RGD Reference Report - Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma. - Rat Genome Database

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Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma.

Authors: Lee, MY  Ahn, KS  Lim, HS  Yuk, JE  Kwon, OK  Lee, KY  Lee, HK  Oh, SR 
Citation: Lee MY, etal., Int Immunopharmacol. 2012 Jan;12(1):117-24. Epub 2011 Nov 12.
RGD ID: 5687144
Pubmed: PMID:22085848   (View Abstract at PubMed)
DOI: DOI:10.1016/j.intimp.2011.10.021   (Journal Full-text)

Asthma is a persistent inflammatory disease characterized by airway obstruction and hyperresponsiveness in association with airway inflammation. In the current research, we studied the anti-inflammatory and anti-asthmatic effects of tiarellic acid (TA) isolated from Tiarella polyphylla, based on asthmatic parameters, such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness (AHR), reactive oxygen species (ROS) and mucus hypersecretion, in an ovalbumin (OVA)-sensitized/challenged mouse model. TA significantly inhibited increases in IgE, levels of ROS and T helper cytokines, such as interleukin (IL)-4, IL-5, TNF-alpha, and IL-13, in bronchoalveolar lavage fluid (BALF), and effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion in the asthmatic mouse model. In addition, we found that administration of TA attenuated ovalbumin-induced increases in NF-kappaB activity in lungs. The efficacy of TA was comparable to that of montelukast, a currently available anti-asthmatic drug. Our results support the utility of TA as a herbal medicine for asthma treatment and may have application in the development of anti-inflammatory and anti-asthmatic drugs.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
asthma  ISOIl5 (Mus musculus)5687144; 5687144protein:increased expression:lungs and respiratory system fluid/secretionRGD 
asthma  IEP 5687144protein:increased expression:lungs and respiratory system fluid/secretionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il5  (interleukin 5)

Genes (Mus musculus)
Il5  (interleukin 5)

Genes (Homo sapiens)
IL5  (interleukin 5)


Additional Information