RGD Reference Report - [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. - Rat Genome Database

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[Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats].

Authors: Cheng, L  Wang, Z  Jiang, C  Zhang, S 
Citation: Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
RGD ID: 11522769
Pubmed: PMID:24620662   (View Abstract at PubMed)

OBJECTIVE: To observe changes of serum Th1/Th2 cytokines and IgE of rats with experimental allergic rhinitis (AR) treating with Scoparone (20 ml/kg, the concentration is 168 mg/L). METHOD: Forty male SD rats were randomly divided into 4 groups : group NC, group AR, group Sco, group Dxm. The rats were sensitized with OVA and were then treated with Scoparone, during the treatment, the behaviors were observed and the change in nasal mucosa were recorded. The level of serum cytokines IFN-gamma, IL-4, IL-5 and IgE were determined by ELISA. RESULTS: The behavior scores of group Sco were significantly lower than those of group AR, the difference was statistically significant (P < 0.01). Comparing to group Dxm and group NC respectively, the difference was not statistically significant (P > 0.05). The nasal inflammation of group Sco was significantly less than that of group AR. The level of serum IFN-gamma of group Sco was significantly higher than that of group AR, while the levels of serum IgE, IL4, IL-5 of group Sco were significantly lower (P < 0.01). There were no significantly difference between group Sco and group NC, group Dxm, the difference was not statistically significant (P > 0.05). CONCLUSION: Scoparone is highly effective in treating allergic rhinitis by regulating the expression of Th1/Th2 cytokines and IgE.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
allergic rhinitis treatmentISOIl4 (Rattus norvegicus)11522769; 11522769 RGD 
allergic rhinitis treatmentISOIl5 (Rattus norvegicus)11522769; 11522769 RGD 
allergic rhinitis treatmentIEP 11522769; 11522769 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il4  (interleukin 4)
Il5  (interleukin 5)

Genes (Mus musculus)
Il4  (interleukin 4)
Il5  (interleukin 5)

Genes (Homo sapiens)
IL4  (interleukin 4)
IL5  (interleukin 5)


Additional Information