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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2900
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:94366
Term: 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one
Definition: A piperazine that has formula C35H38Cl2N8O4.
Chemical ID: MESH:D017964
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5decreases expressionISOIL5 (Homo sapiens)6480464CTDItraconazole results in decreased expression of IL5 mRNAPMID:11886533 PMID:15284827
Il5decreases secretionISOIL5 (Homo sapiens)6480464CTDItraconazole results in decreased secretion of IL5 proteinPMID:11886533 PMID:15284827
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]PMID:11886533
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