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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2900
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il5
Name: interleukin 5
Acc ID: CHEBI:50730
Term: montelukast
Definition: An aliphatic sulfide that has formula 586.18398.
Chemical ID: MESH:C093875
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il5decreases expressionISOIL5 (Homo sapiens)6480464CTDmontelukast results in decreased expression of IL5 mRNAPMID:14619337
Il5multiple interactionsISOIl5 (Mus musculus)6480464CTDmontelukast inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]PMID:30696844
Il5multiple interactionsISOIL5 (Homo sapiens)6480464CTD[montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein; [montelukast co-treated with desloratadine] results in decreased expression of IL5 proteinPMID:15061398
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