
cytoplasmic sequestering of NF-kappaB  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO,ISS)
liver regeneration  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of myeloid cell differentiation  (ISO,ISS)
negative regulation of Notch signaling pathway  (ISO,ISS)
non-canonical NF-kappaB signal transduction  (ISO)
Notch signaling pathway  (ISO)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
protein import into nucleus  (ISO)
regulation of cell population proliferation  (ISO,ISS)
regulation of gene expression  (ISO)
response to ethanol  (ISO)
response to exogenous dsRNA  (ISO,ISS)
response to lipopolysaccharide  (ISO,ISS)
response to muramyl dipeptide  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
toll-like receptor 4 signaling pathway  (IBA,IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA)
nucleus  (IEA,ISS)
plasma membrane  (ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7835710   PMID:8334993   PMID:8661710   PMID:14681463   PMID:15679890   PMID:18632959   PMID:21450812   PMID:22301074   PMID:29115518   PMID:38501350  


Genomics

Comparative Map Data
NFKBIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,507,822 - 64,511,277 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,508,119 - 64,510,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,417,685 - 69,420,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q15-q21NCBI
NFKBIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,401,513 - 35,404,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,401,079 - 35,404,749 (-)EnsemblGRCh38hg38GRCh38
GRCh371435,870,719 - 35,873,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,940,468 - 34,943,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341434,940,467 - 34,943,695NCBI
Celera1415,734,587 - 15,737,850 (-)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,984,422 - 15,987,685 (-)NCBIHuRef
CHM1_11435,870,469 - 35,873,713 (-)NCBICHM1_1
T2T-CHM13v2.01429,589,207 - 29,592,460 (-)NCBIT2T-CHM13v2.0
Nfkbia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,536,194 - 55,539,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)EnsemblGRCm39 Ensembl
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBIMGSCv36mm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.0NCBI
Nfkbia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,593,844 - 78,597,307 (-)NCBIGRCr8
mRatBN7.2672,858,713 - 72,861,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,278,856 - 73,282,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,585,214 - 73,588,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,013,851 - 73,017,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,267,227 - 76,270,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,803,990 - 85,807,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,729,302 - 75,732,475 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,732,430 - 75,735,531 (-)NCBI
Celera671,699,196 - 71,702,411 (-)NCBICelera
Cytogenetic Map6q23NCBI
Nfkbia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,691,534 - 25,697,520 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,691,673 - 25,695,151 (+)NCBIChiLan1.0ChiLan1.0
NFKBIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,715,927 - 36,722,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,932,430 - 35,936,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,155,331 - 16,158,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,337,307 - 34,340,225 (-)NCBIpanpan1.1PanPan1.1panPan2
NFKBIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,100,203 - 14,103,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,100,671 - 14,103,433 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,896,355 - 13,899,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0814,206,293 - 14,209,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,206,278 - 14,209,055 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,907,872 - 13,911,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,972,973 - 13,976,235 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,262,614 - 14,265,883 (-)NCBIUU_Cfam_GSD_1.0
Nfkbia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864046,031,901 - 46,035,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,537,008 - 9,541,612 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,537,793 - 9,541,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,211,619 - 12,216,185 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,210,281 - 12,214,854 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660531,174,276 - 1,178,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,384,204 - 1,390,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,384,337 - 1,387,602 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NFKBIA
64 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 8 2 3 3
Low 15
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A38490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEMK02000056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK239662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK389460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY609599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT797470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN421464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN421467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP326714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01112587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z35483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSSCT00000002184   ⟹   ENSSSCP00000002133
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl764,507,822 - 64,511,277 (+)Ensembl
RefSeq Acc Id: NM_001005150   ⟹   NP_001005150
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1764,508,119 - 64,510,754 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001005150   ⟸   NM_001005150
- UniProtKB: F2Q9A9 (UniProtKB/Swiss-Prot),   Q08353 (UniProtKB/Swiss-Prot),   A0A8D0K6A0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000002133   ⟸   ENSSSCT00000002184


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001952 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005037238 UniProtKB/TrEMBL
  ENSSSCG00015029389 UniProtKB/Swiss-Prot
  ENSSSCG00025067390 UniProtKB/Swiss-Prot
  ENSSSCG00030058851 UniProtKB/Swiss-Prot
  ENSSSCG00035073638 UniProtKB/Swiss-Prot
  ENSSSCG00040041514 UniProtKB/Swiss-Prot
  ENSSSCG00045010107 UniProtKB/Swiss-Prot
  ENSSSCG00050006268 UniProtKB/Swiss-Prot
  ENSSSCG00055029632 UniProtKB/Swiss-Prot
  ENSSSCG00060065186 UniProtKB/Swiss-Prot
  ENSSSCG00065059454 UniProtKB/Swiss-Prot
  ENSSSCG00070007418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002184 ENTREZGENE
  ENSSSCT00000002184.6 UniProtKB/Swiss-Prot
  ENSSSCT00005059642.1 UniProtKB/TrEMBL
  ENSSSCT00015039015.1 UniProtKB/Swiss-Prot
  ENSSSCT00025092560.1 UniProtKB/Swiss-Prot
  ENSSSCT00030082138.1 UniProtKB/Swiss-Prot
  ENSSSCT00035099812.1 UniProtKB/Swiss-Prot
  ENSSSCT00040055590.1 UniProtKB/Swiss-Prot
  ENSSSCT00045017158.1 UniProtKB/Swiss-Prot
  ENSSSCT00050008579.1 UniProtKB/Swiss-Prot
  ENSSSCT00055058871.1 UniProtKB/Swiss-Prot
  ENSSSCT00060088999.1 UniProtKB/Swiss-Prot
  ENSSSCT00065081421.1 UniProtKB/Swiss-Prot
  ENSSSCT00070014285.1 UniProtKB/TrEMBL
  ENSSSCT00070014299.1 UniProtKB/Swiss-Prot
  ENSSSCT00070014305.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:406188 UniProtKB/Swiss-Prot
NCBI Gene NFKBIA ENTREZGENE
PANTHER NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
  NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
  NF-KAPPA-B INHIBITOR ALPHA UniProtKB/TrEMBL
  NF-KAPPA-B INHIBITOR ALPHA UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T9P3_PIG UniProtKB/TrEMBL
  A0A8D0K6A0 ENTREZGENE, UniProtKB/TrEMBL
  F2Q9A6_PIG UniProtKB/TrEMBL
  F2Q9A9 ENTREZGENE
  IKBA_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F2Q9A9 UniProtKB/Swiss-Prot
VGNC ID VGNC:90721 ENTREZGENE