RGD Reference Report - The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. - Rat Genome Database

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The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease.

Authors: Tsai, JJ  Liao, EC  Hsu, JY  Lee, WJ  Lai, YK 
Citation: Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
RGD ID: 4890939
Pubmed: PMID:20858153   (View Abstract at PubMed)
DOI: DOI:10.1080/02770903.2010.491145   (Journal Full-text)

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common disease in the elderly population and is characterized by airway inflammation. Whether it is a progressive condition resulting from allergic inflammation or a distinct condition involving a pathogen-induced reaction remains unclear. OBJECTIVES: To determine the role of allergic inflammation in the pathogenesis of elderly COPD. METHODS: A total of 63 elderly adults (21 mite-allergic COPD patients, 29 non-allergic COPD patients, and 13 normal controls) were recruited in this study. The serum-specific IgE for mites, level of interleukin-5 (IL-5), IL-8, leptin, adiponectin, regulated upon activation normal T cell expressed and secreted (RANTES), growth-related oncogene-alpha (GRO-alpha), vitamin E, and glutathione (GSH) were determined. RESULTS: The serum levels of GRO-alpha in patients with COPD were higher in comparison to normal controls (105.8 +/- 32.7 vs. 7.5 +/- 7.5 pg/mL, p= .021). Compared to patients with non-allergic COPD, patients with mite allergies had a higher serum level of IL-8 (63.2 +/- 12.6 vs. 35.0 +/- 8.2 pg/mL, p= .022). Although both IL-5 and RANTES levels were increased in COPD patients, there were no significant differences between allergic and non-allergic COPD. There were also no differences in serum levels of leptin, adiponectin, vitamin E, and GSH between COPD patients and normal controls. CONCLUSIONS: The increased serum levels of GRO-alpha indicate that it may have potential as a candidate biomarker for elderly COPD patients. There was no difference of eosinophils-related chemokines in allergic and non-allergic COPD. These results indicated that both adipokines and eosinophil-related chemokines only play trivial roles in the pathogenesis of COPD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic obstructive pulmonary disease  IEP 4890939; 4890939protein:increased expression:serumRGD 
chronic obstructive pulmonary disease  ISOCXCL1 (Homo sapiens)4890939; 4890939protein:increased expression:serumRGD 
chronic obstructive pulmonary disease  ISOIL5 (Homo sapiens)4890939; 4890939protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl1  (C-X-C motif chemokine ligand 1)
Il5  (interleukin 5)

Genes (Mus musculus)
Cxcl1  (C-X-C motif chemokine ligand 1)
Il5  (interleukin 5)

Genes (Homo sapiens)
CXCL1  (C-X-C motif chemokine ligand 1)
IL5  (interleukin 5)


Additional Information