Il5 (interleukin 5) - Rat Genome Database

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Gene: Il5 (interleukin 5) Rattus norvegicus
Analyze
Symbol: Il5
Name: interleukin 5
RGD ID: 2900
Description: Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma and stomach cancer. Orthologous to human IL5 (interleukin 5); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-4 signaling pathway; interleukin-5 signaling pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-cell growth factor II; BCGF-II; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor; IL-5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; T-cell replacing factor; TRF
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,375,132 - 38,378,003 (+)EnsemblGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)Ensemblrn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,4-dithiothreitol  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-nitro-m-cresol  (ISO)
5-azacytidine  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
acetic acid  (ISO)
acetone  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-galactosylceramide  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
asbestos  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
Azoxymethane  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betamethasone valerate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
budesonide  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcipotriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (ISO)
cetirizine  (ISO)
chloroform  (ISO)
cilostazol  (ISO)
clobenpropit  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
deoxynivalenol  (ISO)
desloratadine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dioscin  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
emamectin benzoate  (ISO)
emodin  (ISO)
epinastine  (ISO)
Erionite  (ISO)
ethene  (EXP)
fenvalerate  (EXP)
ferric oxide  (ISO)
fisetin  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fluorescein 5-isothiocyanate  (ISO)
flutamide  (ISO)
fluticasone  (ISO)
formaldehyde  (EXP,ISO)
fragrance  (ISO)
furfuryl alcohol  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
glyburide  (ISO)
glyphosate  (ISO)
gossypin  (EXP)
GSK2193874  (ISO)
hexachlorobenzene  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP)
hydroxysafflor yellow A  (ISO)
hydroxytyrosol  (ISO)
IC-87114  (ISO)
ICI 118551  (ISO)
ionomycin  (EXP,ISO)
isosilybin A  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
luteolin  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP,ISO)
methoxychlor  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
Monocyte locomotion inhibitory factor  (ISO)
montelukast  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naproxen  (EXP)
nicardipine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitroprusside  (EXP)
nitrososulfamethoxazole  (ISO)
Nivalenol  (ISO)
Nonylphenol  (ISO)
o-anisidine  (ISO)
ozone  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
prostaglandin E2  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
ribavirin  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
Silidianin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
solasodine  (EXP)
SR 144528  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sulfamethoxazole  (ISO)
sumatriptan  (EXP)
superoxide  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloromethane  (EXP,ISO)
thiazoles  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tolnaftate  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
verrucarin A  (ISO)
vitamin E  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Andemariam B, etal., Transl Res. 2015 Sep;166(3):254-68. doi: 10.1016/j.trsl.2015.03.001. Epub 2015 Mar 16.
2. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
3. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
4. Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Chiba Y, etal., Immunol Lett. 2005 Feb 15;97(1):123-9.
5. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Cho SH, etal., Am J Respir Crit Care Med. 2005 Feb 1;171(3):224-30. Epub 2004 Oct 22.
6. A profile of immune response to herpesvirus is associated with radiographic damage in rheumatoid arthritis. Davis JM 3rd, etal., Arthritis Res Ther. 2012 Jan 31;14(1):R24.
7. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. Desreumaux P, etal., Gastroenterology. 1996 Mar;110(3):768-74.
8. Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. Elomaa AP, etal., BMC Psychiatry. 2012 Jan 9;12:2.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2008 Jul;28(4):298-305. Epub 2007 Jun 28.
10. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Engel MA, etal., Dig Liver Dis. 2012 Jan;44(1):24-9. Epub 2011 Oct 22.
11. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Fedenko ES, etal., Self Nonself. 2011 Apr;2(2):120-124. Epub 2011 Apr 1.
12. Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease. Freidin MB, etal., Comp Funct Genomics. 2003;4(3):346-50.
13. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. Fuss IJ, etal., J Immunol. 1996 Aug 1;157(3):1261-70.
14. Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. Gibson PG, etal., J Allergy Clin Immunol. 1998 Mar;101(3):320-6.
15. Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. Glaab T, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L565-73.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification. Haddad el-B, etal., J Immunol 2002 Mar 15;168(6):3004-16.
18. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness. Hall LR, etal., Infect Immun. 1998 Sep;66(9):4425-30.
19. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Hamelmann E, etal., Am J Respir Crit Care Med. 1999 Sep;160(3):934-41.
20. Cloning and expression of interleukin-5 from rats. He XY, etal., Transplant Proc. 1999 May;31(3):1574-6.
21. IL-5 prolongs allograft survival by downregulating IL-2 and IFN-gamma cytokines. He XY, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):703-4.
22. Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors. Inagaki A, etal., Int J Cancer. 2006 Jun 15;118(12):3054-61.
23. Generation of rat eosinophils by recombinant rat interleukin-5 in vitro and in vivo. Ishihara K, etal., Biochim Biophys Acta. 2000 Apr 15;1501(1):25-32.
24. Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival. Ishihara K, etal., Biochim Biophys Acta. 2001 Apr 30;1536(1):73-84.
25. Analysis of biological activities of recombinant rat interleukin-5. Ishihara K, etal., Int Arch Allergy Immunol. 1999;120 Suppl 1:11-4.
26. Analysis of the prolongation of rat eosinophil survival induced by recombinant rat interleukin-5. Ishihara K, etal., Int Arch Allergy Immunol. 2000 May;122 Suppl 1:36-9.
27. Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
28. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. Johnson TR, etal., J Leukoc Biol. 2008 Sep;84(3):748-59. Epub 2008 Jun 2.
29. Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Joshi AD, etal., Am J Respir Crit Care Med. 2009 Apr 15;179(8):705-16. Epub 2009 Jan 16.
30. Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model. Kim SW, etal., Allergy. 2013 Jul;68(7):862-9. doi: 10.1111/all.12132. Epub 2013 Jun 10.
31. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
32. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. Lee JJ, etal., J Exp Med. 1997 Jun 16;185(12):2143-56.
33. Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma. Lee MY, etal., Int Immunopharmacol. 2012 Jan;12(1):117-24. Epub 2011 Nov 12.
34. [Serum levels of IL-5 and LTB4 in children with Henoch-Schonlein purpura]. Liao PY and Wu SH, Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):198-200.
35. [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models] Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Aug;29(8):558-62.
36. [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]. Liu D, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jul;16(7):759-63.
37. Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Mahajan R, etal., Jpn J Clin Oncol. 2008 Sep;38(9):626-33. doi: 10.1093/jjco/hyn075. Epub 2008 Aug 7.
38. Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. Marra SM, etal., Am J Rhinol Allergy. 2011 Sep-Oct;25(5):e196-9.
39. T-cell activation genes differentially expressed at birth in CD4(+) T-cells from children who develop IgE food allergy. Martino DJ, etal., Allergy. 2012 Feb;67(2):191-200. doi: 10.1111/j.1398-9995.2011.02737.x. Epub 2011 Nov 11.
40. Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis. Masterson JC, etal., Gut. 2014 Jan;63(1):43-53. doi: 10.1136/gutjnl-2012-303631. Epub 2012 Nov 17.
41. Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment. Medhat A, etal., J Infect Dis. 1998 Aug;178(2):512-9.
42. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
43. Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior. Mourglia-Ettlin G, etal., PLoS Negl Trop Dis. 2011 Aug;5(8):e1293. doi: 10.1371/journal.pntd.0001293. Epub 2011 Aug 30.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Increased vascular endothelial growth factor in acute eosinophilic pneumonia. Nishigaki Y, etal., Eur Respir J. 2003 May;21(5):774-8.
46. [An investigation of the clinical utility of serum interleukin-5 measurements in bronchial asthma patients]. Onizuka R, etal., Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1215-22.
47. Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5. Ovington KS, etal., Immunology. 1998 Nov;95(3):488-93.
48. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Pan HF, etal., Mol Biol Rep. 2013 Jan;40(1):391-9. doi: 10.1007/s11033-012-2073-2. Epub 2012 Oct 9.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
52. GOA pipeline RGD automated data pipeline
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
55. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. Ruscher K, etal., PLoS One. 2012;7(9):e45118. doi: 10.1371/journal.pone.0045118. Epub 2012 Sep 18.
56. Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Saito H, etal., J Immunol. 2002 Mar 15;168(6):3017-23.
57. Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Sasaki O, etal., Parasite Immunol. 1993 Jun;15(6):349-54.
58. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Stoner GD, etal., Pharm Res. 2010 Jun;27(6):1138-45. Epub 2010 Mar 16.
59. Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury. Su Y, etal., Neuroscience. 2014 Apr 25;266:56-65. doi: 10.1016/j.neuroscience.2014.02.006. Epub 2014 Feb 14.
60. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease. Su YC, etal., J Virol. 2015 Feb;89(3):1564-78. doi: 10.1128/JVI.01536-14. Epub 2014 Nov 19.
61. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
62. Preventive effect of hochu-ekki-to, a Japanese herbal medicine, on bleomycin-induced lung injury in mice. Tajima S, etal., Respirology. 2007 Nov;12(6):814-22.
63. Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response. Tajiri N, etal., Brain Res. 2014 Apr 22;1559:65-71. doi: 10.1016/j.brainres.2014.02.041. Epub 2014 Mar 3.
64. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Tanaka H, etal., Am J Respir Cell Mol Biol. 2004 Jul;31(1):62-8. Epub 2004 Feb 19.
65. TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas. Thielen C, etal., Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.
66. CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. Tillie-Leblond I, etal., Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):586-92.
67. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. Tominaga A, etal., J Exp Med. 1991 Feb 1;173(2):429-37.
68. IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity. Tran GT, etal., Blood. 2012 May 10;119(19):4441-50. doi: 10.1182/blood-2011-12-396101. Epub 2012 Feb 6.
69. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
70. Expression of leukotriene biosynthetic enzymes in tonsillar tissue of children with obstructive sleep apnea: a prospective nonrandomized study. Tsaoussoglou M, etal., JAMA Otolaryngol Head Neck Surg. 2014 Oct;140(10):944-50. doi: 10.1001/jamaoto.2014.1936.
71. The rat interleukin-5 gene: characterization and expression by retroviral gene transfer and polymerase chain reaction. Uberla K, etal., Cytokine 1991 Jan;3(1):72-81.
72. Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. Ustun S, etal., World J Gastroenterol. 2004 Dec 15;10(24):3643-6.
73. Human knee synovial fluid cytokines correlated with grade of knee osteoarthritis--a pilot study. Vangsness CT Jr, etal., Bull NYU Hosp Jt Dis. 2011;69(2):122-7.
74. Knockdown of neurokinin-1 receptor expression by small interfering RNA prevents the development of allergic rhinitis in rats. Wang H, etal., Inflamm Res. 2013 Oct;62(10):903-10. doi: 10.1007/s00011-013-0649-5. Epub 2013 Aug 11.
75. Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Wen X, etal., Eur J Immunol. 2004 Oct;34(10):2740-9.
76. In vivo changes of hemopoietic progenitors and the expression of the interleukin 5 gene in eosinophilic mice infected with Toxocara canis. Yamaguchi Y, etal., Exp Hematol. 1990 Dec;18(11):1152-7.
77. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. Yamamoto N, etal., J Dermatol Sci. 2003 Nov;33(2):121-6.
78. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Yan XJ, etal., Blood. 2011 Nov 10;118(19):5201-10. doi: 10.1182/blood-2011-03-342436. Epub 2011 Sep 12.
