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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2900
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:64177
Term: clobenpropit
Definition: An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM.
Chemical ID: MESH:C086108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5affects expressionISOIL5 (Homo sapiens)6480464CTDclobenpropit affects the expression of IL5 proteinPMID:17346280
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