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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2900 Species: Rattus norvegicus RGD Object: Gene Symbol: Il5 Name: interleukin 5

Acc ID: CHEBI:53001 Term: nickel sulfate Definition: A metal sulfate compound having nickel(2+) as the counterion. CasRN: 7786-81-4 Chemical ID: MESH:C029938

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:730927	6480464	CTD	Diclofenac inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] Cyclosporine inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein] Hydrocortisone inhibits the reaction [nickel sulfate results in increased secretion of IL5 protein]	PMID:15663561
increases secretion	ISO	RGD:730927	6480464	CTD	nickel sulfate results in increased secretion of IL5 protein	PMID:19572476 PMID:15663561 PMID:15347381 PMID:15270870
increases secretion	ISO	RGD:730927	6480464	CTD	nickel sulfate results in increased secretion of IL5 protein	PMID:10929769 PMID:19572476 PMID:15347381 PMID:15663561 PMID:15270870
increases secretion	ISO	RGD:730927	6480464	CTD	nickel sulfate results in increased secretion of IL5 protein	PMID:10929769 PMID:15270870 PMID:15347381 PMID:15663561 PMID:19572476