Gene:	Il5 ( Rattus norvegicus ) interleukin 5
Description:	cytokine with B-cell growth factor activity
Synonyms:	Interleukin 5 (colony-stimulating factor eosinophil);
ArrayIDs:	6688332; X54419cds_at; A_43_P16188; 6350393; GE21519; 1371178_at; 5955942; 5744459; 6352129; 5931803; 5721449;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau7 - Experimental allergic uveoretinitis QTL 7
primer pair:	634997
Homologs
Homo sapiens: IL5     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Il5     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Il5 Rat Celera Assembly 10 37217913 - 37220782     RH 3.4 10 405.8     RGSC genome assembly v3.4 10 39177786 - 39180657     Cytogenetic 10 q22     genome assembly 3.1 10 39187032 - 39189904 Mus musculus Il5 Mouse genome assembly build 36.1 11 53534296 - 53538605     Cytogenetic 11 11 A5/B1 Homo sapiens IL5 human genome assembly 5 131905034 - 131907113     Human genome assembly build 36.2 5 131905035 - 131907113     Cytogenetic 5 q31.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology growth factor activity,  interleukin-5 receptor binding,  cytokine activity (details...)
Biological Process	Gene Ontology positive regulation of B cell proliferation,  positive regulation of transcription factor activity,  immune response ...  (details...)
Cellular Component	Gene Ontology extracellular space,  extracellular region,  soluble fraction (details...)
Disease	Ontology Eosinophilia (details...)
Regulation	Note Reference inflammatory response causes increase of mRNA in eosinophils 625643
Homology	Note Reference 92% homologous at the amino acid level to mouse Il5 728921
External Links
Databases	DATABASE ID SOURCE ProDom: Interleukin_5 IPI UNIPARC: UPI000012D4D3 IPI KEGG Report: rno:24497 ENTREZGENE HomoloGene Group ID: 679 ENTREZGENE Germonline: 2900 Pfam: IL5 IPI KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 05330 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04640 ENTREZGENE KEGG Pathway: 04060 ENTREZGENE KEGG Pathway: 05320 ENTREZGENE KEGG Pathway: 05310 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE InterPro: 4_helix_cytokine-like_core. IPI InterPro: 4_helix_cytokine_core. IPI InterPro: Interleukin_5. IPI IPI: IPI00197557 IPI Ensembl Protein: ENSRNOP00000010729 IPI Gene3D-CATH: 4_helix_cytokine_core IPI Entrez Gene: Il5 ENTREZGENE UniProt: Q9R2C9_RAT IPI UniProt: IL5_RAT IPI Ensembl Genes: ENSRNOG00000008111 IPI RatMap: 34106 ENTREZGENE Superfamily-SCOP: 4_helix_cytokine IPI PANTHER: Interleukin_5 IPI PRINTS: INTERLEUKIN5. IPI
Sequences	Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: X54419 Get FASTA Search GEO Profiles Nucleotide: NM_021834 Get FASTA Search GEO Profiles Nucleotide: AJ011299 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_068606 Get FASTA Protein: CAA09587 Get FASTA Protein: Q08125 Get FASTA Protein: Q9R2C9 Get FASTA Protein: CAA38283 Get FASTA Protein: EDM04396 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 44227
References
Curated References	11 references in RGD related to Il5
Other References	8 other references at PubMed related to Il5
Database Information
RGD ID	2900
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Il5 Interleukin 5 (colony-stimulating factor, eosinophil) APPROVED Symbol and Name status set to approved 70586