79. The clinical characteristics of steroid responsive nephrotic syndrome of children according to the serum immunoglobulin E levels and cytokines. Youn YS, etal., Yonsei Med J. 2012 Jul 1;53(4):715-22. doi: 10.3349/ymj.2012.53.4.715.
80. Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic rats. Zeng D, etal., Respirology. 2010 Jan;15(1):132-40. Epub 2009 Nov 30.
Additional References at PubMed
PMID:7749983   PMID:10872802   PMID:11057672   PMID:15087456   PMID:15220135   PMID:15240714   PMID:16275384   PMID:16769892   PMID:18268038   PMID:18510219   PMID:18997793   PMID:20041150  
PMID:21460847   PMID:28132394   PMID:28652007  


Genomics

Comparative Map Data
Il5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,375,132 - 38,378,003 (+)EnsemblGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)Ensemblrn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
IL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)Ensemblhg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
Il5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)Ensemblmm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
Il5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,937,894 - 3,939,358 (-)Ensembl
ChiLan1.0NW_0049554083,937,128 - 3,951,784 (-)NCBIChiLan1.0ChiLan1.0
IL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,852,984 - 127,868,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,985,380 - 126,007,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,955,377 - 127,961,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,119,608 - 134,121,682 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,119,608 - 134,121,675 (-)EnsemblpanPan2panpan1.1
IL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,832,147 - 134,835,212 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,832,143 - 134,846,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,301,702 - 140,315,329 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,360,143 - 35,375,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,360,506 - 35,362,178 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,568,292 - 42,583,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,556,797 - 39,559,119 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473339,544,487 - 39,558,943 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Il5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1936,201,293 - 36,204,023 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il5
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000010729
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
sensory system
visual system
3 2 13 9 19 6 2 12 9 11 10 19 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000010729   ⟹   ENSRNOP00000010729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1038,375,132 - 38,378,003 (+)Ensembl
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)Ensembl
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)Ensembl
RefSeq Acc Id: NM_021834   ⟹   NP_068606
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,375,132 - 38,378,003 (+)NCBI
mRatBN7.21037,874,342 - 37,877,213 (+)NCBI
Rnor_6.01039,066,716 - 39,069,587 (+)NCBI
Rnor_5.01038,848,654 - 38,851,525 (+)NCBI
RGSC_v3.41039,177,786 - 39,180,657 (+)RGD
Celera1037,217,913 - 37,220,782 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_068606 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA09587 (Get FASTA)   NCBI Sequence Viewer  
  EDM04396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010729
  ENSRNOP00000010729.4
GenBank Protein Q08125 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068606   ⟸   NM_021834
- Peptide Label: precursor
- UniProtKB: Q08125 (UniProtKB/Swiss-Prot),   Q9R2C9 (UniProtKB/TrEMBL),   A6HEE1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010729   ⟸   ENSRNOT00000010729

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08125-F1-model_v2 AlphaFold Q08125 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2900 AgrOrtholog
BioCyc Gene G2FUF-25133 BioCyc
Ensembl Genes ENSRNOG00000008111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010729 ENTREZGENE
  ENSRNOT00000010729.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-5 UniProtKB/Swiss-Prot
NCBI Gene 24497 ENTREZGENE
PANTHER INTERLEUKIN-5 UniProtKB/Swiss-Prot
  INTERLEUKIN-5 UniProtKB/Swiss-Prot
Pfam IL5 UniProtKB/Swiss-Prot
PhenoGen Il5 PhenoGen
PRINTS INTERLEUKIN5 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008111 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6HEE1 ENTREZGENE, UniProtKB/TrEMBL
  IL5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R2C9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il5  Interleukin 5 (colony-stimulating factor, eosinophil)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 92% homologous at the amino acid level to mouse Il5 728921
gene_regulation inflammatory response causes increase of mRNA in eosinophils 625643